16,628 research outputs found

    Lubrication handbook

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    Information on lubricants from government reports, military specifications, qualified parts lists, and suppliers of commercial lubricants has been consolidated in one source. Handbook includes data on chemical and physical properties of solid, bonded solid, and liquid lubricants; dispersions and composites; and greases, oils, and hydraulic fluids

    Predicting the Equity Premium Out of Sample: Can Anything Beat the Historical Average?

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    A number of variables are correlated with subsequent returns on the aggregate US stock market in the 20th Century. Some of these variables are stock market valuation ratios, others reflect patterns in corporate finance or the levels of shortand long-term interest rates. Amit Goyal and Ivo Welch (2004) have argued that in-sample correlations conceal a systematic failure of these variables out of sample: None are able to beat a simple forecast based on the historical average stock return. In this note we show that forecasting variables with significant forecasting power insample generally have a better out-of-sample performance than a forecast based on the historical average return, once sensible restrictions are imposed on the signs of coefficients and return forecasts. The out-of-sample predictive power is small, but we find that it is economically meaningful. We also show that a variable is quite likely to have poor out-of-sample performance for an extended period of time even when the variable genuinely predicts returns with a stable coefficient.

    Government as a social machine - the implications of government as a social machine for making and implementing market-based policy

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    This is the second of two reports from the Government as a Social Machine project. The first report gave an overview of the evolution of electronic/digital government, and explored the concept of 21st century government as a \u27social machine\u27. This report identifies seven social machines developed by governments in Australia and New Zealand. These social machines harness digital technologies in order to deliver more effective and efficient services, develop better business practices, and enable better accountability and transparency. The report gives an overview of each social machine in context, describing the social need that is being met and the community that has developed it, and begins to unravel some of the socio-political consequences that might arise from the use of these social machines within the public policy context. These reports are not intended to be comprehensive (further educational materials are being developed as part of the ANZSOG Case Library), but they are intended to begin a conversation amongst those studying or practicing in public policy as to how governments can better understand, manage and employ these evolving social machines for better governance and social benefit

    The credibility of health economic models for health policy decision-making: the case of population screening for abdominal aortic aneurysm

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    <i>Objectives</i>: To review health economic models of population screening for abdominal aortic aneurysm (AAA) among elderly males and assess their credibility for informing decision-making. <i>Methods</i>: A literature review identified health economic models of ultrasound screening for AAA. For each model focussing on population screening in elderly males, model structure and input parameter values were critically appraised using published good practice guidelines for decision analytic models. <i>Results</i>: Twelve models published between 1989 and 2003 were identified. Converting costs to a common currency and base year, substantial variability in cost-effectiveness results were revealed. Appraisals carried out for the nine models focusing on population screening showed differences in their complexity, with the simpler models generating results most favourable to screening. Eight of the nine models incorporated two or more simplifying structural assumptions favouring screening; uncertainty surrounding these assumptions was not investigated by any model. Quality assessments on a small number of parameters revealed input values varied between models, methods used to identify and incorporate input data were often not described, and few sensitivity analyses were reported. <i>Conclusions</i>: Large variation exists in the cost-effectiveness results generated by AAA screening models. The substantial number of factors potentially contributing to such disparities means that reconciliation of model results is impossible. In addition, poor reporting of methods makes it difficult to identify the most plausible and thus most useful model of those developed

    Estimating Lunar Pyroclastic Deposit Depth from Imaging Radar Data: Applications to Lunar Resource Assessment

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    Lunar pyroclastic deposits represent one of the primary anticipated sources of raw materials for future human settlements. These deposits are fine-grained volcanic debris layers produced by explosive volcanism contemporaneous with the early stage of mare infilling. There are several large regional pyroclastic units on the Moon (for example, the Aristarchus Plateau, Rima Bode, and Sulpicius Gallus formations), and numerous localized examples, which often occur as dark-halo deposits around endogenic craters (such as in the floor of Alphonsus Crater). Several regional pyroclastic deposits were studied with spectral reflectance techniques: the Aristarchus Plateau materials were found to be a relatively homogeneous blanket of iron-rich glasses. One such deposit was sampled at the Apollo 17 landing site, and was found to have ferrous oxide and titanium dioxide contents of 12 percent and 5 percent, respectively. While the areal extent of these deposits is relatively well defined from orbital photographs, their depths have been constrained only by a few studies of partially filled impact craters and by imaging radar data. A model for radar backscatter from mantled units applicable to both 70-cm and 12.6-cm wavelength radar data is presented. Depth estimates from such radar observations may be useful in planning future utilization of lunar pyroclastic deposits

    Marked expansion of exocrine and endocrine pancreas with incretin therapy in humans with increased exocrine pancreas dysplasia and the potential for glucagon-producing neuroendocrine tumors.

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    Controversy exists regarding the potential regenerative influences of incretin therapy on pancreatic β-cells versus possible adverse pancreatic proliferative effects. Examination of pancreata from age-matched organ donors with type 2 diabetes mellitus (DM) treated by incretin therapy (n = 8) or other therapy (n = 12) and nondiabetic control subjects (n = 14) reveals an ∼40% increased pancreatic mass in DM treated with incretin therapy, with both increased exocrine cell proliferation (P < 0.0001) and dysplasia (increased pancreatic intraepithelial neoplasia, P < 0.01). Pancreata in DM treated with incretin therapy were notable for α-cell hyperplasia and glucagon-expressing microadenomas (3 of 8) and a neuroendocrine tumor. β-Cell mass was reduced by ∼60% in those with DM, yet a sixfold increase was observed in incretin-treated subjects, although DM persisted. Endocrine cells costaining for insulin and glucagon were increased in DM compared with non-DM control subjects (P < 0.05) and markedly further increased by incretin therapy (P < 0.05). In conclusion, incretin therapy in humans resulted in a marked expansion of the exocrine and endocrine pancreatic compartments, the former being accompanied by increased proliferation and dysplasia and the latter by α-cell hyperplasia with the potential for evolution into neuroendocrine tumors
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