Prediksi Angin Menggunakan Data Temperatur, Kelembaban, Curah Hujan, Penyinaran Matahari dengan Metode ANN (Artificial Neural Network) (Studi Kasus Perairan Pulau Bintan): Wind Prediction Using Data of Temperature, Humidity, Rainfall, Solar Radiance with the ANN (Artificial Neural Network) Method (Case Study of Bintan Island Waters)

Kebutuhan akan prediksi sangat diperlukan pada berbagai sektor kehidupan, salah satunya adalah mengenai prediksi kecepatan dan arah angin. Prediksi mengenai kecepatan dan arah angin dalam penelitian ini dilaksanakan dengan menggunakan Artificial Neural Network. Data yang digunakan adalah data harian BMKG Tanjung Pinang, Pulau Bintan selama 10 Tahun dengan menggunakan 5 parameter yaitu temperatur maksimum, temperatur rata-rata, kelembapan rata-rata, curah hujan, dan lamanya penyinaran matahari yang kemudian disebut sebagai predictor selanjutnya parameter kecepatan serta arah angin yang kemudian disebut sebagai predictand. Dari hasil prediksi diperoleh bahwa model ANN dapat memberikan hasil arah dengan akurasi 73% sampai dengan 83%. Sementara prediksi kecepatan angin dengan model ANN memberikan akurasi sebesar 77% sampai dengan 95%

Prediksi Angin Menggunakan Data Temperatur, Kelembaban, Curah Hujan, Penyinaran Matahari Dengan Metode ANN (Artificial Neural Network) (Studi Kasus: Perairan Pulau Bintan)

Kebutuhan akan prediksi sangat diperlukan pada berbagai sektor kehidupan, salah satunya adalah mengenai prediksi kecepatan dan arah angin. Prediksi mengenai kecepatan dan arah angin dalam penelitian ini dilaksanakan dengan menggunakan Artificial Neural Network. Data yang digunakan adalah data harian BMKG Tanjung Pinang, Pulau Bintan selama 10 Tahun dengan menggunakan 5 parameter yaitu temperatur maksimum, temperatur rata-rata, kelembaban rata-rata, curah hujan, dan lamanya penyinaran matahari yang kemudian disebut sebagai predictor selanjutnya parameter kecepatan serta arah angin yang kemudian disebut sebagai predictand. Dari hasil prediksi diperoleh bahwa model ANN dapat memberikan hasil arah dengan akurasi 73% sampai dengan 83%. Sementara prediksi kecepatan angin dengan model ANN memberikan akurasi sebesar 77% sampai dengan 95%

Nucleophilic opening of the 3,5-anhydro ring in 1,2-O-cyclohexylidene-a-D-xylofuranose

The reactivity of the oxetane ring in 3,5-anhydro-1,2-O-cyclohexylidene-a-D-xylofuranose (1) was exemplified by its regiospecific nucleophilic opening. The action of concentrated hydrobromic or hydroiodic acid on 1 resulted in the exclusive formation of the 5-deoxy-5-halo derivatives, while the action of acetyl chloride or acetyl bromide yielded the corresponding 3-O-acetyl-5-deoxy-5-halo derivatives in 70 90 % yield. Under strongly acidic reaction conditions, the protection of the cyclohexylidene acetal function remained intact

An improved synthesis for obtaining 2-deoxy-2-iodo-D-mannopyranose derivatives

The aim of this work was to synthesize 2-deoxy-2-iodo-manno sugars and 2-deoxy-2-iodo manno esters of a satisfactory purity in the highest possible yield. For this put-pose, the iodination reaction of D-glucal triacetate (1), 3,4-di-O-acetyl-6-O-to-syl-D-glucal (2) and 3,4-di-O-acetyl-6-S-acetyl-6-thio-D-glucal (3) were investigated using a mixture of NaIO4-NaI at pH 6 (acetate buffer) and pH 7 (phosphate buffer) in a tert-butanol-water solvent system. Depending on the buffer system used, a mixture of the 2-deoxy-2-iodo-manno esters 4, 6 or 8 together with corresponding 2-deoxy-2-iodo sugars 5, 7, or 9 were obtained, or separately

An improved synthesis for obtaining 2-deoxy-2-iodo-D-mannopyranose derivatives

The aim of this work was to synthesize 2-deoxy-2-iodo-manno sugars and 2-deoxy-2-iodo manno esters of a satisfactory purity in the highest possible yield. For this put-pose, the iodination reaction of D-glucal triacetate (1), 3,4-di-O-acetyl-6-O-to-syl-D-glucal (2) and 3,4-di-O-acetyl-6-S-acetyl-6-thio-D-glucal (3) were investigated using a mixture of NaIO4-NaI at pH 6 (acetate buffer) and pH 7 (phosphate buffer) in a tert-butanol-water solvent system. Depending on the buffer system used, a mixture of the 2-deoxy-2-iodo-manno esters 4, 6 or 8 together with corresponding 2-deoxy-2-iodo sugars 5, 7, or 9 were obtained, or separately

Effect of substituents on the C-13 NMR chemical shifts of para-substituted alpha-phenyl-beta-pyridylacrylic acids

The C-13 NMR spectra of para-substituted alpha-phenylcinnamic and 3- and 4-pyridylacrylic acids, with a wide range of substituents effects, were determined in deuterated dimethylsulfoxide (DMSO-d(6)). The effect of substituents in both the alpha-phenyl and beta-pyridine groups in these acids is investigated using linear free energy relationships and multiple regression analysis as applied to C-13 NMR chemical shifts of the C-alpha and C-beta of the ethylenic bond and the carboxylic group carbon. Dissection of the alpha-phenyl substituent effects into the inductive and resonance components, using the dual substituent parameter (DSP) method, points to a blend of inductive and resonance effects in the pi-electronic system

Pharmacokinetics of Serelaxin in Patients with Severe Renal Impairment or End-Stage Renal Disease Requiring Hemodialysis: A Single-dose, Open-label, Parallel-group Study

Serelaxin, a recombinant human relaxin-2, is currently in clinical development for treating acute heart failure. This open-label parallel-group study investigated serelaxin pharmacokinetics (PK) after a single 4-h intravenous infusion (10μg/kg) in patients with severe renal impairment (n=6) or end-stage renal disease (ESRD) requiring hemodialysis (with PK on the day of dialysis [n=6] or during dialysis-free interval [n=6]) compared with healthy subjects (n=18). In all participants, serum serelaxin concentration peaked at the end of infusion and subsequently declined with a mean terminal elimination half-life of 6.5–8.8h. Compared to healthy subjects, a moderate decrease in serelaxin systemic clearance (37%–52%) and increase in its exposure (30%–115%) were observed in all patients. During the 4-h hemodialysis in ESRD patients, serelaxin was partially removed (30%) from blood with dialysis clearance constituting approximately 52% of total systemic clearance. Anti-serelaxin antibodies were not detected in any participant, and serelaxin was well tolerated with no deaths, serious adverse events (AE), or AE-related discontinuations. The observed serelaxin PK differences in patients with severe renal impairment compared with matched healthy subjects are unlikely to pose a safety risk and do not warrant a predefined dosage adjustment in such patients