276 research outputs found
Isoforme specifiche di p38 implicate nella termotolleranza e nella risposta a differenti stress nell'embrione di riccio di mare
Intracellular calcium accumulation and responsiveness to progesterone in capacitating human spermatozoa.
Polarization Asymmetry In The Photodisintegration Of The Deuteron
The reaction ²(γ,p)n has been studied using a monochromatic and polarized gamma ray beam at energies E(γ)=19.8, 29.0, 38.6, and 60.8 MeV. The beam of an intensity ∼4×10⁵ γ/sec was obtained by Compton back scattering of mode-locked laser light off electron bunches in the Adone storage ring. Photoneutron yields were measured at nine neutron angles thetan≃15, 30, 45, 60, 90, 120, 135, 150, and 165 deg in the center of mass (c.m.) for E(γ)=19.8, 29.0, and 38.6 MeV, and at thetan≃30, 60, 90, 120, and 150 deg c.m. for E(γ)=60.8 MeV. The polarization independent component Iₒ(theta) of the differential cross section and the polarization dependent component PI₁(theta) were deduced and the angular distribution of the azimuthal asymmetry factor Σ(theta)=I₁(theta)/Iₒ(theta) was obtained. An extensive comparison with theory has been carried out and the inclusion of corrections due to meson exchange currents and to Δ-isobar configurations have been shown to be mandatory at energies E(γ)≳40 MeV. Theoretical and experimental implications of intermediate energy deuteron photo- disintegration studies are discussed in some detail
The GRAAL high resolution BGO calorimeter and its energy calibration and monitoring system
We describe the electromagnetic calorimeter built for the GRAAL apparatus at
the ESRF. Its monitoring system is presented in detail. Results from tests and
the performance obtained during the first GRAAL experiments are given. The
energy calibration accuracy and stability reached is a small fraction of the
intrinsic detector resolution.Comment: 19 pages, 14 figures, submitted to Nuclear Instruments and Method
Cannabidiol skews biased agonism at cannabinoid CB1 and CB2 receptors with smaller effect in CB1-CB2 heteroreceptor complexes
Currently, biased agonism is at the center stage of drug development approaches. We analyzed effects of a battery of cannabinoids plus/minus cannabidiol (CBD) in four functional parameters (cAMP levels, phosphorylation of extracellular signal–regulated kinases (ERK1/2), β-arrestin recruitment and label-free/DMR) in HEK-293T cells expressing cannabinoid receptors, CB or CB, or CB-CB heteroreceptor complexes. In all cases two natural agonists plus two selective synthetic agonists were used. Furthermore, the effect of cannabidiol, at a dose (100 nM) that does not allow significant binding to the orthosteric center of either receptor, was measured. From the huge amount of generated data, we would like to highlight that the two psychotropic molecules (Δ-tetrahydrocannabinol/THC and CP-55940) showed similar bias in CBR and that the bias of THC was particularly relevant toward MAPK pathway. Furthermore, THC did not activate the G protein coupled to CBR. Interestingly, the biased agonism was reduced when assays were performed in cells expressing the two receptors, thus suggesting that the heteromer allows less functional selectivity. In terms of cannabidiol action, the phytocannabinoid altered the functional responses, likely by allosteric means, and modified potency, agonist IC/EC values and biased agonism in qualitative and/or quantitative different ways depending on the agonist. The effect of cannabidiol on anandamide actions on both cannabinoid receptors was particularly noteworthy as was significantly different from that of other compounds. Results are a compendium of data on biased agonism on cannabinoid receptors in the absence and presence of cannabidiol. In addition, for the first time, GPCR biased agonism is characterized in an heteromeric context.This work was partially supported by grants from the Spanish
Ministry of Economy and Competitiveness (Ref. no. BFU2015-64405-R
and SAF2017-84117-R; they may include FEDER funds) and by grant
201413-30 from: Fundació la Marató de TV3Peer Reviewe
Limits on light-speed anisotropies from Compton scattering of high-energy electrons
The possibility of anisotropies in the speed of light relative to the
limiting speed of electrons is considered. The absence of sidereal variations
in the energy of Compton-edge photons at the ESRF's GRAAL facility constrains
such anisotropies representing the first non-threshold collision-kinematics
study of Lorentz violation. When interpreted within the minimal Standard-Model
Extension, this result yields the two-sided limit of 1.6 x 10^{-14} at 95%
confidence level on a combination of the parity-violating photon and electron
coefficients kappa_{o+} and c. This new constraint provides an improvement over
previous bounds by one order of magnitude.Comment: 4 pages, 4 figure
Polarization asymmetry in the photodisintegration of the deuteron
The reaction ²(γ,p)n has been studied using a monochromatic and polarized gamma ray beam at energies E(γ)=19.8, 29.0, 38.6, and 60.8 MeV. The beam of an intensity ∼4×10⁵ γ/sec was obtained by Compton back scattering of mode-locked laser light off electron bunches in the Adone storage ring. Photoneutron yields were measured at nine neutron angles thetan≃15, 30, 45, 60, 90, 120, 135, 150, and 165 deg in the center of mass (c.m.) for E(γ)=19.8, 29.0, and 38.6 MeV, and at thetan≃30, 60, 90, 120, and 150 deg c.m. for E(γ)=60.8 MeV. The polarization independent component Iₒ(theta) of the differential cross section and the polarization dependent component PI₁(theta) were deduced and the angular distribution of the azimuthal asymmetry factor Σ(theta)=I₁(theta)/Iₒ(theta) was obtained. An extensive comparison with theory has been carried out and the inclusion of corrections due to meson exchange currents and to Δ-isobar configurations have been shown to be mandatory at energies E(γ)≳40 MeV. Theoretical and experimental implications of intermediate energy deuteron photo- disintegration studies are discussed in some detail
Enhanced Intersystem Crossing and Transient Electron Spin Polarization in a Photoexcited Pentacene-Trityl Radical
Stimulation of platelet-activating factor synthesis by progesterone and A23187 in human spermatozoa
Measurement of eta photoproduction on the proton from threshold to 1500 MeV
Beam asymmetry and differential cross section for the reaction gamma+p->eta+p
were measured from production threshold to 1500 MeV photon laboratory energy.
The two dominant neutral decay modes of the eta meson, eta->2g and eta->3pi0,
were analyzed. The full set of measurements is in good agreement with
previously published results. Our data were compared with three models. They
all fit satisfactorily the results but their respective resonance contributions
are quite different. The possible photoexcitation of a narrow state N(1670) was
investigated and no evidence was found.Comment: 18 pages, 14 figures, 4 tables Submitted to EPJ
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