Avaliação da dinâmica do transporte dos bovinos no Pantanal Sul-Matogrossense.

O presente trabalho visou definir, caracterizar, classificar os modais de transporte de bovinos e avaliar as atuais condições da infra-estrutura logística dos meios de transporte em quatro sub-regiões do Pantanal (Paiaguás, Nhecolândia, Nabileque e Paraguai), através de duas abordagens: a avaliação da dinâmica do transporte e comercialização dos bovinos e a avaliação da dinâmica do transporte fluvial dos bovinos no porto de Ladário, MS. This study aimed define, characterize and classify the modal transport of beef cattle and assess the current conditions of the infrastructure in logistic of transport, in three subregion of Pantanal (Paiaguás, Nhecolandia, Nabileque and Paraguay), through two approaches: the assessment of the dynamics of the transport and marketing of cattle and evaluation of the dynamics of the fluvial transport of cattle in the port of Ladário, MS

The influence of progression of atrial fibrillation on quality of life: a report from the Euro Heart Survey.

Aims: Progression of atrial fibrillation (AF) from paroxysmal to persistent forms is an active field of research. The influence of AF progression on health related quality of life (HRQoL) is currently unknown. We aimed to assess the influence of AF progression on HRQoL, and whether this association is mediated through symptoms, treatment, and major adverse events. Methods and results: In the Euro Heart Survey, 967 patients were included with paroxysmal AF who filled out EuroQoL-5D at baseline and at 1 year follow-up. Those who progressed (n = 132, 13.6%) developed more problems during follow-up than those who did not, on all EuroQoL-5D domains (increase in problems on mobility 20.5% vs. 11.4%; self-care 12.9% vs. 6.2%; usual activities 23.5% vs. 14.0%; pain/discomfort 20.5% vs. 13.7%; and anxiety/depression 22.7% vs. 15.7%; all P < 0.05), leading to a decrease in utility [baseline 0.744 ± 0.26, follow-up 0.674 ± 0.36; difference -0.07 (95% CI [-0.126,-0.013], P = 0.02)]. Multivariate analysis showed that the effect of progression on utility is mediated by a large effect of adverse events [stroke (-0.27 (95% CI [-0.43,-0.11]); P = 0.001], heart failure [-0.12 (95% CI [-0.20,-0.05]); P = 0.001], malignancy (-0.31 (95% CI [-0.56,-0.05]); P = 0.02] or implantation of an implantable cardiac defibrillator [-0.12 (95% CI [-0.23,-0.02]); P = 0.03)], as well as symptomatic AF [-0.04 (95% CI [-0.08,-0.01]); P = 0.008]. Conclusion: AF progression is associated with a decrease in HRQoL. However, multivariate analysis revealed that AF progression itself does not have a negative effect on HRQoL, but that this effect can be attributed to a minor effect of the associated symptoms and a major effect of associated adverse events

Diegetic Representation of Feedback in Open Games

We improve the framework of open games with agency by showing how the players' counterfactual analysis giving rise to Nash equilibria can be described in the dynamics of the game itself (hence diegetically), getting rid of devices such as equilibrium predicates. This new approach overlaps almost completely with the way gradient-based learners are specified and trained. Indeed, we show feedback propagation in games can be seen as a form of backpropagation, with a crucial difference explaining the distinctive character of the phenomenology of non-cooperative games. We outline a functorial construction of arena of games, show players form a subsystem over it, and prove that their 'fixpoint behaviours' are Nash equilibria.Comment: In Proceedings ACT 2022, arXiv:2307.1551

Safety and efficacy of dronedarone from clinical trials to real-world evidence: implications for its use in atrial fibrillation.

Efficacy and safety of dronedarone was shown in the ATHENA trial for paroxysmal or persistent atrial fibrillation (AF) patients. Further trials revealed safety concerns in patients with heart failure and permanent AF. This review summarizes insights from recent real-world studies and meta-analyses, including reports on efficacy, with focus on liver safety, mortality risk in patients with paroxysmal/persistent AF, and interactions of dronedarone with direct oral anticoagulants. Reports of rapidly progressing liver failure in dronedarone-prescribed patients in 2011 led to regulatory cautions about potential liver toxicity. Recent real-world evidence suggests dronedarone liver safety profile is similar to other antiarrhythmics and liver toxicity could be equally common with many Class III antiarrhythmics. Dronedarone safety concerns (increased mortality in patients with permanent AF) were raised based on randomized controlled trials (RCT) (ANDROMEDA and PALLAS), but comedication with digoxin may have increased the mortality rates in PALLAS, considering the dronedarone-digoxin pharmacokinetic (PK) interaction. Real-world data on apixaban-dronedarone interactions and edoxaban RCT observations suggest no significant safety risks for these drug combinations. Median trough plasma concentrations of dabigatran 110 mg during concomitant use with dronedarone are at acceptable levels, while PK data on the rivaroxaban-dronedarone interaction are unavailable. In RCTs and real-world studies, dronedarone significantly reduces AF burden and cardiovascular hospitalizations, and demonstrates a low risk for proarrhythmia in patients with paroxysmal or persistent AF. The concerns on liver safety must be balanced against the significant reduction in hospitalizations in patients with non-permanent AF and low risk for proarrhythmias following dronedarone treatment

Organizing Physics with Open Energy-Driven Systems

Organizing physics has been a long-standing preoccupation of applied category theory, going back at least to Lawvere. We contribute to this research thread by noticing that Hamiltonian mechanics and gradient descent depend crucially on a consistent choice of transformation -- which we call a reaction structure -- from the cotangent bundle to the tangent bundle. We then construct a compositional theory of reaction structures. Reaction-based systems offer a different perspective on composition in physics than port-Hamiltonian systems or open classical mechanics, in that reaction-based composition does not create any new constraints that must be solved for algebraically. The technical contributions of this paper are the development of symmetric monoidal categories of open energy-driven systems and open differential equations, and a functor between them, functioning as a "functorial semantics" for reaction structures. This approach echoes what has previously been done for open games and open gradient-based learners, and in fact subsumes the latter. We then illustrate our theory by constructing an $n$-fold pendulum as a composite of $n$-many pendula.Comment: 14 pages, 3 figures, Submitted to Applied Category Theory 202

In Car Audio

This chapter presents implementations of advanced in Car Audio Applications. The system is composed by three main different applications regarding the In Car listening and communication experience. Starting from a high level description of the algorithms, several implementations on different levels of hardware abstraction are presented, along with empirical results on both the design process undergone and the performance results achieved

On Quantifiers for Quantitative Reasoning

We explore a kind of first-order predicate logic with intended semantics in the reals. Compared to other approaches in the literature, we work predominantly in the multiplicative reals $[0,\infty]$, showing they support three generations of connectives, that we call non-linear, linear additive, and linear multiplicative. Means and harmonic means emerge as natural candidates for bounded existential and universal quantifiers, and in fact we see they behave as expected in relation to the other logical connectives. We explain this fact through the well-known fact that min/max and arithmetic mean/harmonic mean sit at opposite ends of a spectrum, that of p-means. We give syntax and semantics for this quantitative predicate logic, and as example applications, we show how softmax is the quantitative semantics of argmax, and R\'enyi entropy/Hill numbers are additive/multiplicative semantics of the same formula. Indeed, the additive reals also fit into the story by exploiting the Napierian duality $-\log \dashv 1/\exp$, which highlights a formal distinction between 'additive' and 'multiplicative' quantities. Finally, we describe two attempts at a categorical semantics via enriched hyperdoctrines. We discuss why hyperdoctrines are in fact probably inadequate for this kind of logic.Comment: (21 pages, 1 figure, 2 tables) -- v4: minor edits and typos correction