La lutte contre les schistosomoses en Afrique de l'Ouest

Le document présenté ici constitue la révision du score défini par l'atelier du Caire et mis à jour en octobre 1996 lors de l'atelier de Niamey. Le score est individuel mais il permet d'évaluer le niveau de morbidité d'une population, donc de mesurer la sévérité de la schistosomose pour déterminer la conduite à tenir. (Résumé d'auteur

A new design for the CERN-Fr\'ejus neutrino Super Beam

We present an optimization of the hadron focusing system for a low-energy high-intensity conventional neutrino beam (Super-Beam) proposed on the basis of the HP-SPL at CERN with a beam power of 4 MW and an energy of 4.5 GeV. The far detector would be a 440 kton Water Cherenkov detector (MEMPHYS) located at a baseline of 130 km in the Fr\'ejus site. The neutrino fluxes simulation relies on a new GEANT4 based simulation coupled with an optimization algorithm based on the maximization of the sensitivity limit on the $\theta_{13}$ mixing angle. A new configuration adopting a multiple horn system with solid targets is proposed which improves the sensitivity to $\theta_{13}$ and the CP violating phase $\delta_{CP}$.Comment: 11 pages, 18 figures, 2 table

PARISROC, a Photomultiplier Array Integrated Read Out Chip

PARISROC is a complete read out chip, in AMS SiGe 0.35 !m technology, for photomultipliers array. It allows triggerless acquisition for next generation neutrino experiments and it belongs to an R&D program funded by the French national agency for research (ANR) called PMm2: ?Innovative electronics for photodetectors array used in High Energy Physics and Astroparticles? (ref.ANR-06-BLAN-0186). The ASIC (Application Specific Integrated Circuit) integrates 16 independent and auto triggered channels with variable gain and provides charge and time measurement by a Wilkinson ADC (Analog to Digital Converter) and a 24-bit Counter. The charge measurement should be performed from 1 up to 300 photo- electrons (p.e.) with a good linearity. The time measurement allowed to a coarse time with a 24-bit counter at 10 MHz and a fine time on a 100ns ramp to achieve a resolution of 1 ns. The ASIC sends out only the relevant data through network cables to the central data storage. This paper describes the front-end electronics ASIC called PARISROC.Comment: IEEE Nuclear Science Symposium an Medical Imaging Conference (2009 NSS/MIC

GPCR-OKB: the G protein coupled receptor oligomer knowledge base

Rapid expansion of available data about G Protein Coupled Receptor (GPCR) dimers/oligomers over the past few years requires an effective system to organize this information electronically. Based on an ontology derived from a community dialog involving colleagues using experimental and computational methodologies, we developed the GPCR-Oligomerization Knowledge Base (GPCR-OKB). GPCR-OKB is a system that supports browsing and searching for GPCR oligomer data. Such data were manually derived from the literature. While focused on GPCR oligomers, GPCR-OKB is seamlessly connected to GPCRDB, facilitating the correlation of information about GPCR protomers and oligomers

Sea ice and biological production variability reconstructed in the Adélie Basin, East Antarctica, during the late Holocene

第3回極域科学シンポジウム　横断セッション「海・陸・氷床から探る後期新生代の南極寒冷圏環境変動」11月26日（月）、27日（火） ２階ラウン

Neutrino oscillations and the effect of the finite lifetime of the neutrino source

We consider a neutrino source at rest and discuss a condition for the existence of neutrino oscillations which derives from the finite lifetime $\tau_S$ of the neutrino source particle. This condition is present if the neutrino source is a free particle such that its wave function is non-stationary. For a Gaussian wave function and with some simplifying assumptions, we study the modification of the usual oscillation probability stemming from $\tau_S$. In the present accelerator experiments the effect of $\tau_S$ can be neglected. We discuss some experimental situations where the source lifetime becomes relevant in the oscillation formula.Comment: 13 pages latex file with 2 figure

The past : a compass for future earth

Antarctic sea ice impacts on the ocean-atmosphere heat and gas fluxes, the formation of deep and intermediate waters, the nutrient distribution and primary productivity, the so-called &#8216;biological carbon pump&#8217;, one of the most active in the global ocean. In this study, we explore the link between sea ice dynamic, biological production and nutrient cycling during the late Holocene (the last 2,000 yrs) in the Adélie Basin, East Antarctica, from the well-dated sediments of the Ocean Drilling Program (ODP) Site U1357. This archive, composed from ~32 meters of seasonal to annual laminated diatomaceous sequences, allows reconstructions at an unprecedented time resolution (5-10 yrs). Our study combines records of diatom census counts and diatom-specific biomarkers (a ratio (D/T) of di- and tri-unsaturated Highly Branched Isoprenoid lipids (HBI)) as indicators of sea ice and biological production changes, XRF data as markers for terrigenous inputs and bulk nitrogen isotopes (d15N) and d15N on chlorins as proxies for reconstructing nitrogen cycle. The diatom and HBI records reveal five distinct periods. From 0 to 350 yrs AD, decreasing occurrences of sea ice-related diatom species (e.g. Fragilariopsis curta + F. cylindrus) together with low D/T values and increasing open ocean diatom species (large centrics, Chaetoceros Resting Spores (CRS)) document a progressive decline of sea ice presence during the year (>9 months per year) with spring melting occurring earlier in the year and autumn sea ice formation appearing later. In contrast, between 350 and 750 yrs AD, high production of open ocean diatom species and low low D/T values and sea ice related species indicate a short duration of sea ice cover (~10 months per year) is illustrated by a pronounced increase of sea ice-associated diatom species and high D/T values. Between ~1400 and 1850 yrs AD, seasonal sea ice strongly declines (<~7 months per year) as a result of early spring melting (increasing CRS production) and late autumn waxing (high occurrences of Thalassiosira antarctica). Longer growing seasons promoted a substantial development of phytoplankton communities (especially large centric diatoms) that conducted to lower D/T values. Consistent with diatom and HBI reconstructions, XRF data show higher Fe/Al and Zr/Al ratios values during inferred warmer periods and lower ratio values during inferred cooler and icier periods, thus supporting a strong impact of the sea ice seasonal cycle on glacial runoffs. The link between sea ice conditions, biological production and nutrient cycling is still being explored and we will discuss its relationship by combining all the cited records cited above with the d15N records that we are currently generated. Based on our results, we find that sea ice dynamic and associated diatom production in the Adélie Basin revealed an opposite climatic trend than that identified in the Northern Hemisphere for the last 2000 years. The 'Little Ice Age' (1400-1850 yrs AD) or the 'Dark Ages' (400-750 yrs AD) corresponded to warmer climate conditions in the Adélie Basin, while the 'Roman Warm Period' (0-350 yrs AD) or the 'Medieval Warm Period' (900-1200 yrs AD) were associated to colder conditions. We therefore emphasize that Northern and Southern Hemisphere climate evolved in anti-phase seesaw pattern during the late Holocene

Electron neutrino tagging through tertiary lepton detection

We discuss an experimental technique aimed at tagging electron neutrinos in multi-GeV artificial sources on an event-by-event basis. It exploits in a novel manner calorimetric and tracking technologies developed in the framework of the LHC experiments and of rare kaon decay searches. The setup is suited for slow-extraction, moderate power beams and it is based on an instrumented decay tunnel equipped with tagging units that intercept secondary and tertiary leptons from the bulk of undecayed \pi^+ and protons. We show that the taggers are able to reduce the \nue contamination originating from K_e3 decays by about one order of magnitude. Only a limited suppression (~60%) is achieved for \nue produced by the decay-in-flight of muons; for low beam powers, similar performance as for K_e3 can be reached supplementing the tagging system with an instrumented beam dump.Comment: 19 pages, 7 figures; minor changes, version to appear in EPJ

The OPERA experiment Target Tracker

The main task of the Target Tracker detector of the long baseline neutrino oscillation OPERA experiment is to locate in which of the target elementary constituents, the lead/emulsion bricks, the neutrino interactions have occurred and also to give calorimetric information about each event. The technology used consists in walls of two planes of plastic scintillator strips, one per transverse direction. Wavelength shifting fibres collect the light signal emitted by the scintillator strips and guide it to both ends where it is read by multi-anode photomultiplier tubes. All the elements used in the construction of this detector and its main characteristics are described.Comment: 25 pages, submitted to Nuclear Instrument and Method

Damping of supernova neutrino transitions in stochastic shock-wave density profiles

Supernova neutrino flavor transitions during the shock wave propagation are known to encode relevant information not only about the matter density profile but also about unknown neutrino properties, such as the mass hierarchy (normal or inverted) and the mixing angle theta_13. While previous studies have focussed on "deterministic" density profiles, we investigate the effect of possible stochastic matter density fluctuations in the wake of supernova shock waves. In particular, we study the impact of small-scale fluctuations on the electron (anti)neutrino survival probability, and on the observable spectra of inverse-beta-decay events in future water-Cherenkov detectors. We find that such fluctuations, even with relatively small amplitudes, can have significant damping effects on the flavor transition pattern, and can partly erase the shock-wave imprint on the observable time spectra, especially for sin^2(theta_13) > O(10^-3).Comment: v2 (23 pages, including 6 eps figures). Typos removed, references updated, matches the published versio