Predicting short-term disability progression in early multiple sclerosis: Added value of MRI parameters

Objective: Magnetic resonance imaging (MRI) and clinical parameters are associated with disease progression in multiple sclerosis (MS). The aim of this study was to investigate whether adding MRI parameters to a model with only clinical parameters could improve these associations. Methods: 89 patients (55 women) with recently diagnosed MS had clinical and MRI evaluation at baseline (time of diagnosis) and at follow-up after 2.2 years. Detailed clinical data were available, including disease type (relapse-onset or progressive-onset) and disability, as measured by the Expanded Disability Status Scale (EDSS). MRI parameters included Normalised Brain Volume (NBV) at baseline, percentage brain volume change (PBVC/year), T2- and T1-lesion loads and spinal cord abnormalities. Progression of disability (increase in EDSS of at least 1 point at follow-up) was the main outcome measure. For a model containing only clinical parameters, the added value of MRI parameters was tested using logistic regression. Results: PBVC/year and lesion loads at follow-up were significantly higher in the group with progression. Adding PBVC/year to a clinical model improved the model, indicating that MRI parameters added independent information (p<0.001). Conclusion: The rate of cerebral atrophy conveys added information for the progression of disability in patients with early MS, suggesting that clinical disability is determined by neurodegenerative changes as depicted by MRI

Fermion zero modes at the boundary of superfluid 3He-B

Superfluid 3He-B belongs to the important special class of time-reversal invariant topological superfluids. It has Majorana fermions as edge states on the surface of bulk 3He-B. On the rough wall these fermion zero modes have finite density of states at E=0. It is possible that Lancaster experiments with a wire vibrating in 3He-B have already probed Majorana fermions living on the surface of the wire.Comment: 4 pages, no Figures, JETP Letters style, version to be published in JETP Letter

Critical Velocity in 3He-B Vibrating Wire Experiments as Analog of Vacuum Instability in a Slowly Oscillating Electric Field

The Lancaster experiments with a cylindrical wire moving in superfluid 3He-B are discussed, where the measured critical velocity of pair creation is much below the Landau critical velocity. The phenomenon is shown to be analogous to the instability of the electron-positron vacuum in an adiabatically alternating strong electric potential of both signs, where the positive- and negative-root levels cross and thus the instability treshold is twice less than in the conventional case of a single static potential well.Comment: RevTex file, 6 pages, 4 figure

Systematic investigation of the elastic proton-deuteron differential cross section at intermediate energies

To investigate the importance of three-nucleon forces (3NF) systematically over a broad range of intermediate energies, the differential cross sections of elastic proton-deuteron scattering have been measured at proton bombarding energies of 108, 120, 135, 150, 170 and 190 MeV at center-of-mass angles between $30^\circ$ and $170^\circ$. Comparisons with Faddeev calculations show unambiguously the shortcomings of calculations employing only two-body forces and the necessity of including 3NF. They also show the limitations of the latest few-nucleon calculations at backward angles, especially at higher beam energies. Some of these discrepancies could be partially due to relativistic effects. Data at lowest energy are also compared with a recent calculation based on \chipt

K^0 pi^0 Sigma^+ and K^*0 Sigma^+ photoproduction off the proton

The exclusive reactions $\gamma p \to K^{*0} \Sigma^+(1189)$ and $\gamma p \to K^{0} \pi^{0}\Sigma^+(1189)$, leading to the p 4$\pi^{0}$ final state, have been measured with a tagged photon beam for incident energies from threshold up to 2.5 GeV. The experiment has been performed at the tagged photon facility of the ELSA accelerator (Bonn). The Crystal Barrel and TAPS detectors were combined to a photon detector system of almost 4$\pi$ geometrical acceptance. Differential and total cross sections are reported. At energies close to the threshold, a flat angular distribution has been observed for the reaction $\gamma p\to K^{0} \pi^{0}\Sigma^+$ suggesting dominant s-channel production. $\Sigma^*(1385)$ and higher lying hyperon states have been observed. An enhancement in the forward direction in the angular distributions of the reaction $\gamma p \to K^{*0}\Sigma^+$ indicates a $t$-channel exchange contribution to the reaction mechanism. The experimental data are in reasonable agreement with recent theoretical predictions.Comment: 11 pages, 13 figures, submitted to EPJ

Topological superfluid 3He-B in magnetic field and Ising variable

The topological superfluid 3He-B provides many examples of the interplay of symmetry and topology. Here we consider the effect of magnetic field on topological properties of 3He-B. Magnetic field violates the time reversal symmetry. As a result, the topological invariant supported by this symmetry ceases to exist; and thus the gapless fermions on the surface of 3He-B are not protected any more by topology: they become fully gapped. Nevertheless, if perturbation of symmetry is small, the surface fermions remain relativistic with mass proportional to symmetry violating perturbation -- magnetic field. The 3He-B symmetry gives rise to the Ising variable I=+/- 1, which emerges in magnetic field and which characterizes the states of the surface of 3He-B. This variable also determines the sign of the mass term of surface fermions and the topological invariant describing their effective Hamiltonian. The line on the surface, which separates the surface domains with different I, contains 1+1 gapless fermions, which are protected by combined action of symmetry and topology.Comment: 5 pages, JETP Letters style, no figures, version submitted to JETP Letter

Evolution of edge states in topological superfluids during the quantum phase transition

The quantum phase transition between topological and non-topological insulators or between fully gapped superfluids/superconductors can occur without closing the gap. We consider the evolution of the Majorana edge states on the surface of topological superconductor during transition to the topologically trivial superconductor on example of non-interacting Hamiltonian describing the spin-triplet superfluid 3He-B. In conventional situation when the gap is nullified at the transition, the spectrum of Majorana fermions shrinks and vanishes after the transition to the trivial state. If the topological transition occurs without the gap closing, the Majorana fermion spectrum disappears by escaping to ultraviolet, where Green's function approaches zero. This demonstrates the close connection between the topological transition without closing the gap and zeroes in the Green's function. Similar connection takes place in interacting systems where zeroes may occur due to interaction.Comment: 5 pages, 2 figures, JETP Letters style, version submitted to JETP Letter