Gamma-hydroxybutyrate Reduces GABAA-mediated Inhibitory Postsynaptic Potentials in the CA1 Region of Hippocampus

n/

V-Belt Winding along Archimedean Spirals During the Variator Speed Ratio Shift

Starting from a previous model for the shift mechanics of rubber belt variators, this lecture elaborates practical design formulas for the torque and the axial thrust making use of the very close resemblance of the belt path to a linear spiral of Archimedes along a large part of the arc of contact. In addition, as an alternative to the modern calculus tools, it is shown how the drive variables can be equally calculated applying some propositions of Archimedes' classical treatise περι ‘ελικων (On Spirals)

Hospital environment as a reservoir for cross transmission. Cleaning and disinfection procedures

Background. Healthcare associated infections (HAIs) represent a serious problem for public health, as they increase the morbidity and mortality rates, present a relevant financial burden, and significantly contribute to the antimicrobial resistance. Methods. The aim of this review was to investigate the literature about HAIs, with particular reference to hospital environments and the role of cleaning and disinfection procedures. Hospital environments are an essential reservoir for HAIs cross transmission, and the application of appropriate procedures related to hand hygiene and disinfection/sterilization of surfaces and instruments remain key strategies for controlling HAIs. Results. Different procedures, based on the risk associated with the healthcare procedure, are recommended for hand hygiene: washing with soap and water, antiseptic rubbing with alcohol-based disinfectants, antiseptic and surgical hand washing. Environmental surfaces can be treated with different products, and the mostly used are chlorine-based and polyphenolic disinfectant. The reprocessing of instruments is related to their use according to the Spaulding's classification. In addition, scientific evidence demonstrated the great relevance of the "bundles" (small set of practices performed together) in controlling HAIs. Conclusions. Research agenda should include the improvement of well-known effective preventive procedures and the development of new bundles devoted to high-risk procedures and specific microorganisms

A simple tool to forecast the natural frequencies of thin-walled cylinders

This paper presents an approximate method to predict the natural frequencies of thinwalled cylinders. By taking inspiration from a previous work of one of the authors, the starting point of the proposed approach is a proper construction of reasonable eigenfunctions. However, a new simple tool based on the principle of virtual work has been developed to estimate the natural frequencies and the amplitude of vibration without complex numerical resolution. Moreover, the applicability of the model is extended to all the most common constraint conditions. The identification of the natural frequencies of a continuous cylinder is reduced to an eigenvalue problem based on a matrix whose elements depend only on the geometric characteristics of the cylinder, the mechanical properties of the material and known numerical parameters. The latter are precalculated for given boundary conditions, covering clamped or pinned end constraints. Although the proposed formulation can address any constraints combination, only a pinned-pinned cylinder is analyzed here for brevity. The reliability of the model was tested against FEM analysis results. These comparisons showed that the maximum error versus the exact solutions for the lowest natural frequency is around 2% for all the mode shapes of the pinned-pinned case, offering an excellent trade-off between accuracy and ease of use

Design of a Hybrid Electric Power-Split Transmission for Braking Energy Recovery in a Drilling Rig

Despite the promising potential of the hybrid electric power-split layout, its broader market penetration is prevented by the large number of feasible solutions and the constructive complexity, which overcomplicate the design process. Moreover, due to the lack of relevant literature references, the power-split transmissions design is even more difficult if concerning applications outside the automotive and agricultural sectors. In this paper, a general parametric model already available in the literature to design a single-mode power-split transmission with up to two planetary gear sets and six ordinary gear sets was applied to hybridize an oil drilling rig to recover energy braking during the gravity-driven lowering phases. This is the first power-split electric hybridization of a drilling rig. Two solutions differing in engine power size are presented. Thanks to the modularity of the model, the procedure enabled the optimization of the ICE, the electric machines, and the gear sets through decoupled design phases

Special Issue on Frontiers in Hybrid Vehicles Powertrain

Editoria

Evapotranspiration from an Olive Orchard using Remote Sensing-Based Dual Crop Coefficient Approach

A remote sensing-based approach to estimate actual evapotranspiration (ET) was tested in an area covered by olive trees and characterized by Mediterranean climate. The methodology is a modified version of the standard FAO-56 dual crop coefficient procedure, in which the crop potential transpiration, Tp, is obtained by directly applying the Penman-Monteith (PM) equation with actual canopy characteristics (i.e., leaf area index, albedo and canopy height) derived from optical remote sensing data. Due to the minimum requirement of in-situ ancillary inputs, the methodology is suitable also for applications on large areas where the use of tabled crop coefficient values become problematic, due to the need of corrections for specific crop parameters, i.e., percentage of ground cover, crop height, phenological cycles, etc. The methodology was applied using seven airborne remote sensing images acquired during spring-autumn 2008. The estimates based on PM approach always outperforms the ones obtained using simple crop coefficient constant values. Additionally, the comparison of simulated daily evapotranspiration and transpiration with the values observed by eddy correlation and sap flow techniques, respectively, shows a substantial agreement during both dry and wet days with an accuracy in the order of 0.5 and 0.3 mm d−1, respectively. The obtained results suggest the capability of the proposed approach to correctly partition evaporation and transpiration components during both the irrigation season and rainy period also under conditions of significant reduction of actual ET from the potential one

A cross-sectional study on prevalence and predictors of burnout among a sample of pharmacists employed in pharmacies in Central Italy

Burnout is defined as an occupational phenomenon linked to chronic workplace stress that has not been successfully managed and included among the factors influencing health status or contact with health services. Although several studies were performed for assessing this phenomenon, there is a lack of data on the prevalence of burnout and associated predictors, due to different definitions of the syndrome and heterogeneity of assessment methods. One of the well-known evidences on burnout is related to the highest risk professions, which include policemen, firemen, teachers, psychologists, medical students, nurses, physicians, and other health professionals, such as pharmacists. Objective. The aims of the present study were to (1) assess the occurrence of burnout syndrome among a sample of pharmacists employed in public and private pharmacies located in Rome province (Latium Region; central Italy); (2) evaluate the role of some potential predictors for the development of the syndrome. Materials and Methods. A questionnaire elaborated ad hoc was administered online to 2,000 members of the Association of Professional Pharmacists of Rome and its province and employed in public or private pharmacies. The questionnaire included the 14-item Shirom-Melamed Burnout Measure (SMBM) tool and questions on demographic characteristics and working conditions. Results. Physical exhaustion was the burnout dimension with the highest score; besides, approximately 11% of the studied pharmacists were categorized as having clinically relevant burnout levels (≥4.40). Several of the investigated variables significantly influenced the single burnout dimensions at the univariate analyses; multivariate analyses demonstrated that alcohol consumption and workplace location have a significant independent role on the overall SMBM index, while working time significantly influences clinically relevant burnout level. Conclusions. The results revealed that pharmacists are at risk of burnout, and thus, it is necessary to perform specific preventive intervention for managing this occupational threat

Further insights on predictors of environmental tobacco smoke exposure during the pediatric age

Background: The smoking ban in public places has reduced Environmental Tobacco Smoke (ETS) exposure for non-smokers, but despite this, domestic environments still remain places at high risk of exposure, and, today, about 40% of children worldwide are exposed to ETS at home. The aims of the study are to investigate the contribution of several factors on ETS exposure among a group of Italian children and to evaluate the changes in smoking precautions adopted at home when the smoker is the mother, the father, or both parents, respectively. Methods: A cross-sectional study was performed on a sample of 519 Italian schoolchildren. Information was collected via a questionnaire. Results: 41.4% of the participants lived with at least one smoker. Almost half of the children exposed to ETS lived with one or more smokers who do not observe any home smoking ban. Lower maternal or paternal educational levels significantly increase the risk of ETS exposure at home and the “worst case” is represented by both parents who smoke. Conclusions: More effective preventive interventions are needed to protect children from ETS exposure. Some interventions should be specifically dedicated to smokers with a low educational level and to mothers that smoke

Model predictive control for multimode power-split hybrid electric vehicles: Parametric internal model with integrated mode switch and variable meshing losses

Model predictive control (MPC) is one of the most promising energy management strategies for hybrid electric vehicles. However, owing to constructive complexity, the multimode power-split powertrain requires dedicated mathematical tools to model the mode switch and transmission power losses within the internal model of the controller. Thus, the transmission losses are usually neglected and the mode switch is optimised through offline simulations. This paper proposes an MPC internal model relying on a parametric approach available in the literature, which provides a unique formulation for modelling any power-split transmission and assesses the transmission meshing losses. The objectives, which cover a gap in the literature, are: 1) to integrate the discrete problem of the mode switch in a continuous formulation of the internal model; 2) to compare MPC internal models with different complexity, and evaluate how the consideration of meshing losses and efficiency of the electric machines affect the controller performance. The results on a case study vehicle, i.e., the Chevrolet Volt, suggest that a simplified internal model deteriorates the fuel consumption performance by less than 2 %, while the integrated mode switch is comparable to the offline strategy