Türk Toplumunda İlk Hemoglobin Kansas [?102(G4)Asn?Thr, AAC>ACC] Gözlemi]

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Ferric Carboxymaltose as Treatment in Women with Iron-Deficiency Anemia

Objective. To evaluate safety and efficacy of intravenous ferric carboxymaltose (FCM) versus standard medical care (SMC) for iron-deficiency anemia (IDA) in postpartum women and women with heavy menstrual bleeding. Study Design. This open-label, multicenter study randomized women with IDA (hemoglobin ≤ 11.0 g/dL) to single doses of FCM (15 mg/kg [maximum 1000 mg]) or SMC (this treatment was determined by the investigator and there may have been no treatment). Safety data (primary outcome) were collected for 30 days. Results. Of 2045 subjects enrolled (FCM: = 1023; SMC: = 1022), 996 received FCM and 1022 received SMC. At least 1 serious adverse event (AE) was reported by 0.6% and 2.2% of subjects in the FCM and SMC groups, respectively; none were considered treatment related. The difference in serious AEs was primarily due to higher rates of uterine leiomyoma, uterine hemorrhage, and menorrhagia in SMC subjects with heavy menstrual bleeding. Common AEs were generally predictable, with higher rates of infusion site reactions in FCM subjects and gastrointestinal AEs in SMC subjects. Mean hemoglobin increases were greater in the FCM group than the SMC group. Conclusion. FCM was well tolerated and effectively increased mean hemoglobin levels in postpartum women or women with heavy menstrual bleeding and IDA. This trial is registered with ClinicalTrials.gov, NCT00548860

Hemoglobinopatilerde Covid19

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Welcome Messages

On behalf of the Turkish Federation of Thalassaemia (TFT) [...

Welcome messages

Dear Participants,On behalf of the Turkish Federation of Thalassaemia (TFT), we are honoured to invite you to the 12th International Conference on Thalassaemia and the Haemoglobinopathies and the 14th International Conference for Patients and Parents, which will be held in Antalya, Turkey in May 2011...&nbsp;On behalf of the Board of Directors of the Thalassaemia International Federation (TIF), I would like to extend a warm invitation to you to attend the 12th International Conference on Thalassaemia and Other Haemoglobinopathies, and the 14th TIF Conference for Patients and Parents, to be held on 11&ndash;15 May in Antalya, Turkey...</p

SALIVA IRON AND FERRITIN LEVELS IN PATIENTS WITH THALASSEMIA AND IRON DEFICIENCY ANEMIA

&lt;p&gt;Most of the  techniques for measuring iron accumulation such as serum iron concentration, iron binding capacity, serum ferritin level, liver biopsy are invasive and hard methods for patients. The changes in trace element concentrations in saliva at different systemic diseases shows the quantity of the element at the body. The aim of this study was to compare the levels of iron and ferritin in saliva and serum in patients  with thalassemia and iron deficiency anemia. For this purpose, 35 healthy children as control group and 71 thalassemia major, 10 thalassemia intermedia and 15 thalassemia trait patients were involved. Their saliva  and serum iron and ferritin levels were measured.  There was no statistically difference between age and gender in all groups and control group (p&amp;gt;0.05).  In all groups saliva iron levels are higher than serum iron levels(p&amp;lt;0.05). Furthermore there was a positive correlation betwen serum and saliva  iron levels in thalassemia major, intermedia and trait groups ( p=0.000, r=0.972, r=0.720, r=0.955) and also there was a positive correlation between serum and saliva iron levels in control and iron deficiency group (p= 0.000, r= 0.885, r= 0.368).  In conclusion,  Saliva iron and ferritin levels increase  as well as serum in patients with thalassemia and decrease in patients with iron deficiency anemia. Saliva can be used for diagnosis routinely  to shows the iron overload  and deficiency of the body and its easy applicability and also a non-invasive procedure is important advantage.&lt;/p&gt

12th International Conference on Thalassemia and the Haemoglobinopathies, 11–14 May 2011, Antalya, Turkey

Thalassemia is one of the common genetic disorders [...