355 research outputs found
Coisotropic deformations of associative algebras and dispersionless integrable hierarchies
The paper is an inquiry of the algebraic foundations of the theory of
dispersionless integrable hierarchies, like the dispersionless KP and modified
KP hierarchies and the universal Whitham's hierarchy of genus zero. It stands
out for the idea of interpreting these hierarchies as equations of coisotropic
deformations for the structure constants of certain associative algebras. It
discusses the link between the structure constants and the Hirota's tau
function, and shows that the dispersionless Hirota's bilinear equations are,
within this approach, a way of writing the associativity conditions for the
structure constants in terms of the tau function. It also suggests a simple
interpretation of the algebro-geometric construction of the universal Whitham's
equations of genus zero due to Krichever.Comment: minor misprints correcte
Gut-Brain Interactions: Implications for a Role of the Gut Microbiota in the Treatment and Prognosis of Anorexia Nervosa and Comparison to Type I Diabetes
Anorexia nervosa has poor prognosis and treatment outcomes and is influenced by genetic, metabolic, and psychological factors. Gut microbes interact with gut physiology to influence metabolism and neurobiology, although potential therapeutic benefits remain unknown. Type 1 diabetes is linked to anorexia nervosa through energy dysregulation, which in both disease states is related to the gut microbiota, disordered eating, and genetics
Eating Disorders and the Intestinal Microbiota: Mechanisms of Energy Homeostasis and Behavioral Influence
Purpose of Review: We reviewed and evaluated recently published scientific studies that explored the role of the intestinal microbiota in eating disorders. Recent Findings: Studies have demonstrated that the intestinal microbiota is a contributing factor to both host energy homeostasis and behaviorâtwo traits commonly disrupted in patients with eating disorders. To date, intestinal microbiota research in eating disorders has focused solely on anorexia nervosa (AN). Initial studies have reported an atypical intestinal microbial composition in patients with AN compared to healthy controls. However, the impact of these AN-associated microbial communities on host metabolism and behavior remains unknown. Summary: The intriguing pattern of findings in patients with AN encourages further investigation of the intestinal microbiota in eating disorders. Elucidating the specific role(s) of these microbial communities may yield novel ideas for augmenting current clinical therapies to promote weight gain, decrease gastrointestinal distress, and even reduce psychological symptomatology
Daily Changes in Composition and Diversity of the Intestinal Microbiota in Patients with Anorexia Nervosa: A Series of Three Cases
Anorexia nervosa, a severe psychiatric illness, is associated with an intestinal microbial dysbiosis. Individual microbial signatures dominate in healthy samples, even over time and under controlled conditions, but whether microbial markers of the disorder overcome inter-individual variation during the acute stage of illness or renourishment is unknown. We characterized daily changes in the intestinal microbiota in three acutely ill patients with anorexia nervosa over the entire course of hospital-based renourishment and found significant, patient-specific changes in microbial composition and diversity. This preliminary case series suggests that even in a state of pathology, individual microbial signatures persist in accounting for the majority of intestinal microbial variation
Thinking about growth : a cognitive mapping approach to understanding small business development
School of Managemen
Modified gravity in a viscous and non-isotropic background
We study the dynamical evolution of an model of gravity in a viscous
and anisotropic background which is given by a Bianchi type-I model of the
Universe. We find viable forms of gravity in which one is exactly the
Einsteinian model of gravity with a cosmological constant and other two are
power law models. We show that these two power law models are stable
with a suitable choice of parameters. We also examine three potentials which
exhibit the potential effect of models in the context of scalar tensor
theory. By solving different aspects of the model and finding the physical
quantities in the Jordan frame, we show that the equation of state parameter
satisfy the dominant energy condition. At last we show that the two power law
models behave like quintessence model at late times and also the shear
coefficient viscosity tends to zero at late times.Comment: 7 pages, 2 figure
The Binge Eating Genetics Initiative (BEGIN): Study protocol
Background: The Binge Eating Genetics Initiative (BEGIN) is a multipronged investigation examining the interplay of genomic, gut microbiota, and behavioral factors in bulimia nervosa and binge-eating disorder. Methods: 1000 individuals who meet current diagnostic criteria for bulimia nervosa or binge-eating disorder are being recruited to collect saliva samples for genotyping, fecal sampling for microbiota characterization, and recording of 30 days of passive data and behavioral phenotyping related to eating disorders using the app Recovery Record adapted for the Apple Watch. Discussion: BEGIN examines the interplay of genomic, gut microbiota, and behavioral factors to explore etiology and develop predictors of risk, course of illness, and response to treatment in bulimia nervosa and binge-eating disorder. We will optimize the richness and longitudinal structure of deep passive and active phenotypic data to lay the foundation for a personalized precision medicine approach enabling just-in-time interventions that will allow individuals to disrupt eating disorder behaviors in real time before they occur. Trial registration: The ClinicalTrials.gov identifier is NCT04162574. November 14, 2019, Retrospectively Registered
How does the electromagnetic field couple to gravity, in particular to metric, nonmetricity, torsion, and curvature?
The coupling of the electromagnetic field to gravity is an age-old problem.
Presently, there is a resurgence of interest in it, mainly for two reasons: (i)
Experimental investigations are under way with ever increasing precision, be it
in the laboratory or by observing outer space. (ii) One desires to test out
alternatives to Einstein's gravitational theory, in particular those of a
gauge-theoretical nature, like Einstein-Cartan theory or metric-affine gravity.
A clean discussion requires a reflection on the foundations of electrodynamics.
If one bases electrodynamics on the conservation laws of electric charge and
magnetic flux, one finds Maxwell's equations expressed in terms of the
excitation H=(D,H) and the field strength F=(E,B) without any intervention of
the metric or the linear connection of spacetime. In other words, there is
still no coupling to gravity. Only the constitutive law H= functional(F)
mediates such a coupling. We discuss the different ways of how metric,
nonmetricity, torsion, and curvature can come into play here. Along the way, we
touch on non-local laws (Mashhoon), non-linear ones (Born-Infeld,
Heisenberg-Euler, Plebanski), linear ones, including the Abelian axion (Ni),
and find a method for deriving the metric from linear electrodynamics (Toupin,
Schoenberg). Finally, we discuss possible non-minimal coupling schemes.Comment: Latex2e, 26 pages. Contribution to "Testing Relativistic Gravity in
Space: Gyroscopes, Clocks, Interferometers ...", Proceedings of the 220th
Heraeus-Seminar, 22 - 27 August 1999 in Bad Honnef, C. Laemmerzahl et al.
(eds.). Springer, Berlin (2000) to be published (Revised version uses
Springer Latex macros; Sec. 6 substantially rewritten; appendices removed;
the list of references updated
Associations of Dietary Intake with the Intestinal Microbiota and Short-Chain Fatty Acids Among Young Adults with Type 1 Diabetes and Overweight or Obesity
Background: Diet, a key component of type 1 diabetes (T1D) management, modulates the intestinal microbiota and its metabolically active byproductsâincluding SCFAâthrough fermentation of dietary carbohydrates such as fiber. However, the dietâmicrobiome relationship remains largely unexplored in longstanding T1D. Objectives: We evaluated whether increased carbohydrate intake, including fiber, is associated with increased SCFA-producing gut microbes, SCFA, and intestinal microbial diversity among young adults with longstanding T1D and overweight or obesity. Methods: Young adult men and women with T1D for â„1 y, aged 19â30 y, and BMI of 27.0â39.9 kg/m2 at baseline provided stool samples at baseline and 3, 6, and 9 mo of a randomized dietary weight loss trial. Diet was assessed by 1â2 24-h recalls. The abundance of SCFA-producing microbes was measured using 16S rRNA gene sequencing. GC-MS measured fecal SCFA (acetate, butyrate, propionate, and total) concentrations. Adjusted and Bonferroni-corrected generalized estimating equations modeled associations of dietary fiber (total, soluble, and pectins) and carbohydrate (available carbohydrate, and fructose) with microbiome-related outcomes. Primary analyses were restricted to data collected before COVID-19 interruptions. Results: Fiber (total and soluble) and carbohydrates (available and fructose) were positively associated with total SCFA and acetate concentrations (n = 40 participants, 52 visits). Each 10 g/d of total and soluble fiber intake was associated with an additional 8.8 ÎŒmol/g (95% CI: 4.5, 12.8 ÎŒmol/g; P = 0.006) and 24.0 ÎŒmol/g (95% CI: 12.9, 35.1 ÎŒmol/g; P = 0.003) of fecal acetate, respectively. Available carbohydrate intake was positively associated with SCFA producers Roseburia and Ruminococcus gnavus. All diet variables except pectin were inversely associated with normalized abundance of Bacteroides and Alistipes. Fructose was inversely associated with Akkermansia abundance. Conclusions: In young adults with longstanding T1D, fiber and carbohydrate intake were associated positively with fecal SCFA but had variable associations with SCFA-producing gut microbes. Controlled feeding studies should determine whether gut microbes and SCFA can be directly manipulated in T1D
Sequence variant analysis reveals poor correlations in microbial taxonomic abundance between humans and mice after gnotobiotic transfer
Transplanting human gut microbiotas into germ-free (GF) mice is a popular approach to disentangle cause-and-effect relationships between enteric microbes and disease. Algorithm development has enabled sequence variant (SV) identification from 16S rRNA gene sequence data. SV analyses can identify which donor taxa colonize recipient GF mice, and how SV abundance in humans is replicated in these mice. Fecal microbiotas from 8 human subjects were used to generate 77 slurries, which were transplanted into 153 GF mice. Strong correlations between fecal and slurry microbial communities were observed; however, only 42.15 ± 9.95% of SVs successfully transferred from the donor to the corresponding recipient mouse. Firmicutes had a particularly low transfer rate and SV abundance was poorly correlated between donor and recipient pairs. Our study confirms human fecal microbiotas colonize formerly GF mice, but the engrafted community only partially resembles the input human communities. Our findings emphasize the importance of reporting a standardized transfer rate and merit the exploration of other animal models or in silico tools to understand the relationships between human gut microbiotas and disease
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