Dynamic vs static scaling: an existence result

International audienceThe relation between static and dynamic control Lyapunov functions scaling is discussed. It is shown that, under some technical assumptions, stabilizability by means of static scaling implies stabilizability by means of dynamic scaling. A motivating example and a worked out design example complement the theoretical part

PI3kinases in diabetes mellitus and its related complications

Recent studies have shown that phosphoinositide 3-kinases (PI3Ks) have become the target of many pharmacological treatments, both in clinical trials and in clinical practice. PI3Ks play an important role in glucose regulation, and this suggests their possible involvement in the onset of diabetes mellitus. In this review, we gather our knowledge regarding the effects of PI3K isoforms on glucose regulation in several organs and on the most clinically-relevant complications of diabetes mellitus, such as cardiomyopathy, vasculopathy, nephropathy, and neurological disease. For instance, PI3K α has been proven to be protective against diabetes-induced heart failure, while PI3K γ inhibition is protective against the disease onset. In vessels, PI3K γ can generate oxidative stress, while PI3K β inhibition is anti-thrombotic. Finally, we describe the role of PI3Ks in Alzheimer’s disease and ADHD, discussing the relevance for diabetic patients. Given the high prevalence of diabetes mellitus, the multiple effects here described should be taken into account for the development and validation of drugs acting on PI3Ks

Celiac vagus nerve stimulation recapitulates angiotensin II-induced splenic noradrenergic activation, driving egress of CD8 effector cells

Angiotensin II (AngII) is a peptide hormone that affects the cardiovascular system, not only through typical effects on the vasculature, kidneys, and heart, but also through less understood roles mediated by the brain and the immune system. Here, we address the hard-wired neural connections within the autonomic nervous system that modulate splenic immunity. Chronic AngII infusion triggers burst firing of the vagus nerve celiac efferent, an effect correlated with noradrenergic activation in the spleen and T cell egress. Bioelectronic stimulation of the celiac vagus nerve, in the absence of other challenges and independently from afferent signals to the brain, evokes the noradrenergic splenic pathway to promote release of a growth factor mediating neuroimmune crosstalk, placental growth factor (PlGF), and egress of CD8 effector T cells. Our findings also indicate that the neuroimmune interface mediated by PlGF and necessary for transducing the neural signal into an effective immune response is dependent on α-adrenergic receptor signaling

Flow over the Mid Adriatic Pit

The influence of the Mid Adriatic Pit (MAP) on the general circulation of the Adriatic is explored through numerical simulations. The numerical code used is the DieCAST model specifically modified for application to the Adriatic Sea. A ten-year simulation is performed and the ability of the model to capture important features of the Adriatic circulation is demonstrated. A series of numerical experiments on the importance of the MAP on the general circulation is performed. It is demonstrated that the current over the northern flank of the MAP, which flows from the Croatian toward the Italian coast, is primarily a topographic current and that such a current would reverse direction if the gradient of the bathymetry were reversed

Flow over the Mid Adriatic Pit

The influence of the Mid Adriatic Pit (MAP) on the general circulation of the Adriatic is explored through numerical simulations. The numerical code used is the DieCAST model specifically modified for application to the Adriatic Sea. A ten-year simulation is performed and the ability of the model to capture important features of the Adriatic circulation is demonstrated. A series of numerical experiments on the importance of the MAP on the general circulation is performed. It is demonstrated that the current over the northern flank of the MAP, which flows from the Croatian toward the Italian coast, is primarily a topographic current and that such a current would reverse direction if the gradient of the bathymetry were reversed

Time Pressure and the Development of Integrative Agreements in Bilateral Negotiations

A laboratory experiment examined the effects of time pressure on the process and outcome of integrative bargaining. Time pressure was operationalized in terms of the amount of time available to negotiate. As hypothesized, high time pressure produced nonagreements and poor negotiation outcomes only when negotiators adopted an individualistic orientation; when negotiators adopted a cooperative orientation, they achieved high outcomes regardless of time pressure. In combination with an individualistic orientation, time pressure produced greater competitiveness, firm negotiator aspirations, and reduced information exchange. In combination with a cooperative orientation, time pressure produced greater cooperativeness and lower negotiator aspirations. The main findings were seen as consistent with Pruitt’s strategic-choice model of negotiation