Local and regional influences over soil microbial metacommunities in the Transantarctic Mountains

The metacommunity concept provides a useful framework to assess the influence of local and regional controls over diversity patterns. Culture‐independent studies of soil microbial communities in the McMurdo Dry Valleys of East Antarctica (77° S) have shown that bacterial diversity is related to soil geochemical gradients, while studies targeting edaphic cyanobacteria have linked local diversity patterns to dispersal‐based processes. In this study, we increased the spatial extent of observed soil microbial communities to cover the Beardmore Glacier region in the central Transantarctic Mountains (84° S). We used community profiling techniques to characterize diversity patterns for bacteria and the cyanobacterial subcomponent of the microbial community. Diversity partitioning was used to calculate beta diversity and estimate among‐site dissimilarity in the metacommunity. We then used variation partitioning to assess the relationship between beta diversity and environmental and spatial gradients. We found that dominant groups in the soil bacterial metacommunity were influenced by gradients in pH and soil moisture at the Transantarctic scale (800 km). Conversely, beta diversity for the cyanobacterial component of the edaphic microbial metacommunity was decoupled from these environmental gradients, and was more related to spatial filters, suggesting that wind‐driven dispersal dynamics created cyanobacterial biogeography at a local scale (<3 km)

Characterization of covalent inhibitors that disrupt the interaction between the tandem SH2 domains of SYK and FCER1G phospho-ITAM

RNA sequencing and genetic data support spleen tyrosine kinase (SYK) and high affinity immunoglobulin epsilon receptor subunit gamma (FCER1G) as putative targets to be modulated for Alzheimer’s disease (AD) therapy. FCER1G is a component of Fc receptor complexes that contain an immunoreceptor tyrosine-based activation motif (ITAM). SYK interacts with the Fc receptor by binding to doubly phosphorylated ITAM (p-ITAM) via its two tandem SH2 domains (SYK-tSH2). Interaction of the FCER1G p-ITAM with SYK-tSH2 enables SYK activation via phosphorylation. Since SYK activation is reported to exacerbate AD pathology, we hypothesized that disruption of this interaction would be beneficial for AD patients. Herein, we developed biochemical and biophysical assays to enable the discovery of small molecules that perturb the interaction between the FCER1G p-ITAM and SYKtSH2. We identified two distinct chemotypes using a high-throughput screen (HTS) and orthogonally assessed their binding. Both chemotypes covalently modify SYK-tSH2 and inhibit its interaction with FCER1G p-ITAM, however, these compounds lack selectivity and this limits their utility as chemical tools

Internet teaching foundation for the Remote Sensing Core Curriculum program

The Remote Sensing Core Curriculum (RSCC) was initiated in 1993 to meet the demands for a college-level set of resources to enhance the quality of education across national and international campuses. The American Society of Photogrammetry and Remote Sensing adopted the RSCC in 1996 to sustain support of this educational initiative for its membership and collegiate community. A series of volumes, containing lectures, exercises, and data, is being created by expert contributors to address the different technical fields of remote sensing. The RSCC program is designed to operate on the Internet taking full advantage of the World Wide Web (WWW) technology for distance learning. The issues of curriculum development related to the educational setting, with demands on faculty, students, and facilities, is considered to understand the new paradigms for WWW-influenced computer-aided learning. The WWW is shown to be especially appropriate for facilitating remote sensing education with requirements for addressing image data sets and multimedia learning tools. The RSCC is located at http://www.umbc.edu/rscc. The Remote Sensing Core Curriculum (RSCC) was initiated in 1993 to meet the demands for a college-level set of resources to enhance the quality of education across national and international campuses. The American Society of Photogrammetry and Remote Sensing adopted the RSCC in 1996 to sustain support of this educational initiative for its membership and collegiate community. A series of volumes, containing lectures, exercises, and data, is being created by expert contributors to address the different technical fields of remote sensing. The RSCC program is designed to operate on the Internet taking full advantage of the World Wide Web (WWW) technology for distance learning. The issues of curriculum development related to the educational setting, with demands on faculty, students, and facilities, is considered to understand the new paradigms for WWW-influenced computer-aided learning. The WWW is shown to be especially appropriate for facilitating remote sensing education with requirements for addressing image data sets and multimedia learning tools. The RSCC is located at http://www.umbc.edu/rscc

Entropy and sustainability

Soil-plant systems exchange both energy and matter with their surroundings and are consequently open systems thermodynamically. They should therefore tend towards a steady state described by non-equilibrium thermodynamics and characterized by minimum production of entropy. The theory surrounding the principle of minimum entropy production provides a good analogue of the behaviour of natural and agricultural ecosystems subjected to perturbations. Entropy-increasing processes are those that degrade complex, ordered structures of large molecular weight to small molecules such as CO2, NH3 and H2O. Processes such as photosynthesis that build small molecules into larger ones lessen entropy. These ordering processes are permitted by thermodynamic work performed when heat is transferred from the sun. They depend critically on the capacity of the system for self-organization, which is identified with its biological potential. Several of the small molecules are environmentally undesirable in excess. This, together with the theoretical considerations above, suggests that minimum production of entropy should be a criterion of sustainability. It implies that agricultural systems should be allowed to become steady states where possible and that maintaining the biological potential is essential. An 'audit of small molecules' is suggested as a way of assessing sustainability