The effects of supplemental melatonin administration on the healing of bone defects in streptozotocin-induced diabetic rats

Diabetes mellitus (DM) causes an increased production of free radicals that can impair bone healing. Melatonin is a hormone secreted mainly by the pineal gland, which participates in the neutralization process of free radicals. Objective The aim of this study was to investigate histologic and biochemical effects of supplemental melatonin administration on bone healing and antioxidant defense mechanism in diabetic rats. Material and Methods Eighty-six Sprague-Dawley male rats were used in this study. Diabetes mellitus was induced by intraperitoneal (i.p.) administration of 65 mg/kg streptozotocin (STZ). Surgical bone defects were prepared in the tibia of each animal. Diabetic animals and those in control groups were treated either with daily melatonin (250 μg/animal/day/i.p.) diluted in ethanol, only ethanol, or sterile saline solution. Rats were humanely killed at the 10th and 30th postoperative days. Plasma levels of Advanced Oxidation Protein Products (AOPP), Malondialdehyde (MDA), and Superoxide Dismutase (SOD) were measured. The number of osteoblasts, blood vessels and the area of new mineralized tissue formation were calculated in histologic sections. Results At the 10th day, DM+MEL (rats receiving both STZ and melatonin) group had significantly higher number of osteoblasts and blood vessels as well as larger new mineralized tissue surfaces (

Effect of calcium hydroxide and combinations of ledermix and calcium hydroxide on inflamed pulp in dog teeth

The effects of Ledermix + calcium hydroxide (Ca(OH)(2)) or Ca(OH)(2) alone on inflamed pulp tissues of dogs were studied, Fifty-nine upper incisor teeth of 10 dogs were used, Class V cavities were prepared and filled with amalgam after placement of decayed dentin particles. After 7 days, the decayed dentin and alloy were removed, and the pulps of the teeth were exposed, Ledermix and Ca(OH)(2) mixtures or Ca(OH)(2) atone were applied to the cavities

Odontogenic and nonodontogenic cysts in Istanbul: Analysis of 5088 cases

Background The aim of this study was to determine the prevalence of 5088 odontogenic and nonodontogenic cysts over a 40-year period in the Turkish population and to compare results with findings in the literature. Methods The records of odontogenic and nonodontogenic cysts, occurring during 1971 to 2010, were collected and analyzed for anatomic site, age range, and sex distribution. Results Among 5088 odontogenic and nonodontogenic cyst biopsies, 5003 cases (98.3%) were classified as odontogenic, whereas only 85 cases (1.7%) were nonodontogenic. In the former group, the most frequent diagnosis was radicular cyst (52.09%), followed by odontogenic keratocyst (20.6%) and dentigerous cyst (10.39%). Maxilla to mandible ratio was 1.13:1. The mean age of patients was 36.33 years (range, 287 years). The cysts were slightly more prevalent among male patients (57.70%). Conclusions The knowledge of the biological behavior and clinicopathologic features of jaw cysts constitute key aspects to provide early diagnosis and adequate surgery. (c) 2011 Wiley Periodicals, Inc. Head Neck, 201