Angiotensin type-2 (AT-2)-receptor activation reduces renal fibrosis in cyclosporine nephropathy: evidence for blood-pressure independent effect

Compound 21 (C21), selective agonist of AT2 receptors, shows antinflammatory effects in hypertension and nephroprotection in diabetes. The aim of this study was to evaluate the effects of C21 in cyclosporine nephropathy, which is characterized mainly by tubulo-interstitial fibrosis. Ten days before and during the experimental periods, low-salt diet was administered to Sprague Dawley rats. Cyclosporine-A (15mg/kg/day, i.p.) and cyclosporine-A plus C21 (0.3 mg/kg /day, i.p) were administered for 1 and 4 weeks. Control groups was left without any treatment. Blood pressure (plethysmographic method) and 24 hour albuminuria were measured once a week. At the end of the experiments, the kidneys were excised for histomorphometric analysis of renal fibrosis and for immunohistochemical evaluation of inflammatory infiltrates and type I and IV collagen expression.After 1 and 4 weeks, the rats treated with cyclosporine showed a significant increase (p <0.01) in blood pressure, no significant changes in albuminuria, a significant increase (p <0.01) in glomerular and tubulo-interstitial fibrosis and inflammatory infiltrates as compared to the control rats. Treatment with C21 did not modify the cyclosporine dependent increase of blood pressure, which was higher than in control rats, but after 4 weeks of treatment significantly reduced (p <0.01) glomerular and tubulo-interstitial fibrosis, type 1 collagen expression and macrophage infiltration, as compared to rats treated with cyclosporine.The administration of C21 showed a protective effect on cyclosporine nephropathy, decreasing renal fibrosis and macrophage infiltration. These data suggest that C21 may counteract tubulo-interstitial fibrosis, the most potent predictor of the progression of renal diseases

Resource orchestration strategies with retrials for latency-sensitive network slicing over distributed telco clouds

The new radio technologies (i.e. 5G and beyond) will allow a new generation of innovative services operated by vertical industries (e.g. robotic cloud, autonomous vehicles, etc.) with more stringent QoS requirements, especially in terms of end-to-end latency. Other technological changes, such as Network Function Virtualization (NFV) and Software-Defined Networking (SDN), will bring unique service capabilities to networks by enabling flexible network slicing that can be tailored to the needs of vertical services. However, effective orchestration strategies need to be put in place to offer latency minimization while also maximizing resource utilization for telco providers to address vertical requirements and increase their revenue. Looking at this objective, this paper addresses a latency-sensitive orchestration problem by proposing different strategies for the coordinated selection of virtual resources (network, computational, and storage resources) in distributed DCs while meeting vertical requirements (e.g., bandwidth demand) for network slicing. Three orchestration strategies are presented to minimize latency or the blocking probability through effective resource utilization. To further reduce the slice request blocking, orchestration strategies also encompass a retrial mechanism applied to rejected slice requests. Regarding latency, two components were considered, namely processing and network latency. An extensive set of simulations was carried out over a wide and composite telco cloud infrastructure in which different types of data centers coexist characterized by a different network location, size, and processing capacity. The results compare the behavior of the strategies in addressing latency minimization and service request fulfillment, also considering the impact of the retrial mechanism.This work was supported in part by the Department of Excellence in Robotics and Artificial Intelligence by Ministero dell’Istruzione, dell’Università e della Ricerca (MIUR) to Scuola Superiore Sant’Anna, and in part by the Project 5GROWTH under Agreement 856709

The GRAAL high resolution BGO calorimeter and its energy calibration and monitoring system

We describe the electromagnetic calorimeter built for the GRAAL apparatus at the ESRF. Its monitoring system is presented in detail. Results from tests and the performance obtained during the first GRAAL experiments are given. The energy calibration accuracy and stability reached is a small fraction of the intrinsic detector resolution.Comment: 19 pages, 14 figures, submitted to Nuclear Instruments and Method

Introducing database communication technologies for TED replication in multi-domain networks

In multi-domain transport networks, exchange of Traffic Engineering information is required to enable effective end-to-end service provisioning and restoration by efficiently utilizing network resources. So far, several solutions have been proposed by the communication community such as the Hierarchical Path Computation Element (H-PCE) architecture. Using the H-PCE architecture a parent PCE is responsible for inter-domain path computation, while a dedicated child PCE performs intra-domain path computation within each domain. However, this approach can introduce scalability concerns especially under dynamic traffic condition such as during restoration because all path computation procedures are coordinated by the parent PCE and may require the exchange of many control messages. This paper proposes a standard communication among database systems located at the child PCEs, to exchange and share YANG-based Traffic Engineering information in multi-domain networks. By exploiting currently available database technologies, scalable and predictable performance is demonstrated for both replication mechanisms among child PCEs and information retrieval from the stored databases. Thus, this proposal enables the sharing of intra-domain information at each cPCE that can be locally used, upon failure, to speed-up the recovery procedure

Integrated Safety and Environment Group: Annual Report 2003

This report summarizes the main activities of the Integrated Safety and Environment (IE) Group of the Safety Commission (TIS) during the year 2003, and the results obtained. The different topics in which the group is active are covered: environment, quality management, safety training and major accidents follow-up

Study of prognosis in acute myeloid leukemias (AML) by cluster analysis

BACKGROUND. Cluster analysis is particularly effective in detecting homogeneous subgroups among large series of observations. We applied this relatively uncommon approach to the study of prognosis in 137 patients affected by acute myeloid leukemia (AML). METHODS AND RESULTS. Employing simple presentation parameters (age, WBC, splenomegaly, hepatomegaly) we used cluster analysis to define 3 groups with different overall survival (p = 0.0019). This classification was obtained following a rescaling of the variables and principal component analysis. Validation was performed through random definition of a control group. With the same variables, univariate analysis demonstrated age was the only prognostic factor, while Cox's model was not significant. CONCLUSIONS. In our series cluster analysis allowed a better definition of prognosis than Cox's analysis. Since the 3 groups are well identifiable, each patient can be rapidly classified and his allocation confirmed by discriminant functions. For cluster 2 we were able to project a possible myelodysplastic evolution, while cluster 3 was more frequently associated with a monocytic blastic component. We think that cluster analysis deserves consideration as an alternative statistical approach in the analysis of large series of data; its usefulness lies in its power to define homogeneous prognostic or biologic subgroups and to elaborate further hypotheses for new studies