R. U. R. (Rossum\u27s Universal Robots)

Robots of the world! The power of man has fallen! A new world has arisen: the Rule of the Robots! March

R.U.R.

R.U.R., or Rossum’s Universal Robots is a play written in 1920 by Karel Čapek, a Czech writer who wrote many plays and novels, many of them with science-fiction and dystopian themes. R.U.R. is perhaps the most well-known of these works in the English-speaking world because it brought the word “robot” into the language. “Robot” is derived from the Czech word meaning “worker.” The play is set in the island headquarters of the R.U.R. corporation. The corporation has been manufacturing artificial beings which resemble humans, but who are tireless workers. They can be mass-produced in large numbers and are being adopted as workers in many countries. In the first scene of the play, they are visited by a young woman, Helena Glory, who aspires to relieve the lot of the robots, who she sees as oppressed. However, in what must be the fastest seduction scene in all drama, she is wooed and agrees to marry Harry Domin, the factory manager, who she has just met. She still however aspires to improve the life of robots and find a way to give them souls. Ultimately, however, this admirable desire leads to disaster for humankind. The play was translated into English, and slightly abridged, by Paul Selver and Nigel Playfair in 1923. This version quickly became popular with both British and American audiences and was well received by critics. [Abstract from Standard eBooks

Small Train Station

3 pages

Co-administration of vancomycin and piperacillin-tazobactam is associated with increased renal dysfunction in adult and pediatric burn patients

Background: Burn patients are prone to infections which often necessitate broad antibiotic coverage. Vancomycin is a common antibiotic after burn injury and is administered alone (V), or in combination with imipenem-cilastin (V/IC) or piperacillin-tazobactam (V/PT). Sparse reports indicate that the combination V/PT is associated with increased renal dysfunction. The purpose of this study was to evaluate the short-term impact of the three antibiotic administration types on renal dysfunction. Methods: All pediatric and adult patients admitted to our centers between 2004 and 2016 with a burn injury were included in this retrospective review if they met the criteria of exposition to either V, V/IC, or V/PT for at least 48 h, had normal baseline creatinine, and no pre-existing renal dysfunction. Creatinine was monitored for 7 days after initial exposure; the absolute and relative increase was calculated, and patient renal outcomes were classified according to the Kidney Disease Improving Global Outcomes (KDIGO) criteria depending on creatinine increases and estimated creatinine clearance. Secondary endpoints (demographic and clinical data, incidences of septicemia, and renal replacement therapy) were analyzed. Antibiotic doses were modeled in logistic and linear multivariable regression models to predict categorical KDIGO events and relative creatinine increase. Results: Out of 1449 patients who were screened, 718 met the inclusion criteria, 246 were adults, and 472 were children. Between the study cohorts V, V/IC, and V/PT, patient characteristics at admission were comparable. V/PT administration was associated with a statistically higher serum creatinine, and lower creatinine clearance compared to patients receiving V alone or V/IC in adults and children after burn injury. The incidence of KDIGO stages 1, 2, and 3 was higher after V/PT treatment. In children, the incidence of KDIGO stage 3 following administration of V/PT was greater than after V/IC. In adults, the incidence of renal replacement therapy was higher after V/PT compared with V or V/IC. Multivariate modeling demonstrated that V/PT is an independent predictor of renal dysfunction. Conclusion: Co-administration of vancomycin and piperacillin-tazobactam is associated with increased renal dysfunction in pediatric and adult burn patients when compared to vancomycin alone or vancomycin plus imipenem-cilastin. The mechanism of this increased nephrotoxicity remains elusive and warrants further scientific evaluation

Voices from Germany

1 page

Lásky hra osudná

63 pagesA one act play by Karel and Josef Čapek published in 1910, and later translated from the Czech by Norma (Bean) Comrada

Little Radio Report: End of the XXth Century

1 page

The Insect Comedy (March 17-18, 1967)

Program for The Insect Comedy (March 17-18, 1967)