Can pictures have explicatures?

This paper considers the question of whether pictures can be understood to give rise to explicit meanings. In relevance-theoretic terms, this means asking whether pictures give rise to ‘explicatures’. The definition of the term ‘explicature’ seems to rule out this possibility except in cases where pictures include or are accompanied by material with coded meanings. The paper considers a range of non-verbal phenomena with coded meanings, including pictograms (Forceville 2011, Forceville et al 2014). It then considers whether the explicature-implicature distinction could be relevant to pictures without such elements. Some assumptions communicated by pictures seem to be more ‘explicature-like’ than others, so it is possible that the distinction will be useful. The question is not merely terminological as the discussion leads to a fuller understanding of ways in which pictures communicate

Unrelated marrow transplantation for adult patients with poor-risk acute lymphoblastic leukemia: strong graft-versus-leukemia effect and risk factors determining outcome

Between 1988 and 1999, 127 patients with poor-risk acute lymphoblastic leukemia (ALL) received a matched unrelated donor transplant using marrow procured by National Marrow Donor Program (NMDP) collection centers and sent out to 46 transplant centers worldwide. Poor risk was defined by the presence of the translocations t(9;22) (n = 97), or t(4;11) (n = 25), or t(1;19) (n = 5). Sixty-four patients underwent transplantation in first remission (CR1), 16 in CR2 or CR3, and 47 patients had relapsed ALL or primary induction failure (PIF). Overall survival at 2 years from transplant was 40% for patients in CR1, 17% in CR2/3, and 5% in PIF or relapse. Treatment-related mortality (TRM) and relapse mortality, estimated as competing risk factors, were 54% and 6%, respectively, in CR1, 75% and 8% in CR2/3, and 64% and 31% in PIF or relapse. Currently 23 CR1 patients are alive and free of disease with a median follow-up of 24 months (range, 3-97). Multivariable analysis showed that CR1, shorter interval from di

Some , And Possibly All, Scalar Inferences Are Not Delayed: Evidence For Immediate Pragmatic Enrichment

Scalar inferences are commonly generated when a speaker uses a weaker expression rather than a stronger alternative, e.g., John ate some of the apples implies that he did not eat them all. This article describes a visual-world study investigating how and when perceivers compute these inferences. Participants followed spoken instructions containing the scalar quantifier some directing them to interact with one of several referential targets (e.g., Click on the girl who has some of the balloons). Participants fixated on the target compatible with the implicated meaning of some and avoided a competitor compatible with the literal meaning prior to a disambiguating noun. Further, convergence on the target was as fast for some as for the non-scalar quantifiers none and all. These findings indicate that the scalar inference is computed immediately and is not delayed relative to the literal interpretation of some. It is argued that previous demonstrations that scalar inferences increase processing time are not necessarily due to delays in generating the inference itself, but rather arise because integrating the interpretation of the inference with relevant information in the context may require additional time. With sufficient contextual support, processing delays disappear

Distinguishing Speed From Accuracy In Scalar Implicatures

Scalar implicatures are inferences that arise when a weak expression is used instead of a stronger alternative. For example, when a speaker says, “Some of the children are in the classroom,” she often implies that not all of them are. Recent processing studies of scalar implicatures have argued that generating an implicature carries a cost. In this study we investigated this cost using a sentence verification task similar to that of Bott and Noveck (2004) combined with a response deadline procedure to estimate speed and accuracy independently. Experiment 1 compared implicit upper-bound interpretations (some [but not all]) with lower-bound interpretations (some [and possibly all]). Experiment 2 compared an implicit upper-bound meaning of some with the explicit upper-bound meaning of only some. Experiment 3 compared an implicit lower-bound meaning of some with the explicit lower-bound meaning of at least some. Sentences with implicatures required additional processing time that could not be attributed to retrieval probabilities or factors relating to semantic complexity. Our results provide evidence against several different types of processing models, including verification and nonverification default implicature models and cost-free contextual models. More generally, our data are the first to provide evidence of the costs associated with deriving implicatures per se

E. coli Histidine Triad Nucleotide Binding Protein 1 (ecHinT) Is a Catalytic Regulator of D-Alanine Dehydrogenase (DadA) Activity In Vivo

Histidine triad nucleotide binding proteins (Hints) are highly conserved members of the histidine triad (HIT) protein superfamily. Hints comprise the most ancient branch of this superfamily and can be found in Archaea, Bacteria, and Eukaryota. Prokaryotic genomes, including a wide diversity of both Gram-negative and Gram-positive bacteria, typically have one Hint gene encoded by hinT (ycfF in E. coli). Despite their ubiquity, the foundational reason for the wide-spread conservation of Hints across all kingdoms of life remains a mystery. In this study, we used a combination of phenotypic screening and complementation analyses with wild-type and hinT knock-out Escherichia coli strains to show that catalytically active ecHinT is required in E. coli for growth on D-alanine as a sole carbon source. We demonstrate that the expression of catalytically active ecHinT is essential for the activity of the enzyme D-alanine dehydrogenase (DadA) (equivalent to D-amino acid oxidase in eukaryotes), a necessary component of the D-alanine catabolic pathway. Site-directed mutagenesis studies revealed that catalytically active C-terminal mutants of ecHinT are unable to activate DadA activity. In addition, we have designed and synthesized the first cell-permeable inhibitor of ecHinT and demonstrated that the wild-type E. coli treated with the inhibitor exhibited the same phenotype observed for the hinT knock-out strain. These results reveal that the catalytic activity and structure of ecHinT is essential for DadA function and therefore alanine metabolism in E. coli. Moreover, they provide the first biochemical evidence linking the catalytic activity of this ubiquitous protein to the biological function of Hints in Escherichia coli