Tunnelling Effects in a Brane System and Quantum Hall Physics

We argue that a system of interacting D-branes, generalizing a recent proposal, can be modelled as a Quantum Hall fluid. We show that tachyon condensation in such a system is equivalent to one particle tunnelling. In a conformal field theory effective description, that induces a transition from a theory with central charge c=2 to a theory with c=3/2, with a corresponding symmetry enhancement.Comment: 12 pages, no figures, Latex, some aspects clarified, sect.3 expanded, references adde

Search for the decay K+ to pi+ gamma gamma in the pi+ momentum region P>213 MeV/c

We have searched for the K+ to pi+ gamma gamma decay in the kinematic region with pi+ momentum close to the end point. No events were observed, and the 90% confidence-level upper limit on the partial branching ratio was obtained, B(K+ to pi+ gamma gamma, P>213 MeV/c) < 8.3 x 10-9 under the assumption of chiral perturbation theory including next-to-leading order ``unitarity'' corrections. The same data were used to determine an upper limit on the K+ to pi+ gamma branching ratio of 2.3 x 10-9 at the 90% confidence level.Comment: 15 pages, 3 figures; no change in the results, accepted for publication in Physics Letters

Role of Scalar Meson Resonances in $K_{L}^{0} \rightarrow \pi^{0} \gamma \gamma Decay

Corrections to $K_{L}^{0}\rightarrow \pi^{0} \gamma \gamma$ decay induced by scalar meson exchange are studied within chiral perturbation theory. In spite of bad knowledge of scalar-mesons parameters, the calculated branching ratio can be changed by a few percent.Comment: 18 pages of text, 2 figures (available upon request); preprint IJS-TP-16-94 , TUM-T31-63-94

On the Evaluation of Gluon Condensate Effects in the Holographic Approach to QCD

In holographic QCD the effects of gluonic condensate can be encoded in a suitable deformation of the 5D metric. We develop two different methods for the evaluation of first order perturbative corrections to masses and decay constants of vector resonances in 5D Hard-Wall models of QCD due to small deformations of the metric. They are extracted either from a novel compact form for the first order correction to the vector two-point function, or from perturbation theory for vector bound-state eigenfunctions: the equivalence of the two methods is shown. Our procedures are then applied to flat and to AdS 5D Hard-Wall models; we complement results of existing literature evaluating the corrections to vector decay constant and to two-pion-one-vector couplings: this is particularly relevant to satisfy the sum rules. We concentrate our attention on the effects for the Gasser-Leutwyler coefficients; we show that, as in the Chiral Quark model, the addition of the gluonic condensate improves the consistency, the understanding and the agreement with phenomenology of the holographic model.Comment: 23 pages, three figures, sign error in pion wave function fixed, numerical analysis extended, general conclusions unchange

In search for multi-target ligands as potential agents for diabetes mellitus and its complications—a structure-activity relationship study on inhibitors of aldose reductase and protein tyrosine phosphatase 1b

Diabetes mellitus (DM) is a complex disease which currently affects more than 460 million people and is one of the leading cause of death worldwide. Its development implies numerous metabolic dysfunctions and the onset of hyperglycaemia-induced chronic complications. Multiple ligands can be rationally designed for the treatment of multifactorial diseases, such as DM, with the precise aim of simultaneously controlling multiple pathogenic mechanisms related to the disease and providing a more effective and safer therapeutic treatment compared to combinations of selective drugs. Starting from our previous findings that highlighted the possibility to target both aldose reductase (AR) and protein tyrosine phosphatase 1B (PTP1B), two enzymes strictly implicated in the development of DM and its complications, we synthesised 3-(5-arylidene-4-oxothiazolidin-3-yl)propanoic acids and analogous 2-butenoic acid derivatives, with the aim of balancing the effectiveness of dual AR/PTP1B inhibitors which we had identified as designed multiple ligands (DMLs). Out of the tested compounds, 4f exhibited well-balanced AR/PTP1B inhibitory effects at low micromolar concentrations, along with interesting insulin-sensitizing activity in murine C2C12 cell cultures. The SARs here highlighted along with their rationalization by in silico docking experiments into both target enzymes provide further insights into this class of inhibitors for their development as potential DML antidiabetic candidates

The standard model at low energies

The hadronic sector of the standard model at low energies is described by a non--decoupling effective field theory, chiral perturbation theory. An introduction is given to the construction of effective chiral Lagrangians, both in the purely mesonic sector and with inclusion of baryons. The connection between the relativistic formulation and the heavy baryon approach to chiral perturbation theory with baryons is reviewed.Comment: Lectures given at the 6th Indian-Summer School on Intermediate Energy Physics, Prague, Aug. 1993, Latex, 26 pages (with a4.sty), UWThPh-1993-3

dS/CFT Duality on the Brane with a Topological Twist

We consider a brane universe in an asymptotically de Sitter background spacetime of arbitrary dimensionality. In particular, the bulk spacetime is described by a ``topological de Sitter'' solution, which has recently been investigated by Cai, Myung and Zhang. In the current study, we begin by showing that the brane evolution is described by Friedmann-like equations for radiative matter. Next, on the basis of the dS/CFT correspondence, we identify the thermodynamic properties of the brane universe. We then demonstrate that many (if not all) of the holographic aspects of analogous AdS-bulk scenarios persist. These include a (generalized) Cardy-Verlinde form for the CFT entropy and various coincidences when the brane crosses the cosmological horizon.Comment: 24 pages, Latex; references added and Section 5 enhance

Chiral perturbation theory

The main elements and methods of chiral perturbation theory, the effective field theory of the Standard Model below the scale of spontaneous chiral symmetry breaking, are summarized. Applications to the interactions of mesons and baryons at low energies are reviewed, with special emphasis on developments of the last three years. Among the topics covered are the strong, electromagnetic and semileptonic weak interactions of mesons at and beyond next--to--leading order in the chiral expansion, nonleptonic weak interactions of mesons, virtual photon corrections and the meson--baryon system. The discussion is limited to processes at zero temperature, for infinite volume and with at most one baryon.Comment: 84 pages, Latex, 11 PostScript figures (in separate file) embedded with epsfig.sty, complete ps file (compressed, uuencoded, 0.6 MB) available via email on request; to appear in Progr. Part. Nucl. Phys., vol. 3

Deriving the mass of particles from Extended Theories of Gravity in LHC era

We derive a geometrical approach to produce the mass of particles that could be suitably tested at LHC. Starting from a 5D unification scheme, we show that all the known interactions could be suitably deduced as an induced symmetry breaking of the non-unitary GL(4)-group of diffeomorphisms. The deformations inducing such a breaking act as vector bosons that, depending on the gravitational mass states, can assume the role of interaction bosons like gluons, electroweak bosons or photon. The further gravitational degrees of freedom, emerging from the reduction mechanism in 4D, eliminate the hierarchy problem since generate a cut-off comparable with electroweak one at TeV scales. In this "economic" scheme, gravity should induce the other interactions in a non-perturbative way.Comment: 30 pages, 1 figur

Anti-de Sitter Black Holes, Thermal Phase Transition and Holography in Higher Curvature Gravity

We study anti-de Sitter black holes in the Einstein-Gauss-Bonnet and the generic R^2 gravity theories, evaluate different thermodynamic quantities, and also examine the possibilities of Hawking-Page type thermal phase transitions in these theories. In the Einstein theory, with a possible cosmological term, one observes a Hawking-Page phase transition only if the event horizon is a hypersurface of positive constant curvature (k=1). But, with the Gauss-Bonnet or/and the (Riemann)^2 interaction terms, there may occur a similar phase transition for a horizon of negative constant curvature (k=-1). We examine the finite coupling effects, and find that N>5 could trigger a Hawking-Page phase transition in the latter theory. For the Gauss-Bonnet black holes, one relates the entropy of the black hole to a variation of the geometric property of the horizon based on first law and Noether charge. With (Riemann)^2 term, however, we can do this only approximately, and the two results agree when, r_H>>L, the size of the horizon is much bigger than the AdS curvature scale. We establish some relations between bulk data associated with the AdS black hole and boundary data defined on the horizon of the AdS geometry. Following a heuristic approach, we estimate the difference between Hubble entropy {\cal S}_H and Bekenstein-Hawking entropy {\cal S}_{BH} with (Riemann)^2 term, which, for k=0 and k=-1, would imply {\cal S}_{BH}\leq {\cal S}_H.Comment: 22 pages, Revtex 4, 12+1 figures, references added, section V extended. To appear in PR