A Sargassum fluitans Borgesen Ethanol Extract Exhibits a Hepatoprotective Effect In Vivo in Acute and Chronic Liver Damage Models

One of the leading causes of death worldwide, cirrhosis, is a liver condition characterized by chronic necrosis, inflammation, and fibrosis. Hepatoprotective compounds, such as antioxidants, can prevent fibrosis. Macroalgae (seaweed) contain high amounts of antioxidant compounds and are plentiful; indeed, species such as Sargassum fluitans Borgesen (Phaeophyceae) carpet many beaches in the Caribbean Basin. An in vivo assay was done evaluating the possible hepatoprotective effect of a Sargassum fluitans ethanol extract. Two murine liver damage models were employed: acetaminophen (APAP) in Balb/c mice to induce acute damage; carbon tetrachloride (CCl4) in Wistar rats to induce chronic damage. Serum liver enzyme levels and relative liver weight were measured, and histopathological and immunohistochemical analyses of liver tissue sections were done. Both APAP and CCl4 significantly raised serum enzyme marker enzymes. Administration of 50 mg/kg S. Fluitans ethanol extract reduced this APAP- and CCl4-induced elevation to normal levels. This effect was corroborated by the extract’s inhibition of inflammation and fibrosis in liver tissue observed in the histopathological analysis. The analyzed S. fluitans ethanol extract exhibited an in vivo hepatoprotective effect in acute and chronic liver injury models

Use of a rotating biological contactor system for treatment of septic tank effluents.

Although septic tanks is the most common wastewater treatment device used in the State of Yucatan, Mexico, it is a deficient purification process and therefore further treatment is needed. This work presents the results from a pilot-scale rotating biological contactor (RBC) process used to treat septic tank effluent. The RBC was operated with three organic loading rates (5.2, 15.9 and 17.2 g BOD5/m2·d) and two rotation velocities (15 and 30 rpm). COD, BOD5, TKN and NH3-N removal efficiencies were measured and a factorial analysis was carried out to determine the best operating conditions. The organic loading rate was shown to be the variable that had the greatest effect on the process, with lower loads and better efficiency (roughly 90% for COD and BOD5). Rotation velocity was significant for the removal nitrogenous matter. The most efficient combination was found to be 5.2 g DBO5/m2·d at 30 rpm, which is equivalent to a tangential velocity of 16.49 m/min