Formation and Disruption of Cosmological Low Mass Objects

We investigate the evolution of cosmological low mass (low virial temperature) objects and the formation of the first luminous objects. First, the `cooling diagram' for low mass objects is shown. We assess the cooling rate taking into account the contribution of H_2, which is not in chemical equilibrium generally, with a simple argument of time scales. The reaction rates and the cooling rate of H_2 are taken from the recent results by Galli & Palla (1998). Using this cooling diagram, we also estimate the formation condition of luminous objects taking into account the supernova (SN) disruption of virialized clouds. We find that the mass of the first luminous object is several times 10^7 solar mass, because smaller objects may be disrupted by the SNe before they become luminous. Metal pollution of low mass (Ly-alpha) clouds also discussed. The resultant metallicity of the clouds is about 1/1000 of the solar metallicity.Comment: 11 pages, 2 figures, To appear in ApJ

Is there Evidence for a Hubble bubble? The Nature of Type Ia Supernova Colors and Dust in External Galaxies

We examine recent evidence from the luminosity-redshift relation of Type Ia Supernovae (SNe Ia) for the $\sim 3 \sigma$ detection of a ``Hubble bubble'' -- a departure of the local value of the Hubble constant from its globally averaged value \citep{Jha:07}. By comparing the MLCS2k2 fits used in that study to the results from other light-curve fitters applied to the same data, we demonstrate that this is related to the interpretation of SN color excesses (after correction for a light-curve shape-color relation) and the presence of a color gradient across the local sample. If the slope of the linear relation ($\beta$) between SN color excess and luminosity is fit empirically, then the bubble disappears. If, on the other hand, the color excess arises purely from Milky Way-like dust, then SN data clearly favors a Hubble bubble. We demonstrate that SN data give $\beta \simeq 2$, instead of the $\beta \simeq 4$ one would expect from purely Milky-Way-like dust. This suggests that either SN intrinsic colors are more complicated than can be described with a single light-curve shape parameter, or that dust around SN is unusual. Disentangling these possibilities is both a challenge and an opportunity for large-survey SN Ia cosmology.Comment: Further information and data at http://qold.astro.utoronto.ca/conley/bubble/ Accepted for publication in ApJ

Formation of Primordial Protostars

The evolution of collapsing metal free protostellar clouds is investigated for various masses and initial conditions. We perform hydrodynamical calculations for spherically symmetric clouds taking account of radiative transfer of the molecular hydrogen lines and the continuum, as well as of chemistry of the molecular hydrogen. The collapse is found to proceed almost self-similarly like Larson-Penston similarity solution. In the course of the collapse, efficient three-body processes transform atomic hydrogen in an inner region of \sim 1 M_{\sun} entirely into molecular form. However, hydrogen in the outer part remains totally atomic although there is an intervening transitional layer of several solar masses, where hydrogen is in partially molecular form. No opaque transient core is formed although clouds become optically thick to H$_{2}$ collision-induced absorption continuum, since H$_{2}$ dissociation follows successively. When the central part of the cloud reaches stellar densities ($\sim 10^{-2} {\rm g cm^{-3}}$), a very small hydrostatic core (\sim 5 \times 10^{-3} M_{\sun}) is formed and subsequently grows in mass as the ambient gas accretes onto it. The mass accretion rate is estimated to be 3.7 \times 10^{-2} M_{\sun} {\rm yr^{-1}} (M_{\ast}/M_{\sun})^{-0.37}, where $M_{\ast}$ is instantaneous mass of the central core, by using a similarity solution which reproduces the evolution of the cloud before the core formation.Comment: 20 pages, 5 Postscript figures, uses AAS LaTe

Cosmic Renaissance: The First Sources of Light

I review recent progress in understanding the formation of the first stars and quasars. The initial conditions for their emergence are given by the now firmly established model of cosmological structure formation. Numerical simulations of the collapse and fragmentation of primordial gas indicate that the first stars formed at redshifts z ~ 20 - 30, and that they were predominantly very massive, with M_* > 100 M_sun. Important uncertainties, however, remain. Paramount among them is the accretion process, which builds up the final stellar mass by incorporating part of the diffuse, dust-free envelope into the central protostellar core. The first quasars, on the other hand, are predicted to have formed later on, at z ~ 10, in more massive dark matter halos, with total masses, ~ 10^8 M_sun, characteristic of dwarf galaxies.Comment: 16 pages, 7 figures, invited review, to appear in PASP, Feb. 200

Regulation of the human p21((waf1/cip1)) gene promoter via multiple binding sites for p53 and the vitamin D(3) receptor

The main regulator of the human tumor suppresser gene p21((waf1/cip1)) is the transcription factor p53, but more recently it has been suggested to be a primary anti-proliferative target for the nuclear receptor VDR in the presence of its ligand 1α,25-dihydroxyvitamin D(3) (1α,25(OH)(2)D(3)). To identify VDR responding regions, we analyzed 20 overlapping regions covering the first 7.1 kb of the p21((waf1/cip1)) promoter in MCF-7 human breast cancer cells using chromatin immuno-precipitation assays (ChIP) with antibodies against p53 and VDR. We confirmed two known p53 binding regions at approximate positions −1400 and −2300 and identified a novel site at position −4500. In addition, we found three VDR-associated promoter regions at positions −2300, −4500 and −6900, i.e. two regions showed binding for both p53 and VDR. In silico screening and in vitro binding assays using recombinant and in vitro translated proteins identified five p53 binding sites within the three p53-positive promoter regions and also five 1α,25(OH)(2)D(3) response elements within the three VDR-positive regions. Reporter gene assays confirmed the expected responsiveness of the respective promoter regions to the p53 inducer 5-fluorouracil and 1α,25(OH)(2)D(3). Moreover, re-ChIP assays confirmed the functionality of the three 1α,25(OH)(2)D(3)-reponsive promoter regions by monitoring simultaneous occupancy of VDR with the co-activator proteins CBP, SRC-1 and TRAP220. Taken together, we demonstrated that the human p21((waf1/cip1)) gene is a primary 1α,25(OH)(2)D(3)-responding gene with at least three VDR binding promoter regions, in two of which also p53 co-localizes

Virial mass in DGP brane cosmology

We study the virial mass discrepancy in the context of a DPG brane-world scenario and show that such a framework can offer viable explanations to account for the mass discrepancy problem. This is done by defining a geometrical mass $\mathcal{N}$ that we prove to be proportional to the virial mass. Estimating $\mathcal{N}$ using observational data, we show that it behaves linearly with $r$ and has a value of the order of $M_{200}$, pointing to a possible resolution of the virial mass discrepancy. We also obtain the radial velocity dispersion of galaxy clusters and show that it is compatible with the radial velocity dispersion profile of such clusters. This velocity dispersion profile can be used to differentiate various models predicting the virial mass.Comment: 12 pages, 1 figure, to appear in CQ