In memoriam two distinguished participants of the Bregenz Symmetries in Science Symposia: Marcos Moshinsky and Yurii Fedorovich Smirnov

Some particular facets of the numerous works by Marcos Moshinsky and Yurii Fedorovich Smirnov are presented in these notes. The accent is put on some of the common interests of Yurii and Marcos in physics, theoretical chemistry, and mathematical physics. These notes also contain some more personal memories of Yurii Smirnov.Comment: Submitted for publication in Journal of Physics: Conference Serie

Supplementation with spray-dried porcine plasma in piglets at birth: effects on protein metabolism and performance.

Resumo: Este estudo foi planejado para avaliar se a suplementação de leitões com plasma sanguíneo suíno desidratado (PSSP) no dia do nascimento tem efeito positivo sobre o metabolismo proteico e ganho de peso (GP) em leitões, bem como no desempenho na fase de creche. Selecionamos 30 leitegadas de marrãs, das quais, no mínimo um casal de leitões para cada tratamento/leitegada foi selecionado. Os tratamentos foram: TA = controle sem PSSP, TB = administração oral de 10 g de PSSP e TC = 20 g de PSSP. No nascimento, os leitões foram pesados, identificados e distribuídos aleatoriamente. Os pesos corporais também foram avaliados nos dias 7, 14 e 19. Foram coletadas amostras de sangue para medir o nível de uréia, proteína total (PT), albumina (AB) e globulina (GB). No desmame, 70 leitões de cada tratamento foram distribuídos em cinco grupos (réplicas) de 14 leitões (sete machos e sete fêmeas). Os dados de pesos (animais e consumo de ração) foram coletados no pós-desmame e também a cada troca de dieta (dias 14, 28 e 42 da fase de creche). Durante as duas primeiras semanas na maternidade, não houve efeitos dos tratamentos para todas as variáveis avaliadas. Na terceira semana, os leitões de TC apresentaram níveis séricos mais altos para as variáveis PT e GB, mas o GT foi menor nos leitões comparado ao controle. Não houve efeito dos tratamentos no GT durante todo o período lactente. Não houve efeitos residuais no desempenho da fase de creche; no entanto, os leitões tratados tiveram menos necessidade de medicamentos. A suplementação com PSSP não influenciou o desempenho zootécnico nas duas primeiras semanas ou durante todo o período lactente. O grupo TC apresentou níveis mais altos de globulina do que o grupo TA. Na fase de creche, não houve efeitos no desempenho; no entanto, houve uma maior incidência de animais doentes do grupo TA. Abstract: This research was designed to evaluate whether supplementation of piglets with spray dried porcine plasma (SDPP) on the day of birth, have positive effect on protein metabolism and weight gain (WG) in suckling piglets, as well as on performance at the nursery phase. We selected 30 litters from gilts of at least one pair of piglets for each treatment, TA= control without SDPP, TB= oral administration of 10 g of SDPP, and TC= 20 g of SDPP. At birth, the piglets were weighed, identified and randomly distributed. Body weights were also measured on days 7, 14 and 19. Blood samples were collected to measure the level of urea, total protein (TP), albumin (AB) and globulin (GB). At weaning, 70 piglets from each treatment were distributed in five groups (replicates) of 14 piglets (seven males and seven females). Weights (animals and feed intake) were taken at post-weaning and at each feed change (days 14, 28 and 42 of raising). During the first two weeks of lactation, there were no effects of the treatments for the all evaluated variables. In the third week, TC piglets had higher serum levels of TP and GB, but lower WG than did control piglets. There was no effect of treatments on WG during the entire suckling period. There were no residual effects on nursery phase performance; however, treated piglets had less need for medications. SDPP supplementation did not influence zootechnical performance in the first two weeks or during the entire suckling period. The TC group had higher globulin levels than did the TA group. In the weaning phase, there were no effects on performance; however, there was a higher incidence of diseased animals in the TA group. Resumen: Este estudio fue diseñado para evaluar si la suplementación de lechones con plasma porcino secado por atomización (PPSA) el día del nacimiento, tiene un efecto positivo sobre el metabolismo de las proteínas y el aumento de peso (AP) en lechones lactantes, así como el rendimiento en la fase de cría. Seleccionamos 30 camadas de marranas al menos un par de lechones para cada tratamiento: TA = control sin PPSA, TB = administración oral de 10 g de PPSA y TC = 20 g de PPSA. Al nacer, los lechones fueron pesados, identificados y distribuidos al azar. Los pesos corporales también se midieron los días 7, 14 y 19. Se recogieron muestras de sangre para medir el nivel de urea, proteína total (PT), albúmina (AB) y globulina (GB). Al destete, se distribuyeron 70 lechones de cada tratamiento en cinco grupos (réplicas) de 14 lechones (siete machos y siete hembras). Los pesos (animales y consumo de alimento) se tomaron después del destete y en cada cambio de alimento (días 14, 28 y 42 de crianza). Durante las primeras dos semanas de lactancia, no hubo efectos de los tratamientos para todas las variables evaluadas. En la tercera semana, los lechones TC tenían niveles séricos más altos de TP y GB, pero un AP más bajo que los lechones de control. No hubo efecto de los tratamientos sobre el AP durante todo el período de lactancia. No hubo efectos residuales en el rendimiento de la fase de vivero; sin embargo, los lechones tratados tenían menos necesidad de medicamentos. La suplementación con SDPP no influyó en el rendimiento zootécnico en las primeras dos semanas o durante todo el período de lactancia. El grupo TC tenía niveles de globulina más altos que el grupo TA. En la fase de destete, no hubo efectos en el rendimiento; sin embargo, hubo una mayor incidencia de animales enfermos en el grupo TA

Phase I, open-label study of pasireotide in patients with <i>BRAF-</i>wild type and <i>NRAS</i>-wild type, unresectable and/or metastatic melanoma.

Somatostatin analogues exert antitumour activity via direct and indirect mechanisms. The present study was designed to assess the safety and efficacy of pasireotide in patients with &lt;i&gt;BRAF&lt;/i&gt; -wild type (WT) and &lt;i&gt;NRAS&lt;/i&gt; -WT metastatic melanoma. Patients with unresectable and/or metastatic melanoma or Merkel cell carcinoma were eligible. Pasireotide was administered at different doses for ≤8 weeks in dose-escalation phase, followed by long-acting pasireotide 80 mg or lower dose in case of toxicity in follow-up phase up to six additional months. Primary endpoint was safety in the first 8 weeks of dose-escalation phase. The study was terminated early due to slow recruitment. Of the 10 patients with metastatic melanoma enrolled, only four reached the high dose level: two patients reached 3600 µg in dose-escalation and follow-up phases and two patients reached 3600 µg in dose-escalation and long-acting pasireotide 80 mg in follow-up phases and were stable for &gt;5 months. Most common adverse events (AEs) during dose-escalation phase in ≥2 patients (20%) were: diarrhoea (50%), nausea (50%), fatigue (20%), hyperglycaemia (20%), hypophosphatemia (20%), chills (20%) and tumour pain (20%). Grade 3 or 4 study drug-related AEs were diarrhoea and nausea, reported in one patient. Partial response was documented in one patient and stable disease in another. Pasireotide was well tolerated, and safety results were similar to those previously reported in other indications. Further studies are needed to evaluate its antitumour activity alone and in combination with other drugs in melanoma

Maximizing the general success of cecal intubation during propofol sedation in a multi-endoscopist academic centre

<p>Abstract</p> <p>Background</p> <p>Achieving the target of 95% colonoscopy completion rate at centres conducting colorectal screening programs is an important issue. Large centres and teaching hospitals employing endoscopists with different levels of training and expertise risk achieving worse results. Deep sedation with propofol in routine colonoscopy could maximize the results of cecal intubation.</p> <p>Methods</p> <p>The present study on the experience of a single centre focused on estimating the overall completion rate of colonoscopies performed under routine propofol sedation at a large teaching hospital with many operators involved, and on assessing the factors that influence the success rate of the procedure and how to improve this performance, analyzing the aspects relating to using of deep sedation. Twenty-one endoscopists, classified by their level of specialization in colonoscopic practice, performed 1381 colonoscopies under deep sedation. All actions needed for the anaesthesiologist to restore adequate oxygenation or hemodynamics, even for transient changes, were recorded.</p> <p>Results</p> <p>The "crude" overall completion rate was 93.3%. This finding shows that with routine deep sedation, the colonoscopy completion rate nears, but still does not reach, the target performance for colonoscopic screening programs, at centers where colonoscopists of difference experience are employed in such programs.</p> <p>Factors interfering with cecal intubation were: inadequate colon cleansing, endoscopists' expertise in colonoscopic practice, patients' body weight under 60 kg or age over 71 years, and the need for active intervention by the anaesthesiologist. The most favourable situation - a patient less than 71 years old with a body weight over 60 kg, an adequate bowel preparation, a "highly experienced specialist" performing the test, and no need for active anaesthesiological intervention during the procedure - coincided with a 98.8% probability of the colonoscopy being completed.</p> <p>Conclusions</p> <p>With routine deep sedation, the colonoscopy completion rate nears the target performance for colonoscopic screening programs, at centers where colonoscopists of difference experience are employed in such programs. Organizing the daily workload to prevent negative factors affecting the success rate from occurring in combination may enable up to 85% of incomplete procedures to be converted into successful colonoscopies.</p

Mal di montagna in Idoneità pneumologica per l’attività sportiva

In questo capitolo viene affrontato dell,idoneità pneumologica per l'attività sportiva svolta in alta quota in relazione all'eventualità del manifestarsi del mal di montagna

Ventilazione ed esercizio

Relazione tra esercizio fisico e ventilazione .Descrizione del pattern ventilatorio e del lavoro della mucolatura respiratoria durante esercizio

Long-term (1-year) effects of two methods of exercise training (ET) in COPD patients

Introduction: the success of long-term ET programs resides in the integration between exercise prescription and patients' compliance with home training. Aim: to evaluate two methods to help understanding and maintaining the exercise (walking) intensity. Methods: 36 COPD patients (9F,27M) participated to the ET program (age 72 ±8; FEV1% 48±12). T0= first evaluation: 6MWD, tests on treadmill to evaluate walking distance covered in twenty minutes (20MWD) and maximal speed, monitoring of physical activity (Armband). Patients were then divided in 2 groups for the home ET program: A1= speed walking marked by a metronome; A2=covering a known distance in a fixed time. Test were repeated after 5 and 12 months (T5;T12). Control group: 23 well matched COPD not partecipating in ET (8F,15M,age 69±7,FEV1% 52±11) Results: Group A1-A2. Daily METs Physical activity > 3 METs (hours) 6MWD (m) Max speed (Km/h) 20MWD (m) A1 T0 1,22±0,13 0,39±0,38 299±87 3,7±1,1 790±292 A2 T0 1,29±0,21 0,66±0,56 261±94 3,6±1,2 726±250 A1 T5 1,31±0,16* 0,95±0,86* n.a. 4,0±1,2* 970±363* A2 T5 1,36±0,22* 1,11±0,77* n.a. 3,9±0,3 868±334* A1 T12 1,39±0,16*^ 0,96±0,64* 369±80* 4,5±1,2*^ 1028±335*^ A2 T12 1,33±0,25 0,97±0,67^ 315±92* 4,2±1,4* 840±320* * vs T0 ; ^ vs T5 Control group: no significant change.Conclusions: ET performed at a metronome-marked speed allows the patient to better understand the intensity of exercise and is more effective with time, as shown by the mantaining of higher physical activity and performance after 12 months in A1 compared to A2. ^*=p<0,0

Recursion relations for Clebsch-Gordan coefficients of Uq_{q}(su2_{2}) and Uq_{q}(su1,1_{1,1})

International audienceWe report in this article three- and four-term recursion relations for Clebsch-Gordan coefficients of the quantum algebras U_q(su_2) and U_q(su_{1,1}). These relations were obtained by exploiting the complementarity of three quantum algebras in a q-deformation of sp(8, \gr)