A silicon model of auditory localization

The barn owl accurately localizes sounds in the azimuthal plane, using interaural time difference as a cue. The time-coding pathway in the owl's brainstem encodes a neural map of azimuth, by processing interaural timing information. We have built a silicon model of the time-coding pathway of the owl. The integrated circuit models the structure as well as the function of the pathway; most subcircuits in the chip have an anatomical correlate. The chip computes all outputs in real time, using analog, continuous-time processing

Interstate Water Compacts

33 pages. Contains references

Interstate Water Compacts

33 pages. Contains references

Letter to the Editor: a response to Horne and Lucey (2017)

No abstract available

Small heat-shock proteins: important players in regulating cellular proteostasis

Small heat-shock proteins (sHsps) are a diverse family of intra-cellular molecular chaperone proteins that play a critical role in mitigating and preventing protein aggregation under stress conditions such as elevated temperature, oxidation and infection. In doing so, they assist in the maintenance of protein homeostasis (proteostasis) thereby avoiding the deleterious effects that result from loss of protein function and/or protein aggregation. The chaperone properties of sHsps are therefore employed extensively in many tissues to prevent the development of diseases associated with protein aggregation. Significant progress has been made of late in understanding the structure and chaperone mechanism of sHsps. In this review, we discuss some of these advances, with a focus on mammalian sHsp hetero-oligomerisation, the mechanism by which sHsps act as molecular chaperones to prevent both amorphous and fibrillar protein aggregation, and the role of post-translational modifications in sHsp chaperone function, particularly in the context of disease.SM was supported by a Royal Society Dorothy Hodgkin Fellowship, HE is supported by an Australian Research Council Future Fellowship (FT110100586) and JC is supported by a National Health and Medical Research Council Project Grant (#1068087)