Novel Pharmacological Targets of Post-Traumatic Stress Disorders

Post-traumatic stress disorder (PTSD) is a psychopathological condition with a heteroge- neous clinical picture that is complex and challenging to treat. Its multifaceted pathophysiology still remains an unresolved question and certainly contributes to this issue. The pharmacological treatment of PTSD is mainly empirical and centered on the serotonergic system. Since the therapeutic response to prescribed drugs targeting single symptoms is generally inconsistent, there is an urgent need for novel pathogenetic hypotheses, including different mediators and pathways. This paper was conceived as a narrative review with the aim of debating the current pharmacological treatment of PTSD and further highlighting prospective targets for future drugs. The authors accessed some of the main databases of scientific literature available and selected all the papers that fulfilled the purpose of the present work. The results showed that most of the current pharmacological treatments for PTSD are symptom-based and show only partial benefits; this largely reflects the limited knowledge of its neurobiology. Growing, albeit limited, data suggests that the hypothalamic-pituitary-adrenal axis, opioids, glutamate, cannabinoids, oxytocin, neuropeptide Y, and microRNA may play a role in the development of PTSD and could be targeted for novel treatments. Indeed, recent research indicates that examining different pathways might result in the development of novel and more efficient drugs

Putting families of origin into the queer picture : introducing this special issue

In undertaking our own separate research projects and in our crosscontinental comparative analyses of those projects, we became aware of the gaps between the richness of research on GLBT lives, including experiences of intimacy and parenthood, and the paucity of research on their relations with their families of origin. Still marginal is, in particular, research on the perspectives of the families of origin themselves: parents, but also siblings, grandparents, and other members of extended families. For the purposes of this special issue, we are deploying the term families of origin to mean heterosexual-identifying family members (at least as they publicly perform and display their sexualities), living within a heteronormative socio-politicocultural system. As we will argue in this introduction, however, there is a need to document and research, and thereby historically situate, family diversity, including the increasing shifting discourses and lived experiences of same-sex and other queer families of origin

Edoardo Narne Architetture 1999-2009

Nell lavoro di Edoardo Narne di questi dieci anni traspaiono sia il riferimento alla cultura e alla tradizione indiana, sia la cultura figurativa e spaziale dei maestri del Moderno. La prima si trasforma spesso in allusione pi\uf9 che in citazione letteraria e stilistica, anche quando la localizzazione del progetto potrebbe indurlo se non imporlo. La grande lezione del sincretismo culturale indiano si traduce invece in un\u2019attitudine a cogliere i suggerimenti del luogo inteso nel senso pi\uf9 ampio del termine e in una particolare concezione dello spazio come stato mentale unitario che difficilmente pu\uf2 essere scomposto in piante e sezioni. A questa matrice spaziale della ricerca architettonica \ue8 da ricondursi anche l\u2019altra importante esperienza, maturata durante l\u2019esperienza spagnola, costituita dalla cultura mediterranea e dalla particolare interpretazione che questa ha dato del Moderno, inteso come rivoluzione nello spazio oltre che in pianta. A questa matrice spaziale della ricerca architettonica \ue8 da ricondursi anche l\u2019altra importante esperienza, maturata durante l\u2019esperienza spagnola, costituita dalla cultura mediterranea e dalla particolare interpretazione che questa ha dato del Moderno, inteso come rivoluzione nello spazio oltre che in pianta. A questo pu\uf2 essere ricondotto l\u2019approfondimento dello spazio nella scultura di Oteiza.Da qui l\u2019attenzione a tutti quegli elementi che permettono di realizzare questi spazi di transizione, filtri, diaframmi, vuoti trattati come materia plastica, e di caratterizzarli, attraverso il colore, la luce oppure la sezione stessa dell\u2019edificio. \uc8 dunque in questi passaggi, in questi interstizi spaziali che si concentra lo studio di un dettaglio che va dalla scelta di un materiale in base al colore o alla texture, della luce trattata come materia compositiva, fino alla configurazione morfologica dello spazio interno che finisce poi per plasmare l\u2019esterno. Se la storia del secolo appena concluso ci dice che il confronto con la tradizione non \ue8 una scelta, ma un obbligo, pi\uf9 o meno sofferto che sia, scorrendo le opere costruite e quelle solo progettate, si pu\uf2 affermare tuttavia che nel modo con cui ripercorrere le strade della tradizione risiede ancora la possibilit\ue0 di costruire l\u2019originalit\ue0 dell\u2019Architettura

Workplace situations: the assessment of emotionally un/intelligent reactions.

Introduction. Identifying and expressing one\u2019s own and others\u2019 emotions, and, if necessary, regulating them, are assumed to be skills that denote Emotional Intelligence (EI). Such skills are likely to be crucial in work settings in that they contribute to define both the functioning and wellbeing of employees. Aim. The present study, part of a broader ongoing research project on EI skills especially in career starters (e.g., Zammuner & Kafetsios, 2005; Zammuner 2007), focuses on the role EI plays in how people react, emotionally and behaviorally, in a variety of work situations. Age and gender differences in the exhibited skill levels were also tested. Method. 147 participants (45.6% male; M age = 35.65, sd 12,1) evaluated on interval scales the adequacy of a number of reactions to each of several work events described in a vignette. They additionally filled in other sections of TIEIT (Test of Emotional Intelligence- Italian) \u2013 e.g., on emotional labor and job involvement. Results. Results showed that reactions to work situations are accounted for by a number of emotion-related dimensions (e.g., empathic vs. \u2018cold\u2019 reactions) and vary as a function of age and gender. Significant correlations with other tested variables were also observed