3D Multi-Material Laser Powder Bed Fusion: a disruptive approach to design/manufacture unparalleled multi-functional solutions

[Excerpt] Engineering has been so far a mono-dimension tool where components are mono-material, dense unoptimized and designed for one or two requirements, due to processes’ limitations. Traditional components diverge entirely from lightweight and multi-material nature structures endowed with a high level of multi-functionality. [...]This work was supported by FCT national funds, under the national support to R&D units grant, through the reference projects UIDB/04436/2020 and UIDP/04436/2020

Phylogenetic relationships of Chanidae (Teleostei: Gonorynchiformes) as impacted by Dastilbe moraesi, from the Sanfranciscana basin, Early Cretaceous of Brazil

Fossil gonorynchiform fishes range from the Lower Cretaceous to the early Miocene, and are represented by a few dozen living species. The order is currently divided into two major clades: Gonorynchoidei, which includes the families Gonorynchidae and Kneriidae, and Chanoidei, encompassing a single family, Chanidae, with a single recent species, the Indo-Pacific Chanos chanos, and several fossil taxa. Chanidae includes some poorly known taxa, such as Dastilbe moraesi, described from the Aptian (Lower Cretaceous) of the Areado Formation, Sanfranciscana basin, Brazil. This species is currently considered to be a junior synonym of the type species of its genus, Dastilbe crandalli, from Santana Formation, Aptian, northeastern Brazil. The analysis of abundant D. moraesi specimens revealed several new morphological features, many of which had previously been misinterpreted. Dastilbe moraesi was incorporated into a gonorynchiform character matrix as revised and modified for the Chanidae. We obtained a single most parsimonious tree in which D. moraesi is distinct and phylogenetically apart from D. crandalli. According our analysis, D. moraesi forms a sister pair with Chanos, a clade which is closely related to Tharrhias, all composing the tribe ChaniniGonorynchiformes fósseis ocorrem desde do Cretáceo inferior ao Mioceno inferior, e são representados por alguns representantes viventes. A ordem está dividida atualmente em dois clados principais: Gonorynchoidei, que inclui as famílias Gonorynchidae e Kneriidae, e Chanoidei, compreendendo uma única família, Chanidae, com uma única espécie vivente, Chanos chanos, do Indo-Pacífico, além de vários representantes fósseis. Chanidae inclui alguns táxons problemáticos, tais como Dastilbe moraesi, descrito do Aptiano (Cretáceo Inferior) da Formação Areado, bacia Sanfranciscana, Brasil. Esta espécie é atualmente considerada um sinônimo júnior da espécie-tipo de seu gênero, Dastilbe crandalli, da Formação Santana, Aptiano do nordeste do Brasil. A análise de abundante material de D. moraesi revelou várias novas características anatômicas, muitas das quais haviam sido previamente mal interpretadas. Dastilbe moraesi foi incorporado em uma matriz revisada de caracteres da família Chanidae. Nós obtivemos uma única árvore mais parcimoniosa na qual D. moraesi é distinto e filogeneticamente distante de D. crandalli. De acordo com nossa análise, D. moraesi é o grupo-irmão de Chanos, um clado intimamente relacionado a Tharrhias, com todos compondo a tribo ChaniniThis study was supported by CNPq (process # 401818/2010-1) and project CGL2013-42643P, Ministerio de Ciencia e Innovación de Españ

Central Neurogenic Respiratory Failure: A Challenging Diagnosis

Background: Central nervous system lesions are rare causes of respiratory failure. Simple observation of the breathing pattern can help localize the lesion, but the examiner needs to be aware of potential pitfalls such as metabolic or pulmonary alterations. Methods: We describe 3 cases in which central neurogenic respiratory failure occurred simultaneously with other alterations or in an unusual presentation. Results: All patients were diagnosed with central neurogenic respiratory failure and treated for it with good recovery. Conclusion: Central neurogenic respiratory failure is a challenging diagnosis and needs to be reminded in difficult-to-wean patients carrying inconclusive evidences of metabolic or pulmonary alterations

Pressure-induced Colossal Magnetocaloric Effect In Mnas.

To present day, the maximum magnetocaloric effect (MCE) at room temperature for a magnetic field change of 5 T is 40 J/(kg K) for MnAs. In this Letter we present colossal MCE measurements on MnAs under pressure, reaching values up to 267 J/(kg K), far greater than the magnetic limit arising from the assumption of magnetic field independence of the lattice and electronic entropy contributions. The origin of the effect is the contribution to the entropy variation coming from the lattice through the magnetoelastic coupling.9323720

Obtaining high purity silica from rice hulls

Many routes for extracting silica from rice hulls are based on direct calcining. These methods, though, often produce silica contaminated with inorganic impurities. This work presents the study of a strategy for obtaining silica from rice hulls with a purity level adequate for applications in electronics. The technique is based on two leaching steps, using respectively aqua regia and Piranha solutions, which extract the organic matrix and inorganic impurities. The material was characterized by Fourier-transform infrared spectroscopy (FTIR), powder x-ray diffraction (XRD), x-ray fluorescence (XRF), scanning electron microscopy (SEM), particle size analysis by laser diffraction (LPSA) and thermal analysis

Venous Blood Derivatives as FBSSubstitutes for Mesenchymal Stem Cells: A Systematic Scoping Review

Although the biological properties of mesenchymal stem cells (MSC) are well-characterized in vitro, MSC clinical application is still far away to be achieved, mainly due to the need of xenogeneic substances for cell expansion, such as fetal bovine serum (FBS). FBS presents risks regarding pathogens transmissions and internalization of animal’s proteins, which can unleash antigenic responses in patients after MSC implantation. A wide range of venous blood derivatives (VBD) has been reported as FBS substitutes showing promising results. Thus, the aim of this study was to conduct a systematic scoping review to analyze whether VBD are effective FBS substitutes for MSC ex vivo expansion. The search was performed in SciVerse ScopusTM, PubMed, Web of ScienceTM, BIREME, Cochrane library up to January 2016. The keywords were selected using MeSH and entry terms. Two independent reviewers scrutinized the records obtained considering specific inclusion criteria. The included studies were evaluated in accordance with a modified Arksey and O’ Malley’s framework. From 184 found studies, 90 were included. Bone marrow mesenchymal stem cells (BMMSC) were presented in most of these studies. Overall, VBD allowed for either, maintenance of MCS’s fibroblast-like morphology, high proliferation, high colony-formation ability and maintenance of multipotency. Besides. MSC expanded in VBD supplements presented higher mitogen activity than FBS. VBD seems to be excellent xeno-free serum for ex vivo expansion of mesenchymal stem cells. However, an accentuated heterogeneity was observed between the carried out protocols for VBD isolation did not allowing for direct comparisons between the included studies

Módulos multimídia para o ensino de sistemas de telecomunicações

A tecnologia multimídia fornece elementos para uma concepção integridade transmissão do conhecimento, onde se exige maior comprometimento por parte do aluno, aumentando a sua responsabilidade, encorajando-o ao controle do seu aprendizado. A capacidade de combinar aplicações práticas, visualizações de fenômenos complexos, laboratórios virtuais, animações e a utilização auto assistida de aplicativos de simulação são algumas das vantagens da educação baseada em técnicas multimídia. Este trabalho descreve o desenvolvimento de um ambiente multimídia na forma de CD-ROM, para a área de Sistemas de Telecomunicações. OCD-ROM foi concebido para ser utilizado em atividades de extensão, de maneira a facilitar a aprendizagem e atualização do estudante, de forma mais descentralizada, considerando seus interesses e sua disponibilidade

Eikonal profile functions and amplitudes for pp\rm pp and pˉp\bar{\rm p}{\rm p} scattering

The eikonal profile function $J(b)$ obtained from the Model of the Stochastic Vacuum is parametrized in a form suitable for comparison with experiment. The amplitude and the extended profile function (including imaginary and real parts) are determined directly from the complete pp and $\bar{\rm p}$p elastic scattering data at high energies. Full and accurate representation of the data is presented, with smooth energy dependence of all parameters. The changes needed in the original profile function required for description of scattering beyond the forward direction are described.Comment: Latex, 28 pages and 16 figure

Hipertensão arterial sistêmica secundária

The prevalence of secondary systemic arterial hypertension (S-SAH) is 3% to 5%. Before investigating the secondary causes of SAH, the following should be excluded: ._ Inadequate measurement of arterial pressure (AP). ._ White-coat hypertension; ._ Inadequate treatment; ._ Treatment non-adherence; ._ Progression of lesions in hypertension target organs; ._ Presence of co-morbidities; ._ Interaction with prescription drugs. Table 1 lists the situations when the presence of S-SAH should be investigated. Next, the main causes of S-SAH will be discussed. [Author supplied abstract

Tratamento farmacológico das doenças reumáticas

Apresenta-se, nesta revisão, a terapêutica farmacológica atual das doenças reumáticas de adultos, do modo como é conduzida na Divisão de Imunologia Clínica do Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto, da Universidade de São Paulo. Enfatizam-se a seleção de drogas, as respostas clínicas e o monitoramento terapêutico das principais doenças reumáticas. Entre estas, incluem-se tanto as de patogênese auto-imune (artrite reumatóide, lúpus eritematoso sistêmico, febre reumática, espondilartropatias, esclerose sistêmica, dermatopolimiosite, vasculites), como as não-imunológicas (gota, pseudogota, osteoartrose, osteoporose e fibromialgia).We review here the current pharmacologic therapy of rheumatic diseases in adults as conducted by the Division of Clinical Immunology of the University Hospital of the School of Medicine of Ribeirão Preto of the University of São Paulo. Emphasis is posed on drug selection, clinical responses and therapeutic monitoring of leading rheumatic diseases. Among them are included those with autoimmune ethiopathogenesis (rheumatoid arthritis, systemic lupus erythematosus, rheumatic fever, spondyloarthropathies, systemic sclerosis, dermatopolymyositis and the vasculitis) and those without immunological nature (gout, pseudogout, osteoarthrosis, osteoporosis and fibromyalgia)