Mechanical and physical characterization of papercrete as new eco-friendly construction material

The manufacturing of Portland cement is responsible for a big amount of energy and greenhouse gas (GHG) emission. Therefore, to date, it is imperative to find alternative materials to replace a major part of cement for sustainable concrete constructions. The present study forms a part of an on-going research project on the application of new cementitious matrices produced using different types of recycled materials. In particular, it focuses on the use of pulp and waste paper to partially replace Portland cement at varying percentages for producing a new lightweight mortar, frequently named papercrete. The development of this economical and eco-friendly material may permit of recycling a big amount of waste paper leading to lower housing costs with also ecological benefits. To this scope, an experimental campaign in the laboratory is carried out to characterize this new innovative material from a physical and mechanical point of view. The preliminary results of this on-going experimental campaign are illustrated and commented on in this paper. The obtained results confirm the possibility of applying this partially-recycled material as a possible alternative for strengthening existing panels of masonry

Association of a homozygous GCK missense mutation with mild diabetes

Background: Homozygous inactivating GCK mutations have been repeatedly reported to cause severe hyperglycemia, presenting as permanent neonatal diabetes mellitus (PNDM). Conversely, only two cases of GCK homozygous mutations causing mild hyperglycemia have been so far described. We here report a novel GCK mutation (c.1116G>C, p.E372D), in a family with one homozygous member showing mild hyperglycemia. Methods: GCK mutational screening was carried out by Sanger sequencing. Computational analyses to investigate pathogenicity and molecular dynamics (MD) were performed for GCK-E372D and for previously described homozygous mutations associated with mild (n = 2) or severe (n = 1) hyperglycemia, used as references. Results: Of four mildly hyperglycemic family-members, three were heterozygous and one, diagnosed in the adulthood, was homozygous for GCK-E372D. Two nondiabetic family members carried no mutations. Fasting glucose (p = 0.016) and HbA1c (p = 0.035) correlated with the number of mutated alleles (0–2). In-silico predicted pathogenicity was not correlated with the four mutations’ severity. At MD, GCK-E372D conferred protein structure flexibility intermediate between mild and severe GCK mutations. Conclusions: We present the third case of homozygous GCK mutations associated with mild hyperglycemia, rather than PNDM. Our in-silico analyses support previous evidences suggesting that protein stability plays a role in determining clinical severity of GCK mutations

Analysis and correction of the magnetic field effects in the Hybrid Photo-Detectors of the RICH2 Ring Imaging Cherenkov detector of LHCb

The Ring Imaging Cherenkov detectors of the LHCb experiment at the Large Hadron Collider at CERN are equipped with Hybrid Photo-Detectors. These vacuum photo-detectors are affected by the stray magnetic field of the LHCb magnet, which degrades their imaging properties. This effect increases the error on the Cherenkov angle measurement and would reduce the particle identification capabilities of LHCb. A system has been developed for the RICH2 Ring Imaging Cherenkov detector to perform a detailed characterisation of the magnetic distortion effects. It is described, along with the methods implemented to correct for these effects, restoring the optimal resolution.Comment: 16 pages, 11 figure

Niche and fitness differences relate the maintenance of diversity to ecosystem function: reply

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/134128/1/ecy20129361487.pd

Niche and fitness differences relate the maintenance of diversity to ecosystem function

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/116920/1/ecy20119251157.pd

Anthracycline-Induced Cardiotoxicity: Cardiac Monitoring by Continuous Wave-Doppler Ultrasound Cardiac Output Monitoring and Correlation to Echocardiography

Background: Anthracyclines are agents with a well-known cardiotoxicity. The study sought to evaluate the hemodynamic response to an anthracycline using real-time continuous-wave (CW)-Doppler ultrasound cardiac output monitoring (USCOM) and echocardiography in combination with serum biomarkers. Methods: 50 patients (26 male, 24 female, median age 59 years) suffering from various types of cancer received an anthracycline-based regimen. Patients' responses were measured at different time points (T0 prior to infusion, T1 6 h post infusion, T2 after 1 day, T3 after 7 days, and T4 after 3 months) with CW-Doppler ultrasound (T0-T4) and echocardiography (T1, T4) for hemodynamic parameters such as stroke volume (SV; SVUSCOM ml) and ejection fraction (EF; EFechocardiography%) and with NT-pro-BNP and hs-Troponin T (T0-T4). Results: During the 3-month observation period, the relative decrease in the EF determined by echocardiography was -2.1% (Delta T0-T4, T0 71 +/- 7.8%, T4 69.5 +/- 7%, p = 0.04), whereas the decrease in SV observed using CW-Doppler was -6.5% (Delta T0-T4, T0 54 +/- 19.2 ml, T4 50.5 +/- 20.6 ml, p = 0.14). The kinetics for serum biomarkers were inversely correlated. Conclusions: Combining real-time CW-Doppler USCOM and serum biomarkers is feasible for monitoring the immediate and chronic hemodynamic changes during an anthracycline-based regimen; the results obtained were comparable to those from echocardiography

RENEW-URBAN: COME ALBERI AL VENTO SOLARE

Il tema della riqualificazione del patrimonio edilizio residenziale esistente permette di affrontare alcune delle molteplici declinazioni del concetto di sostenibilità ambientale (riduzione delle risorse non rinnovabili e delle emissioni di CO2 in atmosfera) nei Paesi industrializzati, dove lo sviluppo di un economia orientata al profitto ha trasformato il costruito in un problema energetico planetario, rendendo impossibile una equilibrata convivenza fra uomo e natura. La volgarizzazione di modelli edilizi indifferenti ai luoghi ha causato il degrado del paesaggio urbano e il peggioramento delle condizioni di vita. L’evidente obsolescenza delle abitazioni realizzate dal dopoguerra in poi, responsabile di elevati consumi di energia, ha portato a progettare il recupero di un edificio a torre situato nel quartiere periferico San Paolo (Bari). L’innovativa proposta lo trasforma da elemento passivo ad elemento attivo per la produzione di energia elettrica e termica attraverso un up-grade architettonico determinante per il miglioramento di prestazioni estetiche, funzionali e spaziali. L’intervento di retrofit prevede l’installazione di un Kit Albero-Solare che, avvolgendo i fabbricati esistenti come una vera e propria “pelle solare”, introduce superfici ad hoc pensate per massimizzare la captazione di radiazione solare ed i benefici ambientali delle soluzioni proposte (muro verde, raccolta acqua meteoriche, sistemi di ombreggiamento etc.). Costituito da una serie integrata di sistemi solari attivi, sistemi passivi come serre solari o camminamenti esterni e sistemi di ventilazione, è indipendente dall’esposizione e dotato di flessibilità e replicabilità che lo rendono competitivo in termini di costi rispetto alle soluzioni più tradizionali. Gli elementi che lo compongono sono standardizzati, facili da assemblare grazie alla loro piccola dimensione e collaboranti ai fini del miglioramento delle caratteristiche strutturali dei manufatti. Grazie all’integrazione di tecnologie e materiali eco-compatibili e strumenti di calcolo all’avanguardia, la ricerca, finalizzata all'incremento dell'efficienza energetica dei contesti insediativi di margine, consente il pieno rispetto della normativa nazionale e regionale

Phylogenetic distance does not predict competition in green algal communities

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/116355/1/ecs214005021.pd

Precisely Engineered Supported Gold Clusters as a Stable Catalyst for Propylene Epoxidation

Designing a stable and selective catalyst with high H2 utilisation is of pivotal importance for the direct gas-phase epoxidation of propylene. This work describes a facile one-pot methodology to synthesise ligand-stabilised sub-nanometre gold clusters immobilised onto a zeolitic support (TS-1) to engineer a stable Au/TS-1 catalyst. A non-thermal O2 plasma technique is used for the quick removal of ligands with limited increase in particle size. Compared to untreated Au/TS-1 catalysts prepared using the deposition precipitation method, the synthesised catalyst exhibits improved catalytic performance, including 10 times longer lifetime (>20 days), increased PO selectivity and hydrogen efficiency in direct gas phase epoxidation. The structure-stability relationship of the catalyst is illustrated using multiple characterisation techniques, such as XPS, 31P MAS NMR, DR-UV/VIS, HRTEM and TGA. It is hypothesised that the ligands play a guardian role in stabilising the Au particle size, which is vital in this reaction. This strategy is a promising approach towards designing a more stable heterogeneous catalyst

Experimental evidence that evolutionary relatedness does not affect the ecological mechanisms of coexistence in freshwater green algae

The coexistence of competing species depends on the balance between their fitness differences, which determine their competitive inequalities, and their niche differences, which stabilise their competitive interactions. Darwin proposed that evolution causes species' niches to diverge, but the influence of evolution on relative fitness differences, and the importance of both niche and fitness differences in determining coexistence have not yet been studied together. We tested whether the phylogenetic distances between species of green freshwater algae determined their abilities to coexist in a microcosm experiment. We found that niche differences were more important in explaining coexistence than relative fitness differences, and that phylogenetic distance had no effect on either coexistence or on the sizes of niche and fitness differences. These results were corroborated by an analysis of the frequency of the co‐occurrence of 325 pairwise combinations of algal taxa in > 1100 lakes across North America. Phylogenetic distance may not explain the coexistence of freshwater green algae.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/100307/1/ele12182.pd