Transcriptomic Signature of Human Embryonic Thyroid Reveals Transition From Differentiation to Functional Maturation

The human thyroid gland acquires a differentiation program as early as weeks 3–4 of embryonic development. The onset of functional differentiation, which manifests by the appearance of colloid in thyroid follicles, takes place during gestation weeks 10–11. By 12–13 weeks functional differentiation is accomplished and the thyroid is capable of producing thyroid hormones although at a low level. During maturation, thyroid hormones yield increases and physiological mechanisms of thyroid hormone synthesis regulation are established. In the present work we traced the process of thyroid functional differentiation and maturation in the course of human development by performing transcriptomic analysis of human thyroids covering the period of gestation weeks 7–11 and comparing it to adult human thyroid. We obtained specific transcriptomic signatures of embryonic and adult human thyroids by comparing them to non-thyroid tissues from human embryos and adults. We defined a non-TSH (thyroid stimulating hormone) dependent transition from differentiation to maturation of thyroid. The study also sought to shed light on possible factors that could replace TSH, which is absent in this window of gestational age, to trigger transition to the emergence of thyroid function. We propose a list of possible genes that may also be involved in abnormalities in thyroid differentiation and/or maturation, hence leading to congenital hypothyroidism. To our knowledge, this study represent the first transcriptomic analysis of human embryonic thyroid and its comparison to adult thyroid

Profiles of gene expression in radio-induced and sporadic thyroid tumors and in experimental models

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Is there a gene expression signature in radio-induced, Chernobyl PTC?

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Identification, caractérisation et régulation de l'expression de récepteurs contrôlant les G-protéines: les récepteurs de la thyrotropine, de l'adénosine A2 et de la sérotonine 5-HT 1D

Doctorat en Sciencesinfo:eu-repo/semantics/nonPublishe

Gene expression profiling in human thyroid tumors

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Gene expression in PTC and contra-lateral tissues from patients exposed and not exposed to the Chernobyl fallout

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Gene expression in normal and tumor thyroid cells and tissues

2008 European Thyroid Association Harington-De Visscher prize lectureinfo:eu-repo/semantics/nonPublishe

Molecular profiling of thyroid neoplasms

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Profiles of gene expression in thyroid tumors and in model systems

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Profils d'expression génique dans les tumeurs thyroïdiennes humaines.

Our work aims at defining by microarray gene expression profiles in different thyroid tumors: hyperfunctioning autonomous adenomas, and sporadic and post-Chernobyl papillary cancers. Gene expression analysis in hyperfunctioning autonomous adenomas allowed us to identify genes involved in various physiological processes of the thyroid. Concerning papillary cancers, gene expression profiling in post-Chernobyl and sporadic papillary carcinomas could not identify a specific gene expression signature allowing to distinguish both tumors although such a signature exists for autonomous adenomas and carcinomas. This suggests that both cancers represent the same disease, and that there is unlikely to be a molecular signature for radiation-induced thyroid cancer.SCOPUS: ar.jinfo:eu-repo/semantics/publishe