Bostonia: The Boston University Alumni Magazine. Volume 26

Founded in 1900, Bostonia magazine is Boston University's main alumni publication, which covers alumni and student life, as well as university activities, events, and programs

Bostonia: The Boston University Alumni Magazine. Volume 29

Founded in 1900, Bostonia magazine is Boston University's main alumni publication, which covers alumni and student life, as well as university activities, events, and programs

Over-expressed copper/zinc superoxide dismutase localizes to mitochondria in neurons inhibiting the angiotensin II-mediated increase in mitochondrial superoxide

Angiotensin II (AngII) is the main effector peptide of the renin-angiotensin system (RAS), and contributes to the pathogenesis of cardiovascular disease by exerting its effects on an array of different cell types, including central neurons. AngII intra-neuronal signaling is mediated, at least in part, by reactive oxygen species, particularly superoxide (O2 (•-)). Recently, it has been discovered that mitochondria are a major subcellular source of AngII-induced O2 (•-). We have previously reported that over-expression of manganese superoxide dismutase (MnSOD), a mitochondrial matrix-localized O2 (•-) scavenging enzyme, inhibits AngII intra-neuronal signaling. Interestingly, over-expression of copper/zinc superoxide dismutase (CuZnSOD), which is believed to be primarily localized to the cytoplasm, similarly inhibits AngII intra-neuronal signaling and provides protection against AngII-mediated neurogenic hypertension. Herein, we tested the hypothesis that CuZnSOD over-expression in central neurons localizes to mitochondria and inhibits AngII intra-neuronal signaling by scavenging mitochondrial O2 (•-). Using a neuronal cell culture model (CATH.a neurons), we demonstrate that both endogenous and adenovirus-mediated over-expressed CuZnSOD (AdCuZnSOD) are present in mitochondria. Furthermore, we show that over-expression of CuZnSOD attenuates the AngII-mediated increase in mitochondrial O2 (•-) levels and the AngII-induced inhibition of neuronal potassium current. Taken together, these data clearly show that over-expressed CuZnSOD in neurons localizes in mitochondria, scavenges AngII-induced mitochondrial O2 (•-), and inhibits AngII intra-neuronal signaling

Bostonia: The Boston University Alumni Magazine. Volume 34

Founded in 1900, Bostonia magazine is Boston University's main alumni publication, which covers alumni and student life, as well as university activities, events, and programs

BUMC Annual Report

Annual report of the Boston University Medical Center

Bostonia: The Boston University Alumni Magazine. Volume 25

Founded in 1900, Bostonia magazine is Boston University's main alumni publication, which covers alumni and student life, as well as university activities, events, and programs

Preventing farm land price inflation in the midwest

Both a recollection of the disastrous consequences of the inflationary land prices following World War I and recognition o f the possibility of a recurrence have stimulated public interest in information about the current farm real estate situation. This report has been prepared by the North Central Regional Land Tenure Committee for the purpose of presenting an appraisal of the current situation, stimulating discussion of the problems, and outlining the various possible lines of action most often suggested for curbing undesirable developments. The North Central Regional Land Tenure Committee came into existence as the result o f an informal conference sponsored by the Farm Foundation in the spring of 1939 for land economists from the agricultural experiment stations in the Midwest. As an outgrowth of this and subsequent meetings, the director of each station appointed one of his staff to the Regional Land Tenure Committee which also includes representatives from the United States Department of Agriculture. The major function of the committee is to develop an integrated long-time program of research that will lead to the improvement of farm tenure in the region. This report pertaining to land price inflation in the Midwest is the committee’s second formal publication. The first was entitled “Improving Farm Tenure in the Midwest” and was published as Illinois Agricultural Experiment Station Bulletin 502. The present bulletin is based not only on reports collected from sample counties but on observation and study of the situation by at least one representative from each of the participating states. It is impractical to cite specific land market material published by the several cooperating institutions, but such information is available upon request to the participating agencies

Bostonia: The Boston University Alumni Magazine. Volume 32

Founded in 1900, Bostonia magazine is Boston University's main alumni publication, which covers alumni and student life, as well as university activities, events, and programs

BMQ

BMQ: Boston Medical Quarterly was published from 1950-1966 by the Boston University School of Medicine and the Massachusetts Memorial Hospitals