Research on fault self-healing strategy of a distribution network considering wind and solar accommodation capacity

As a traditional fault recovery strategy, network reconfiguration changes the structure of a distribution network by changing the switching state to achieve a normal power supply for non-fault power loss. Distributed access, such as wind power and photovoltaics, will cause voltage and frequency fluctuations. Traditional tie switches cannot adapt to this change, which may lead to reconstruction failure. A flexible interconnection device can suppress the negative impact of these large-scale sources and loads with strong uncertainty and volatility on the power supply quality and system stability. This paper proposes a fault recovery strategy for a distribution network considering wind and solar consumption. First, through the analysis of the fault recovery process of a distribution network, it is proposed that the fault recovery of a distribution network can be realized by distribution network reconfiguration. Then, by analyzing the characteristics of the flexible interconnection device, it is shown that the flexible interconnection device can adapt well to the distribution network with new energy access. Finally, this paper constructs a multi-objective optimization reconfiguration model of a distribution network considering wind and solar consumption capacity and verifies the effectiveness of the scheme in improving wind and solar consumption capacity and solving economic problems through case analysis

MiR-501-3p/SPC24 axis affects cell proliferation, migration, invasion, apoptosis, and prognosis in renal cell carcinoma

It has been confirmed that the expression of miR-501-3p is closely related to the behavior of several cancers. This study aimed to elucidate the effects of miR-501-3p/SPC24 axis on the behavior of renal cancer cells and to identify its prognostic value in renal cancer. First, the expression of miR-501-3p in the renal cell carcinoma (RCC) cell line was detected using real-time quantitative polymerase chain reaction (RT-qPCR). Second, cell function identification experiments were performed, including CCK-8, scratch, transwell invasion, and flow cytometry assays. Several databases were applied to explore the possible mechanism of miR-501-3p tumor suppressor effect in RCC. To explore the value of miR-501-3p/SPC24 axis in predicting renal cancer patient overall survival (OS), GEPIA (http://gepia.cancer-pku.cn/index.html) was used. Finally, western blot was performed to detect the expression level of SPC24 in renal cancer cells predicted by bioinformatics analysis. Dual-Luciferase Reporter Assay was used to verify if SPC24 is a target of mir-501-3p. MiR-501-3p was found to be down-regulated in cancer cells and tissues and to play a role in suppressing tumor cell proliferation, cell viability, cell migration, and cell invasion, while promoting apoptosis. We also found that high expression levels of SPC24 were associated with shorter OS time in patients diagnosed with renal cell carcinoma. In addition, the results of TCGA data analysis and western blot showed that the tumor suppressor effect of miR-501-3p may be achieved by targeting SPC24. The MiR-501-3p/SPC24 axis affects cell proliferation, migration, invasion, apoptosis, and prognosis in renal cell carcinoma

Reduced abundance of Fusobacterium signifies cardiovascular benefits of sodium glucose cotransporter 2 inhibitor in type 2 diabetes: a single arm clinical trial

BackgroundThe sodium glucose cotransporter 2 inhibitor (SGLT2i) dapagliflozin has been demonstrated cardiovascular benefits in patients with type 2 diabetes mellitus (T2DM). However, the underlying mechanism remains poorly understood.MethodsWe conducted an 8-week, single-arm clinical trial, which enrolled 12 patients with inadequate glycemic control on metformin monotherapy. These patients were treated with SGLT2i dapagliflozin (10 mg/day). We assessed changes in clinical parameters pertinent to glucose metabolism and risk factors of cardiovascular disease (CVD), as well as alterations in the gut microbiota using macrogene sequencing.ResultsImprovements were observed in anthropometric parameters, glucose metabolism, blood lipid-related indices, inflammatory markers, and endothelial cell function-related parameters. Concurrently, SGLT2i led to changes in composition and functional pathways of the gut microbiota, manifested as increased abundance of probiotics and decreased abundance of harmful bacteria. Importantly, reduced abundance of Fusobacterium was correlated with improvements in various clinical indicators.ConclusionSGLT2i represents a superior initial therapeutic option for T2DM patients at risk of CVD. The cardiovascular benefits of SGLT2i may be attributed to shifts in the gut microbiota, particularly the reduced abundance of Fusobacterium

Characteristics and sources of tissue-resident memory T cells in psoriasis relapse

Tissue-resident memory T cells (Trm) are a sub-population of memory T cells that reside in skin tissue. Recent studies have revealed potential role of Trm in the reoccurrence of psoriasis, as these cells tend to be profusely infiltrated in the lesions observed during psoriasis relapse. Trm can be classified into CD8+ Trm cells that are distributed mainly in the epidermis and CD4+ Trm cells in the dermis. CD8+ Trm is derived from circulating memory T cells and CD49a−CD8+ Trm takes a crucial role in psoriasis relapse. In contrast, CD4+ Trm may originate from exTh17 cells and exTreg cells emerging from the inflammatory process. Since IL-23 can activate Trm, neutralizing antibodies against IL-23 are suggested to be more effective in clinical treatment. This review will focus on Trm cells in psoriasis relapsed lesions to reveal their mechanisms in the pathogenesis, relapse and transformation of psoriasis

Circular RNA atlas in osteoclast differentiation with and without alendronate treatment

Abstract Background Alendronate (AL) is the most widely used bisphosphonate in the treatment of osteoporosis (OP). However, the role of circular RNAs (circRNAs) in the treatment of OP with AL remains unclear. Methods In this study, we showed that osteoclast (OC) precursors (OPCSs) could be induced into OCs with macrophage colony-stimulating factor (MCSF) and receptor activator of nuclear factor-κB ligand (RANKL) treatment. Subsequently, the OCs were treated with AL. OC differentiation-related biomarkers including RANK, tartrate-resistant acid phosphatase (TRAP), and cathepsin K (CTSK) were analyzed with TRAP staining, quantitative real-time (qPCR), and western blotting. Differentially expressed circRNAs (DECs) were identified among the OPCS, OC, and OC + AL groups. In addition, the expression levels of 10 DECs related to OC differentiation were verified by qPCR. Results TRAP staining showed that MCSF and RANKL treatment effectively induced OPCSs to differentiate into OCs. In addition, qPCR and western blot analysis revealed that the three biomarkers of OC (RANK, TRAP, and CTSK) were expressed significantly more in the OC group than those in the OPCS group. In contrast, the mRNA and protein expression levels of these three biomarkers decreased significantly in OCs treated with AL compared with those non-treated OCs. GO analysis of the DECs in the OPCS group vs. the OC group revealed that their functions were mainly related to cell, cell part, binding, and single-organism terms. KEGG analysis of the top 20 DECs in a comparison between the OPCS and OC groups showed that genes involved in mitogen-activated protein kinase signaling were the most common. Results of functional analyses of DECs in an OC vs. OC + AL comparison were similar to those in the OPCS vs. OC comparison. Finally, qPCR showed that, in the OC + AL vs. OC group comparison, the expression levels of seven and three DECs significantly decreased and increased, respectively. Conclusions Having successfully induced OPCSs to differentiate into OCs, we showed that AL suppresses the differentiation of OPCS into OC and that 10 DECs were involved in the regulation of this process. This indicates that these DECs might be important to the treatment of OP. </jats:sec

A Flexible Interconnected Distribution Network Power Supply Restoration Method Based on E-SOP

To enhance the self-healing control capability of soft open points with energy storage (E-SOPs) and optimize the fault recovery performance in flexible interconnected distribution networks, this paper proposes a novel power supply restoration method based on E-SOP. The methodology begins with a comprehensive analysis of the E-SOP&rsquo;s fundamental architecture and loss model. Subsequently, a dual-objective optimization function is formulated to maximize the sum of nodal active load restoration while minimizing network losses. The optimization problem is transformed into a second-order cone programming formulation under comprehensive operational constraints. To solve this complex optimization model, an innovative hybrid approach combining the Improved Whale Optimization Algorithm (IWOA) with second-order cone programming is developed. The proposed methodology is extensively validated using the IEEE 33-node test system. The experimental results demonstrate that this approach significantly enhances the power supply restoration capability of distribution networks while maintaining practical feasibility

Internal fixation of acetabular fractures in an older population using the lateral-rectus approach: short-term outcomes of a retrospective study

Abstract Purpose This study aims to examine the clinical efficacy and surgical techniques of the lateral-rectus approach for treatment of acetabular factures in elderly patients. Methods After appropriate exclusion, 65 elderly patients with an acetabular fracture who was treated through the lateral-rectus approach from January 2011 and October 2016 were selected retrospectively. By analyzing the medical records retrospectively, the patients’ characteristics, fracture type, mechanism of injury, comorbid conditions, ASA class, operative time, intra-operative blood loss, and post-operative complications were assessed. Clinical examination radiographs have been taken, align with the Matta evaluation system. Functional outcomes were evaluated using surveys including SF-36, Harris hip score, and modified Merle D’Aubigne-Postel. Results All 65 patients had undergone the single lateral-rectus approach successfully. Surgery duration was 101.23 min on average (45–210), and intra-operative bleeding was 798.46 ml on average (250–1800). According to the Matta radiological evaluation, the quality of reduction evaluated 1 week after surgery was rated as “anatomical” in 41 (63.1%) cases, “imperfect” in 12 (18.5%) cases, and “poor” in 12 (18.5%) cases. The modified Merle D’Aubigne-Postel score performed 18 months after surgery was categorized as excellent in 40 (61.5%) cases, good in 10 (15.4%) cases, and fair in 15 (23.1%) cases. The mean Harris Hip score was similar as present researches, being 87.18. The mean SF-36 score was 69.12 which was considered as normal for the group age 60 and older. Several complications were found, including screw loosening in 10 cases, fat liquefaction of incision in 2 cases, deep vein thrombosis in 2 cases, and temporary weakness of hip adductors in 5 cases. None of the patients had heterotopic ossification. Conclusions The lateral-rectus approach is a valuable alternative to the ilioinguinal and modified Stoppa approach, being the treatment of acetabular fractures in elderly patients

Mechanisms of asiaticoside in keloid treatment: Insights from a single-cell transcriptomic approach combined with network pharmacological analysis

This work sought to clarify the molecular processes through which asiaticoside operates in treating keloid by utilizing an integrated approach employing scRNA-seq and systems pharmacological methods. We performed scRNA-seq on three patients' keloid and adjacent normal skin samples. We detected 1500 highly variable genes and further examined them using PCA and tSNE techniques. Drug targets of asiaticoside were predicted through multiple databases, and overlapping genes with keloid-related cell types (macrophages and keloid fibroblasts (KFs)) were analyzed. GO and KEGG enrichment evaluations were performed, followed by in vitro assays to confirm the influence of asiaticoside on macrophage and keloid fibroblast. scRNA-seq revealed significant cellular heterogeneity between keloid and adjacent tissue, with macrophages and KFs identified as major contributors to its pathogenesis. Network pharmacology identified NF-κB, PI3K-Akt signaling, etc., through which asiaticoside exerts its anti-inflammatory and anti-fibrotic effects. In vitro studies confirmed that asiaticoside inhibited macrophage activation and reduced the pro-fibrotic effects of macrophage on KF. Our study demonstrates asiaticoside alleviates keloid by modulating macrophage function and KF activity through NF-κB and PI3K-Akt signaling. These findings provide a novel mechanistic understanding of asiaticoside’s therapeutic effects and offer insights into its clinical application