Devonian operculate corals (Calceolidae, Cnidaria) from the Massif Armoricain, France

The operculate coral Calceola gervillei Bayle, 1878 is described for the first time on the basis of the type material from the Cotentin region of Normandy (North Armorican Domain), from Early Devonian (likely upper Lochkovian to lower Pragian) strata, and is chosen as the type species of the monotypic new genus Gerviphyllum. The new genus is also present in the l\u27Armorique Formation (lower Pragian) of the Plougastel Peninsula (Central Armorican Domain) as Gerviphyllum sp. cf. G. gervillei. One locality in the upper Emsian (Polygnathus serotinus Conodont Zone) Le Fret Formation, on the northern coast of the Crozon Peninsula, has yielded operculate coral specimens described here as ?Chakeola sp., the first (tentative) record of the genus outside eastern Australia, south China and Vietnam. The operculate coral Calceola collini sp. nov. is described from six localities in the early Middle Devonian (Eifelian: Polygnathus costatus Conodont Zone) Saint-Fiacre Formation of the Plougastel and Crozon Peninsulas (Central Armorican Domain), despite the fact that knowledge of the internal characters, especially of the operculum, of the type species Calceola sandalina is very limited. From an extensive review of published references to Calceola from France, we conclude that only the record of Collin (1929) is valid

ASIA syndrome, calcinosis cutis and chronic kidney disease following silicone injections. A case-based review

An immunologic adjuvant is a substance that enhances the antigen-specific immune response preferably without triggering one on its own. Silicone, a synthetic polymer used for reconstructive and cosmetic purposes, can cause, once injected, local and/or systemic reactions and trigger manifestations of autoimmunity, occasionally leading to an overt autoimmune disease. Siliconosis, calcinosis cutis with hypercalcemia and chronic kidney disease have all been reported in association with silicone injection. Here, we describe a case of autoimmune/auto-inflammatory syndrome induced by adjuvants, calcinosis cutis and chronic kidney disease after liquid silicone multiple injections in a young man who underwent a sex reassignment surgery, followed by a review of the literature. To our knowledge, this is the first report describing the concomitance of the three clinical conditions in the same patients. The link between silicone and the immune system is not completely understood yet and requires further reports and investigations with long-term data, in order to identify the main individual and genetical risk factors predisposing to the wide spectrum of the adjuvant-induced responses

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

International audienceIn 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field