Close range mini Uavs photogrammetry for architecture survey

The survey of historical façades contains several bottlenecks, mainly related to the geometrical structure, the decorative framework, the presence of natural or artificial obstacles, the environment limitations. Urban context presents additional restrictions, binding by ground acquisition activity and leading to building data loss. The integration of TLS and close-range photogrammetry allows to go over such stuff, not overcoming the shadows effect due to the ground point of view. In the last year the massive use of UAVs in survey activity has permitted to enlarge survey capabilities, reaching a deeper knowledge in the architecture analysis. In the meanwhile, several behaviour rules have been introduced in different countries, regulating the UAVs use in different field, strongly restricting their application in urban areas. Recently very small and light platforms have been presented, which can partially overcome these rules restrictions, opening to very interesting future scenarios. This article presents the application of one of these very small RPAS (less than 300 g), equipped with a low-cost camera, in a close range photogrammetric survey of an historical building façade in Bologna (Italy). The suggested analysis tries to point out the system accuracy and details acquisition capacity. The final aim of the paper is to validate the application of this new platform in an architectonic survey pipeline, widening the future application of close-range photogrammetry in the architecture acquisition process

Il Disegno per la ricostruzione di una storia. Il restauro virtuale del Monumento a Costanzo Ciano a Montenero di Livorno

In un eterogeneo contesto storico-culturale, talvolta animato da umano pregiudizio, il porre l’attenzione su uno degli elementi simbolici più rappresentativi del Ventennio, potrebbe configurarsi forse come un atteggiamento provocatorio, ma prescindendo da considerazioni che esulano dagli intenti degli scriventi, il Monumento a Costanzo Ciano, riteniamo rappresenti un tanto interessante quanto emblematico episodio artistico di quel preciso periodo culturale. L’interesse non si limita alla sola valenza delle “tessere”, ancor oggi diffuse sul territorio nazionale, di un mosaico rimasto incompiuto, ma anche nelle ingenti ed interessanti testimonianze documentali di progetto. Elementi la cui lettura interpretativa è stata condotta mediante le metodologie di studio, proprie della Disciplina del Disegno, e più in particolare inerenti il campo del ‘restauro virtuale’, da intendere in questo caso come unico possibile ed efficace strumento di recupero di compiutezza formale, oltre che di comunicazione e divulgazione.The study about the Monument devoted to Costanzo Ciano, one of the most symbolic elements of the fascist period, could be considered provocative in such an historical and cultural period signed by human prejudice, but going beyond the writers’ intentions, the aim of this research is to investigate this interesting and emblematic artistic episode of that cultural period. The interest is not only limited to the value of the lost ‘pieces’ belonged to the unfinished mosaic and still scattered on the national territory, but it’s also related to the great and interesting documentary evidences associated to the project. Methodologies framed in the Representation Discipline have been applied for document interpretation, with attention to the ‘virtual restoration’ as the only possible and effective methodology both to recover its formal completeness, as well as of communicate and divulgate it

Il Disegno per la ricostruzione di una storia. Il restauro virtuale del Monumento a Costanzo Ciano a Montenero di Livorno

The study about the Monument devoted to Costanzo Ciano, one of the most symbolic elements of the fascist period, could be considered provocative in such an historical and cultural period signed by human prejudice, but going beyond the writers’ intentions, the aim of this research is to investigate this interesting and emblematic artistic episode of that cultural period. The interest is not only limited to the value of the lost ‘pieces’ belonged to the unfinished mosaic and still scattered on the national territory, but it’s also related to the great and interesting documentary evidences associated to the project. Methodologies framed in the Representation Discipline have been applied for document interpretation, with attention to the ‘virtual restoration’ as the only possible and effective methodology both to recover its formal completeness, as well as of communicate and divulgate it

Does the molecular and metabolic profile of human granulosa cells correlate with oocyte fate? New insights by Fourier transform infrared microspectroscopy analysis

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Induced sputum is a reproducible method to assess airway inflammation in asthma.

To evaluate the reproducibility of induced sputum analysis, and to estimate the sample size required to obtained reliable results, sputum was induced by hypertonic saline inhalation in 29 asthmatic subjects on two different days. The whole sample method was used for analysis, and inflammatory cells were counted on cytospin slides. Reproducibility, expressed by intra-class correlation coefficients, was good for macrophages (+0.80), neutrophils (+0.85), and eosinophils (+0.87), but not for lymphocytes (+0.15). Detectable differences were 5.5% for macrophages, 0.6% for lymphocytes, 5.2% for neutrophils, and 3.0% for eosinophils. We conclude that analysis of induced sputum is a reproducible method to study airway inflammation in asthma. Sample sizes greater than ours give little improvement in the detectable difference of eosinophil percentages

Psychobiological evidence of the stress resilience fostering properties of a cosmetic routine

Everyday life psychosocial stressors contribute to poor health and disease vulnerabilty. Means alternative to pharmacotherapy that are able to foster stress resilience are more and more under the magnifying glass of biomedical research. The aim of this study was to test stress resilience fostering properties of the self-administration of a cosmetic product enriched with essential oils. On day 0, fourty women, 25-50 years old, self-administered both the enriched cosmetic product (ECP) and a placebo one (PCP). Then, women were randomized for daily self-administration (from day 1 to 28) of either ECP

Induced sputum is a reproducible method to assess airway inflammation in asthma

TO evaluate the reproducibility of induced sputum analysis, and to estimate the sample size required to obtained reliable results, sputum was induced by hypertonic saline inhalation in 29 asthmatic subjects on two different days. The whole sample method was used for analysis, and inflammatory cells were counted on cytospin slides. Reproducibility, expressed by intra-class correlation coefficients, was good for macrophages (+0.80), neutrophils (+0.85), and eosinophils (+0.87), but not for lymphocytes (+0.15). Detectable differences were 5.5% for macrophages, 0.6% for lymphocytes, 5.2% for neutrophils, and 3.0% for eosinophils. We conclude that analysis of induced sputum is a reproducible method to study airway inflammation in asthma. Sample sizes greater than ours give little improvement in the detectable difference of eosinophil percentages

Large scale multifactorial likelihood quantitative analysis of BRCA1 and BRCA2 variants: An ENIGMA resource to support clinical variant classification

The multifactorial likelihood analysis method has demonstrated utility for quantitative assessment of variant pathogenicity for multiple cancer syndrome genes. Independent data types currently incorporated in the model for assessing BRCA1 and BRCA2 variants include clinically calibrated prior probability of pathogenicity based on variant location and bioinformatic prediction of variant effect, co-segregation, family cancer history profile, co-occurrence with a pathogenic variant in the same gene, breast tumor pathology, and case-control information. Research and clinical data for multifactorial likelihood analysis were collated for 1,395 BRCA1/2 predominantly intronic and missense variants, enabling classification based on posterior probability of pathogenicity for 734 variants: 447 variants were classified as (likely) benign, and 94 as (likely) pathogenic; and 248 classifications were new or considerably altered relative to ClinVar submissions. Classifications were compared with information not yet included in the likelihood model, and evidence strengths aligned to those recommended for ACMG/AMP classification codes. Altered mRNA splicing or function relative to known nonpathogenic variant controls were moderately to strongly predictive of variant pathogenicity. Variant absence in population datasets provided supporting evidence for variant pathogenicity. These findings have direct relevance for BRCA1 and BRCA2 variant evaluation, and justify the need for gene-specific calibration of evidence types used for variant classification

Search for new particles in events with energetic jets and large missing transverse momentum in proton-proton collisions at root s=13 TeV

A search is presented for new particles produced at the LHC in proton-proton collisions at root s = 13 TeV, using events with energetic jets and large missing transverse momentum. The analysis is based on a data sample corresponding to an integrated luminosity of 101 fb(-1), collected in 2017-2018 with the CMS detector. Machine learning techniques are used to define separate categories for events with narrow jets from initial-state radiation and events with large-radius jets consistent with a hadronic decay of a W or Z boson. A statistical combination is made with an earlier search based on a data sample of 36 fb(-1), collected in 2016. No significant excess of events is observed with respect to the standard model background expectation determined from control samples in data. The results are interpreted in terms of limits on the branching fraction of an invisible decay of the Higgs boson, as well as constraints on simplified models of dark matter, on first-generation scalar leptoquarks decaying to quarks and neutrinos, and on models with large extra dimensions. Several of the new limits, specifically for spin-1 dark matter mediators, pseudoscalar mediators, colored mediators, and leptoquarks, are the most restrictive to date.Peer reviewe