Apport des études médico-économiques pour l'accès au marché français d'une nouvelle molécule (l'exemple d'un bisphosphonate dans la maladie osseuse de Paget)

LYON1-BU Santé (693882101) / SudocSudocFranceF

Intérêt de la modélisation dans le suivi pronostique et la mesure de l'impact économique d'une maladie létale (exemple de la leucémie myeloïde chronique)

La question qui se pose avec l'introduction d'un nouvel anti-cancéreux tel que l'imatinib est de connaître l'évolution du nombre de patients traités au cours du temps.Les malades sous imatinib passeront plus tardivement dans des phases plus sévères et survivront plus longtemps. A côté, des bénéfices cliniques apportés à un patient donné, il y aura également un impact en santé publique et sur le budget de la santé, non seulement du fait du transfert de prescriptions, mais aussi du fait de l'augmentation de la prévalence de la maladie. En préambule à la mise sur le marché, les experts en santé publique ont souhaité disposer d'un outil permettant de prédire et comparer l'évolution clinique à 5 ans des malades leucémiques. Ce modèle mathématique quantifie le nombre de malades qui chaque année sera traitée par imatinib et en évalue l'impact budgétaire en comparaison des stratégies thérapeutiques existantes. A la lumière de cette démarche, nous avons discuté les intérêts et les limites de la modélisation en santéThe introduction of a new anti-cancer therapy such as imatinib raises the question of the evolution of the number of patients treated over time. Imatinib retards progression to advanced stages and treared patients will survive longer. Apart from the clinical benefit for individual patients, there is also an impact on public health and on health expenditure, due not only to prescription changes but also through the increased prevalence of the disease. Prior to market access, the manufacter wanted to dispose of a model that could predict and compare the clinical evolution at 5 years of patients with CML. This mathematical model quantifies the number of patients who will be treated each year with imatinib and evaluates the budget impact relative to existing therapeutic strategies. This approach is used as a basis for the analysis and discussion of the interest and limits of modelling in public healthLYON1-BU.Sciences (692662101) / SudocSudocFranceF

Transverse momentum and pseudorapidity distributions of charged hadrons in pp collisions at (s)\sqrt(s) = 0.9 and 2.36 TeV

Measurements of inclusive charged-hadron transverse-momentum and pseudorapidity distributions are presented for proton-proton collisions at sqrt(s) = 0.9 and 2.36 TeV. The data were collected with the CMS detector during the LHC commissioning in December 2009. For non-single-diffractive interactions, the average charged-hadron transverse momentum is measured to be 0.46 +/- 0.01 (stat.) +/- 0.01 (syst.) GeV/c at 0.9 TeV and 0.50 +/- 0.01 (stat.) +/- 0.01 (syst.) GeV/c at 2.36 TeV, for pseudorapidities between -2.4 and +2.4. At these energies, the measured pseudorapidity densities in the central region, dN(charged)/d(eta) for |eta| < 0.5, are 3.48 +/- 0.02 (stat.) +/- 0.13 (syst.) and 4.47 +/- 0.04 (stat.) +/- 0.16 (syst.), respectively. The results at 0.9 TeV are in agreement with previous measurements and confirm the expectation of near equal hadron production in p-pbar and pp collisions. The results at 2.36 TeV represent the highest-energy measurements at a particle collider to date

Measurement of the charge ratio of atmospheric muons with the CMS detector

We present a measurement of the ratio of positive to negative muon fluxes from cosmic ray interactions in the atmosphere, using data collected by the CMS detector both at ground level and in the underground experimental cavern at the CERN LHC. Muons were detected in the momentum range from 5 GeV/ c to 1 TeV/ c . The surface flux ratio is measured to be 1.2766±0.0032(stat.)±0.0032(syst.) , independent of the muon momentum, below 100 GeV/ c . This is the most precise measurement to date. At higher momenta the data are consistent with an increase of the charge ratio, in agreement with cosmic ray shower models and compatible with previous measurements by deep-underground experiments.We present a measurement of the ratio of positive to negative muon fluxes from cosmic ray interactions in the atmosphere, using data collected by the CMS detector both at ground level and in the underground experimental cavern at the CERN LHC. Muons were detected in the momentum range from 5 GeV/c to 1 TeV/c. The surface flux ratio is measured to be 1.2766 \pm 0.0032(stat.) \pm 0.0032 (syst.), independent of the muon momentum, below 100 GeV/c. This is the most precise measurement to date. At higher momenta the data are consistent with an increase of the charge ratio, in agreement with cosmic ray shower models and compatible with previous measurements by deep-underground experiments

Transverse-momentum and pseudorapidity distributions of charged hadrons in pppp collisions at s\sqrt{s} = 7 TeV

Charged-hadron transverse-momentum and pseudorapidity distributions in proton-proton collisions at $\sqrt{s} = 7$~TeV are measured with the inner tracking system of the CMS detector at the LHC. The charged-hadron yield is obtained by counting the number of reconstructed hits, hit-pairs, and fully reconstructed charged-particle tracks. The combination of the three methods gives a charged-particle multiplicity per unit of pseudorapidity \dnchdeta|_{|\eta| < 0.5} = 5.78\pm 0.01\stat\pm 0.23\syst for non-single-diffractive events, higher than predicted by commonly used models. The relative increase in charged-particle multiplicity from $\sqrt{s} = 0.9$ to 7~TeV is 66.1\%\pm 1.0\%\stat\pm 4.2\%\syst. The mean transverse momentum is measured to be 0.545\pm 0.005\stat\pm 0.015\syst\GeVc. The results are compared with similar measurements at lower energies.Charged-hadron transverse-momentum and pseudorapidity distributions in proton-proton collisions at sqrt(s) = 7 TeV are measured with the inner tracking system of the CMS detector at the LHC. The charged-hadron yield is obtained by counting the number of reconstructed hits, hit-pairs, and fully reconstructed charged-particle tracks. The combination of the three methods gives a charged-particle multiplicity per unit of pseudorapidity, dN(charged)/d(eta), for |eta| < 0.5, of 5.78 +/- 0.01 (stat) +/- 0.23 (syst) for non-single-diffractive events, higher than predicted by commonly used models. The relative increase in charged-particle multiplicity from sqrt(s) = 0.9 to 7 TeV is 66.1% +/- 1.0% (stat) +/- 4.2% (syst). The mean transverse momentum is measured to be 0.545 +/- 0.005 (stat) +/- 0.015 (syst) GeV/c. The results are compared with similar measurements at lower energies