The impact of shape uncertainty on aortic-valve pressure-drop computations: supplementary data files

This data-set represents data that was used in: The impact of shape uncertainty on aortic-valve pressure-drop computations. M.J.M.M. Hoeijmakers, W. Huberts, M.C.M. Rutten, F.N. van de Vosse, 2021. Int. J. Numer. Method. Biomed. Eng. This data-set includes:- Resampled segmentations of 74 aortic valves with no, mild, moderate, or severe aortic stenosis - Corresponding extruded (10R) and un-extruded (0.1R) surface meshes in .vtk format.- *_R0.1.txt: centerline points and normals.- *_R10.txt: centerline points and normals that where used to post-process the computational fluid dynamics results. Computed pressures along the centerline on these planes are written to this file as well. Authors are free to use and explore this data-set for research purposes. For instance these surface meshes can be used to generate volumetric meshes (not included) of the enclosed domain for the purpose of computing the flow field(s)

Data underlying the publication: Computationally guided in-vitro vascular growth model reveals causal link between flow oscillations and disorganized neotissue

This repository contains the data and scripts required to reproduce the subfigures of figure 2 of: van Haaften et al 2021 "Computationally guided in-vitro vascular growth model reveals causal link between flow oscillations and disorganized neotissue" related to the computational simulations. More specifically, this repository contains:1) Datasets to visualize the time-averaged wall shear stress (TAWSS), oscillatory shear index (OSI) and the strain (ε) in graft at the venous anastomosis in Paraview. 2) Scripts and data to produce histograms of the time-averaged wall shear stress (TAWSS), oscillatory shear index (OSI) and the strain (ε) in the graft at the venous anastomosis in MATLA

Data underlying the publication: Generation of synthetic aortic valve stenosis geometries for in silico trials

This data set contains the data to reproduce the figures from the manuscript: 'Generation of synthetic aortic valve stenosis geometries for in silico trials'.More specifically, the data set contains:1) Real cohort of aortic valve geometries on which the statistical shape model of this manuscript is based.2) Virtual cohorts with synthetic geometries, generated for this manuscript.3) Figure scripts and data needed to reproduce figures of the manuscript.See the README.txt file for more information about the folders and files in the data set

Supplementary material from "Initial scaffold thickness affects the emergence of a geometrical and mechanical equilibrium in engineered cardiovascular tissues"

In situ cardiovascular tissue-engineering can potentially address the shortcomings of the current replacement therapies, in particular, their inability to grow and remodel. In native tissues, it is widely accepted that physiological growth and remodelling occurs to maintain a homeostatic mechanical state to conserve its function, regardless of changes in the mechanical environment. A similar homeostatic state should be reached for tissue-engineered (TE) prostheses to ensure proper functioning. For in situ tissue-engineering approaches obtaining such a state greatly relies on the initial scaffold design parameters. In this study, it is investigated if the simple scaffold design parameter initial thickness, influences the emergence of a mechanical and geometrical equilibrium state in in vitro TE constructs, which resemble thin cardiovascular tissues such as heart valves and arteries. Towards this end, two sample groups with different initial thicknesses of myofibroblast-seeded polycarpolactone-bisurea constructs were cultured for three weeks under dynamic loading conditions, while tracking geometrical and mechanical changes temporally using non-destructive ultrasound imaging. A mechanical equilibrium was reached in both groups, although at different magnitudes of the investigated mechanical quantities. Interestingly, a geometrically stable state was only established in the thicker constructs, while the thinner construct’s length continuously increased. This demonstrates that reaching geometrical and mechanical stability in TE constructs is highly dependent on functional scaffold design

RoA: visual analytics support for deconfounded causal inference in observational studies

Rod of Asclepius (RoA) is a proof-of-concept application that provides visual analytics support for deconfounded causal inference in observational studies. For convenience, a virtual appliance file is made available via DropBox that can be imported into software like VirtualBox. The file includes a pre-installed version of RoA inside a virtual machine running a Linux desktop. The virtual appliance can be downloaded below by clicking on the filename RoA.ova. See the Readme.txt for further instructions. Paper: https://doi.org/10.52933/jdssv.v4i3.72 Github: https://github.com/RodofAsclepius/Ro

ValveValid

The ValveValid dataset provides a comprehensive set of measurements for the aortic valve. This document outlines the structure of the dataset, how the data was acquired, and guidelines for effective use. This dataset aims to support research and development in the field of cardiac health by providing detailed geometric data on aortic valves. The ValveValid dataset contains measurement sizes (in millimeters) of the aortic valve from 402 patients, divided into two groups based on valve type: Edwards Sapien 3 and Medtronic CoreValve Evolut R. The dataset is stored in an Excel file, comprising various measurements typical for analyzing the aortic valve geometry

Intrauterine resuscitation during the second stage of term labour by maternal hyperoxygenation versus conventional care: study protocol for a randomised controlled trial (INTEREST O2)

Abstract Background Perinatal asphyxia is, even in developed countries, one the major causes of neonatal morbidity and mortality. Therefore, if foetal distress during labour is suspected, one should try to restore foetal oxygen levels or aim for immediate delivery. However, studies on the effect of intrauterine resuscitation during labour are scarce. We designed a randomised controlled trial to investigate the effect of maternal hyperoxygenation on the foetal condition. In this study, maternal hyperoxygenation is induced for the treatment of foetal distress during the second stage of term labour. Methods/design This study is a single-centre randomised controlled trial being performed in a tertiary hospital in The Netherlands. From among cases of a suboptimal or abnormal foetal heart rate pattern during the second stage of term labour, a total of 116 patients will be randomised to the control group, where normal care is provided, or to the intervention group, where before normal care 100% oxygen is supplied to the mother by a non-rebreathing mask until delivery. The primary outcome is change in foetal heart rate pattern. Secondary outcomes are Apgar score, mode of delivery, admission to the neonatal intensive care unit and maternal side effects. In addition, blood gas values and malondialdehyde are determined in umbilical cord blood. Discussion This study will be the first randomised controlled trial to investigate the effect of maternal hyperoxygenation for foetal distress during labour. This intervention should be recommended only as a treatment for intrapartum foetal distress, when improvement of the foetal condition is likely and outweighs maternal and neonatal side effects. Trial registration EudraCT, 2015-001654-15; registered on 3 April 2015. Dutch Trial Register, NTR5461; registered on 20 October 2015