Digital nerve injuries: Epidemiology, results, costs, and impact on daily life.

Epidemiology, results of treatment, impact on activity of daily living (ADL), and costs for treatment of digital nerve injuries have not been considered consistently. Case notes of patients of 0-99 years of age living in Malmö municipality, Sweden, who presented with a digital nerve injury and were referred to the Department of Hand Surgery in 1995-2005 were analysed retrospectively. The incidence was 6.2/100 000 inhabitants and year. Most commonly men (75%; median age 29 years) were injured. Isolated nerve injuries and concomitant tendon injuries were equally common. The direct costs (hospital stay, operation, outpatient visits, visits to a nurse and/or a hand therapist) for a concomitant tendon injury was almost double compared with an isolated digital nerve injury (6136 EUR [range, 744-29 689 EUR] vs 2653 EUR [range, 468-6949 EUR]). More than 50% of the patients who worked were injured at work and 79% lost time from work (median 59 days [range 3-337]). Permanent nerve dysfunction for the individual patient with ADL problems and subjective complaints of fumbleness, cold sensitivity, and pain occur in the patients despite surgery. It is concluded that digital nerve injuries, often considered as a minor injury and that affect young people at productive age, cause costs, and disability. Focus should be directed against prevention of the injury and to improve nerve regeneration from different aspects

Polar Localization of Virulence-Related Esx-1 Secretion in Mycobacteria

The Esx-1 (type VII) secretion system is critical for virulence of both Mycobacterium tuberculosis and Mycobacterium marinum, and is highly conserved between the two species. Despite its importance, there has been no direct visualization of Esx-1 secretion until now. In M. marinum, we show that secretion of Mh3864, a novel Esx-1 substrate that remains partially cell wall–associated after translocation, occurred in polar regions, indicating that Esx-1 secretion takes place in these regions. Analysis of Esx-1 secretion in infected host cells suggested that Esx-1 activity is similarly localized in vivo. A core component of the Esx-1 apparatus, Mh3870, also localized to bacterial poles, showing a preference for new poles with active cell wall peptidoglycan (PGN) synthesis. This work demonstrates that the Esx-1 secretion machine localizes to, and is active at, the bacterial poles. Thus, virulence-related protein secretion is localized in mycobacteria, suggesting new potential therapeutic targets, which are urgently needed

Lithium in the Upper Centaurus Lupus and Lower Centaurus Crux Subgroups of Scorpius-Centaurus

We utilize spectroscopically derived model atmosphere parameters and the \ion{Li}{1} $\lambda6104$ subordinate line and the $\lambda6708$ doublet to derive lithium abundances for 12 members of the Upper-Centaurus Lupus (UCL) and Lower-Centaurus Crux (LCC) subgroups of the Scorpius Centaurus OB Association. The results indicate any intrinsic Li scatter in our 0.9-1.4 $M_{\odot}$ stars is limited to ${\sim}0.15$ dex, consistent with the lack of dispersion in ${\ge}1.0$ $M_{\odot}$ stars in the 100 Myr Pleiades and 30-50 Myr IC 2391 and 2602 clusters. Both ab initio uncertainty estimates and the derived abundances themselves indicate that the $\lambda$6104 line yields abundances with equivalent or less scatter than is found from the $\lambda$6708 doublet as a result of lower uncertainties for the subordinate feature, a result of low sensitivity to broadening in the subordinate feature. Because NLTE corrections are less susceptible to changes in surface gravity and/or metallicity for the 6104 {\AA} line, the subordinate Li feature is preferred for deriving lithium abundances in young Li-rich stellar association stars with $T_{\rm eff}{\ge}5200$ K.Comment: Accepted for publication in Astronomical Journal (abstract shortened for astro-ph submission

V474 Car: A Rare Halo RS CVn Binary in Retrograde Galactic Orbit

We report the discovery that the star V474 Car is an extremely active, high velocity halo RS CVn system. The star was originally identified as a possible pre-main sequence star in Carina, given its enhanced stellar activity, rapid rotation (10.3 days), enhanced Li, and absolute magnitude that places it above the main sequence. However, its extreme radial velocity (264 km s$^{-1}$) suggested that this system was unlike any previously known pre-MS system. Our detailed spectroscopic analysis of echelle spectra taken with the CTIO 4-m finds that V474 Car is both a spectroscopic binary with orbital period similar to the photometric rotation period, and metal poor ([Fe/H] $\simeq -$0.99). The star's Galactic orbit is extremely eccentric (e $\simeq$ 0.93) with perigalacticon of only $\sim$0.3 kpc of the Galactic center - and its eccentricity and smallness of its perigalacticon are only surpassed by $\sim$0.05%, of local F/G-type field stars. The observed characteristics are consistent with V474 Car being a high velocity, metal poor, tidally-locked chromospherically active binary (CAB), i.e.\ a halo RS CVn binary, and one of only a few such specimens known.Comment: Accepted to Astronomical Journa

Enhanced Yields in Organic Arable Crop Production by Eco-Functional Intensification using Intercropping

Organic agriculture faces challenges to enhance food production per unit area and simultaneously reduce the environmental and climate impacts, e.g. nitrate leaching per unit area and greenhouse gas (GHG) emissions per unit mass produced. Eco-functional intensification is suggested as a means to reach these objectives. Eco-functional intensification involves activating more knowledge and refocusing the importance of ecosystem services in agriculture. Organic farmers manage agrobiodiversity by crop rotation (diversification in time). However, sole cropping (SC) of genetically identical plants in organic agriculture may limit resource use efficiency and yield per unit area. Intercropping (IC) of annual grain species, cultivar mixes, perennial grains, or forage species and forestry and annual crops (agroforestry) are examples of spatial crop diversification. Intercropping is based on eco-functional intensification and may enhance production by complementarity in resource use in time and space. Intercropping is based on the ecological principles of competition, facilitation and complementarity, which often increases the efficiency in acquisition and use of resources such as light, water and nutrients compared to sole crops, especially in low-input systems. Here we show that IC of cereals and grain legumes in European arable organic farming systems is an efficient tool for enhancing total grain yields compared to their respective sole crops. Simultaneously, we display how intercropping of cereals and legumes can be used as an efficient tool for weed management and to enhance product quality (i.e. cereal grain protein concentration). We discuss how intercropping contributes to efficient use of soil N sources and minimizes losses of N by nitrate leaching via Ecological Precision Farming. It is concluded that intercropping has a strong potential to increase yield and hereby reduce global climate impacts such as GHG/kg grain. Finally, we discuss likely barriers and lock-in effects for increased use of intercropping in organic farming and suggest a roadmap for innovation and implementation of IC strategies in organic agriculture

Grain legume-cereal intercropping enhances the use of soil-derived and biologically fixed nitrogen in temperate agroecosystems: a meta-analysis

Grain legumes are known for their benefits to deliver ecosystem services on provisioning of protein-rich food and feed, reducing greenhouse gas emissions through the symbiotic nitrogen fixation function and diversification of cropping systems. Intercropping is an agroecological practice in which two or more crop species are grown simultaneously in the same field, thereby maximizing the use of resources to enhance yields in low input systemsand the resilience of cropping systems. We quantified the effect of grain legume-cereal intercropping on the useof N resources in temperate agroecosystems, focusing on dinitrogen (N2) fixation and soil-derived nitrogenacquisition using a meta-analysis of 29 field-scale studies. We estimated and compared effects of different intercrop compositions (proportion of each species in the intercrops), fertilization rates, crop species, soil properties, and other management practices on the symbiotic N2 fixation and the acquisition of soil-derived nitrogenby the cereals and grain legumes. The proportion of N derived from N2 fixation was on average 14 % (95 % CI =[11, 16]) higher in intercropped grain legumes (76 %) compared to legume sole crops (66 %). On the other hand,intercropping reduced the amount of N2 fixed (kg ha−1) by about 15 %, when N2 fixation in inter- and solecropped legumes was expressed at equivalent density by compensating for the sown legume proportion in intercrops relative to their sole crop sowing rate. The results were mainly influenced by the intercrop composition,legumes species and the method used to quantify N2 fixation. Soil-derived nitrogen acquisition in intercroppedgrain legumes was significantly reduced (−47 %, 95 % CI = [−56, −36]) compared to sole crop legumes,expressed at equivalent density, while the soil N acquired by intercropped cereals was much higher (+61 %, 95% CI = [24, 108]) than in sole crop cereals. Total soil N acquisition (legume + cereal) was significantly higherin intercrops than in legume sole crops (+25 %, 95 % CI = [1, 54]), while there was no significant differencebetween intercrops and cereal sole crops. The meta-analysis confirms and highlights that intercropping consistently stimulates complementary N use between legumes and cereals by increasing N2 fixation by grain legumes and increasing soil N acquisition in cereals. Based on the results of this analysis it would be suggested thatcropping systems diversification via intercropping can be used for simultaneous production of both cereals andgrain legumes, while increasing the use of N-sources and reducing external inputs of N fertilizers, thereby enhancing the sustainability of agriculture