Sola Scriptura : hindrance or catalyst for church unity?

In the Reformed tradition sola Scriptura remains a central tenet in the search for truth. Scripture bears witness to the variety of ways in which God has acted in history. It attests to God’s presence in the world and how God transcends the boundaries of human creations. The article focuses on how the Bible is interpreted differently by Christians from various traditions and even amongst Christians of the same tradition. Different hermeneutical approaches, confessional traditions and cultural contexts lead to different conclusions. Especially with regard to controversial ethical issues, different approaches to biblical reasoning lead to greatly differing results. The article reflects on whether sola Scriptura could provide a key to addressing both diversity and ethics more adequately.http://www.hts.org.zaam2013mn201

Sola Scriptura : hindrance or catalyst for church unity?

In the Reformed tradition sola Scriptura remains a central tenet in the search for truth. Scripture bears witness to the variety of ways in which God has acted in history. It attests to God’s presence in the world and how God transcends the boundaries of human creations. The article focuses on how the Bible is interpreted differently by Christians from various traditions and even amongst Christians of the same tradition. Different hermeneutical approaches, confessional traditions and cultural contexts lead to different conclusions. Especially with regard to controversial ethical issues, different approaches to biblical reasoning lead to greatly differing results. The article reflects on whether sola Scriptura could provide a key to addressing both diversity and ethics more adequately.http://www.hts.org.zaam2013mn201

Why boys will be boys: two pathways of fetal testicular androgen biosynthesis are needed for male sexual differentiation

Human sexual determination is initiated by a cascade of genes that lead to the development of the fetal gonad. Whereas development of the female external genitalia does not require fetal ovarian hormones, male genital development requires the action of testicular testosterone and its more potent derivative dihydrotestosterone (DHT). The "classic" biosynthetic pathway from cholesterol to testosterone in the testis and the subsequent conversion of testosterone to DHT in genital skin is well established. Recently, an alternative pathway leading to DHT has been described in marsupials, but its potential importance to human development is unclear. AKR1C2 is an enzyme that participates in the alternative but not the classic pathway. Using a candidate gene approach, we identified AKR1C2 mutations with sex-limited recessive inheritance in four 46,XY individuals with disordered sexual development (DSD). Analysis of the inheritance of microsatellite markers excluded other candidate loci. Affected individuals had moderate to severe undervirilization at birth; when recreated by site-directed mutagenesis and expressed in bacteria, the mutant AKR1C2 had diminished but not absent catalytic activities. The 46,XY DSD individuals also carry a mutation causing aberrant splicing in AKR1C4, which encodes an enzyme with similar activity. This suggests a mode of inheritance where the severity of the developmental defect depends on the number of mutations in the two genes. An unrelated 46,XY DSD patient carried AKR1C2 mutations on both alleles, confirming the essential role of AKR1C2 and corroborating the hypothesis that both the classic and alternative pathways of testicular androgen biosynthesis are needed for normal human male sexual differentiation