Caracterização do comportamento sísmico de edifícios de betão armado representativos do edificado português sem dimensionamento sismorresistente

Uma parte significativa do edificado em Portugal não foi dimensionada para resistir a ações sísmicas. Como tal, o recente impulso do sector da reabilitação pode representar uma oportunidade única para promover a redução da vulnerabilidade sísmica dos edifícios existentes. Neste contexto, o presente trabalho apresenta uma metodologia para avaliar a vulnerabilidade sísmica duma classe de edifícios de betão armado que permite estabelecer indicadores simplificados do seu desempenho estrutural expectável. A metodologia proposta baseia-se num estudo numérico detalhado do comportamento sísmico de edifícios de betão armado com características representativas duma parte significativa do edificado deste tipo em Portugal, simulando de forma adequada os principais aspetos da sua resposta estrutural. Os resultados obtidos pela metodologia desenvolvida permitem identificar as principais vulnerabilidades do edificado e quantificar indicadores de desempenho estrutural que permitem avaliar de forma expedita a sua segurança estrutural.info:eu-repo/semantics/publishedVersio

Caracterização do comportamento sísmico de edifícios de betão armado representativos do edificado português sem dimensionamento sismorresistente

Uma parte significativa do edificado em Portugal não foi dimensionada para resistir a ações sísmicas. Como tal, o recente impulso do sector da reabilitação pode representar uma oportunidade única para promover a redução da vulnerabilidade sísmica dos edifícios existentes. Neste contexto, o presente trabalho apresenta uma metodologia para avaliar a vulnerabilidade sísmica duma classe de edifícios de betão armado que permite estabelecer indicadores simplificados do seu desempenho estrutural expectável. A metodologia proposta baseia-se num estudo numérico detalhado do comportamento sísmico de edifícios de betão armado com características representativas duma parte significativa do edificado deste tipo em Portugal, simulando de forma adequada os principais aspetos da sua resposta estrutural. Os resultados obtidos pela metodologia desenvolvida permitem identificar as principais vulnerabilidades do edificado e quantificar indicadores de desempenho estrutural que permitem avaliar de forma expedita a sua segurança estrutural.A significant part of the Portuguese building stock was not designed considering seismic provisions. As such, the recent growth of the building rehabilitation sector may represent a unique opportunity to reduce the seismic vulnerability of existing buildings, and consequently the associated earthquake risk. In this context, the present work presents a methodology to evaluate the seismic vulnerability of a class of reinforced concrete buildings and allows the definition of simplified indicators representing their expected structural performance. The proposed methodology is based on a detailed numerical study of the seismic behaviour of reinforced concrete buildings with representative characteristics of a significant part of the Portuguese building stock that adequately simulates the main aspects of the buildings' structural response. The results obtained by the methodology highlight the main vulnerabilities of the chosen building class and enable the quantification of structural performance indicators that can be used for the simplified structural safety assessment of similar structures

Shake‑table testing of a stone masonry building aggregate: overview of blind prediction study

City centres of Europe are often composed of unreinforced masonry structural aggregates, whose seismic response is challenging to predict. To advance the state of the art on the seismic response of these aggregates, the Adjacent Interacting Masonry Structures (AIMS) subproject from Horizon 2020 project Seismology and Earthquake Engineering Research Infrastructure Alliance for Europe (SERA) provides shake-table test data of a two-unit, double-leaf stone masonry aggregate subjected to two horizontal components of dynamic excitation. A blind prediction was organized with participants from academia and industry to test modelling approaches and assumptions and to learn about the extent of uncertainty in modelling for such masonry aggregates. The participants were provided with the full set of material and geometrical data, construction details and original seismic input and asked to predict prior to the test the expected seismic response in terms of damage mechanisms, base-shear forces, and roof displacements. The modelling approaches used differ significantly in the level of detail and the modelling assumptions. This paper provides an overview of the adopted modelling approaches and their subsequent predictions. It further discusses the range of assumptions made when modelling masonry walls, floors and connections, and aims at discovering how the common solutions regarding modelling masonry in general, and masonry aggregates in particular, affect the results. The results are evaluated both in terms of damage mechanisms, base shear forces, displacements and interface openings in both directions, and then compared with the experimental results. The modelling approaches featuring Discrete Element Method (DEM) led to the best predictions in terms of displacements, while a submission using rigid block limit analysis led to the best prediction in terms of damage mechanisms. Large coefficients of variation of predicted displacements and general underestimation of displacements in comparison with experimental results, except for DEM models, highlight the need for further consensus building on suitable modelling assumptions for such masonry aggregates

The Changing Landscape for Stroke\ua0Prevention in AF: Findings From the GLORIA-AF Registry Phase 2

Background GLORIA-AF (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients with Atrial Fibrillation) is a prospective, global registry program describing antithrombotic treatment patterns in patients with newly diagnosed nonvalvular atrial fibrillation at risk of stroke. Phase 2 began when dabigatran, the first non\u2013vitamin K antagonist oral anticoagulant (NOAC), became available. Objectives This study sought to describe phase 2 baseline data and compare these with the pre-NOAC era collected during phase 1. Methods During phase 2, 15,641 consenting patients were enrolled (November 2011 to December 2014); 15,092 were eligible. This pre-specified cross-sectional analysis describes eligible patients\u2019 baseline characteristics. Atrial fibrillation disease characteristics, medical outcomes, and concomitant diseases and medications were collected. Data were analyzed using descriptive statistics. Results Of the total patients, 45.5% were female; median age was 71 (interquartile range: 64, 78) years. Patients were from Europe (47.1%), North America (22.5%), Asia (20.3%), Latin America (6.0%), and the Middle East/Africa (4.0%). Most had high stroke risk (CHA2DS2-VASc [Congestive heart failure, Hypertension, Age  6575 years, Diabetes mellitus, previous Stroke, Vascular disease, Age 65 to 74 years, Sex category] score  652; 86.1%); 13.9% had moderate risk (CHA2DS2-VASc = 1). Overall, 79.9% received oral anticoagulants, of whom 47.6% received NOAC and 32.3% vitamin K antagonists (VKA); 12.1% received antiplatelet agents; 7.8% received no antithrombotic treatment. For comparison, the proportion of phase 1 patients (of N = 1,063 all eligible) prescribed VKA was 32.8%, acetylsalicylic acid 41.7%, and no therapy 20.2%. In Europe in phase 2, treatment with NOAC was more common than VKA (52.3% and 37.8%, respectively); 6.0% of patients received antiplatelet treatment; and 3.8% received no antithrombotic treatment. In North America, 52.1%, 26.2%, and 14.0% of patients received NOAC, VKA, and antiplatelet drugs, respectively; 7.5% received no antithrombotic treatment. NOAC use was less common in Asia (27.7%), where 27.5% of patients received VKA, 25.0% antiplatelet drugs, and 19.8% no antithrombotic treatment. Conclusions The baseline data from GLORIA-AF phase 2 demonstrate that in newly diagnosed nonvalvular atrial fibrillation patients, NOAC have been highly adopted into practice, becoming more frequently prescribed than VKA in Europe and North America. Worldwide, however, a large proportion of patients remain undertreated, particularly in Asia and North America. (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients With Atrial Fibrillation [GLORIA-AF]; NCT01468701

Seismic testing of adjacent interacting masonry structures – shake table test and blind prediction competition

Across historical centres in Europe, stone masonry buildings form building aggregates that developed as the layout of the city or village was densified. In these aggregates, adjacent buildings can share structural walls with an older and a newer unit connected either by interlocking stones or by a layer of mortar. Observations after for example the recent Central Italy earthquakes showed that joints between the buildings were often the first elements to be damaged, leading to a complex interaction between the units. The analysis of such building aggregates is difficult due to the lack of guidelines, as the advances were impeded by the scarce experimental data. Therefore, the objective of the project AIMS (Seismic Testing of Adjacent Interacting Masonry Structures), included in the H2020 project SERA, was to provide such data by testing an aggregate of two double-leaf stone masonry buildings under two horizontal components of dynamic excitation. The test units were constructed at half-scale, with a two-storey building and a one-storey building. The buildings shared one common wall, while only a layer of mortar connected the façade walls. The floors were at different heights and had different beam orientations. Prior to the test, a blind prediction competition was organized with twelve participants from academia and industry that were provided with all the geometrical and material data, construction details, and the seismic input. The participants were asked to report results in terms of damage mechanisms, recorded displacements and base shear values. Results of the shake-table campaign are reported, together with a comparison with the blind predictions. Large scatter in terms of reported predictions highlights the impact of modelling uncertainties and the need for further tests

Correction to: Comparative effectiveness and safety of non-vitamin K antagonists for atrial fibrillation in clinical practice: GLORIA-AF Registry

International audienceIn this article, the name of the GLORIA-AF investigator Anastasios Kollias was given incorrectly as Athanasios Kollias in the Acknowledgements. The original article has been corrected

Patterns of oral anticoagulant use and outcomes in Asian patients with atrial fibrillation: a post-hoc analysis from the GLORIA-AF Registry

Background: Previous studies suggested potential ethnic differences in the management and outcomes of atrial fibrillation (AF). We aim to analyse oral anticoagulant (OAC) prescription, discontinuation, and risk of adverse outcomes in Asian patients with AF, using data from a global prospective cohort study. Methods: From the GLORIA-AF Registry Phase II-III (November 2011-December 2014 for Phase II, and January 2014-December 2016 for Phase III), we analysed patients according to their self-reported ethnicity (Asian vs. non-Asian), as well as according to Asian subgroups (Chinese, Japanese, Korean and other Asian). Logistic regression was used to analyse OAC prescription, while the risk of OAC discontinuation and adverse outcomes were analysed through Cox-regression model. Our primary outcome was the composite of all-cause death and major adverse cardiovascular events (MACE). The original studies were registered with ClinicalTrials.gov, NCT01468701, NCT01671007, and NCT01937377. Findings: 34,421 patients were included (70.0 ± 10.5 years, 45.1% females, 6900 (20.0%) Asian: 3829 (55.5%) Chinese, 814 (11.8%) Japanese, 1964 (28.5%) Korean and 293 (4.2%) other Asian). Most of the Asian patients were recruited in Asia (n = 6701, 97.1%), while non-Asian patients were mainly recruited in Europe (n = 15,449, 56.1%) and North America (n = 8378, 30.4%). Compared to non-Asian individuals, prescription of OAC and non-vitamin K antagonist oral anticoagulant (NOAC) was lower in Asian patients (Odds Ratio [OR] and 95% Confidence Intervals (CI): 0.23 [0.22-0.25] and 0.66 [0.61-0.71], respectively), but higher in the Japanese subgroup. Asian ethnicity was also associated with higher risk of OAC discontinuation (Hazard Ratio [HR] and [95% CI]: 1.79 [1.67-1.92]), and lower risk of the primary composite outcome (HR [95% CI]: 0.86 [0.76-0.96]). Among the exploratory secondary outcomes, Asian ethnicity was associated with higher risks of thromboembolism and intracranial haemorrhage, and lower risk of major bleeding. Interpretation: Our results showed that Asian patients with AF showed suboptimal thromboembolic risk management and a specific risk profile of adverse outcomes; these differences may also reflect differences in country-specific factors. Ensuring integrated and appropriate treatment of these patients is crucial to improve their prognosis. Funding: The GLORIA-AF Registry was funded by Boehringer Ingelheim GmbH