Effect of levamisole on immunity to Corynebacterium pseudotuberculosis in mice and sheep

The stimulating effect of levamisole on immunity to Corynebacterium pseudotuberculosis in mice was marginal, while no enhancement of immunity could be detected in sheep. The conclusion was reached that, as levamisole has no potentiating effect on immunity to C. pseudotuberculosis in normal sheep, it is of no practical value as an immunostimulant in this instance.The articles have been scanned in colour with a HP Scanjet 5590; 300dpi. Adobe Acrobat XI Pro was used to OCR the text and also for the merging and conversion to the final presentation PDF-format

Comparative efficacy of six Brucella vaccines in guinea-pigs

Immunity assays in guinea-pigs based on spleen mass: body mass ratios showed that live vaccines were markedly more effective than inactivated oil adjuvant vaccines in providing protection against challenge with 5 000 virulent organisms.This article has been scanned in colour with a HP Scanjet 5590; 300dpi. Adobe Acrobat XI Pro was used to OCR the text and also for the merging and conversion to the final presentation PDF-Format

Evaluation of serological tests as criteria for immunity to staphylococcal skin infection in rabbits

Rabbits immunized with killed whole culture vaccine, bacteria alone or bacteria plus toxoid, were markedly more resistant to skin infection than control rabbits. However, the degree of immunity was not related to the antitoxin or haemagglutinating titres, nor to the opsonizing activity of their sera.The journals have been scanned in colour with a HP 5590 scanner; 600 dpi. Adobe Acrobat v.11 was used to OCR the text and also for the merging and conversion to the final presentation PDF-format

Effective immunization of lambs against enterotoxaemia

In contrast to adult sheep, 2- to 3-month-old lambs do not respond well to a single injection of Clostridium perfringens Type D oil adjuvant epsilon toxoid. This unresponsiveness can be overcome, however, by administering 2 injections of oil adjuvant vaccine or one injection of oil adjuvant followed 4 weeks later by an injection of alum-precipitated toxoid. The latter procedure evokes protective antitoxin levels which persist for 8 months, and a booster injection of alum-precipitated toxoid given at this stage results in an immunity which lasts for at least 1 year.The articles have been scanned in colour with a HP Scanjet 5590; 300dpi. Adobe Acrobat XI Pro was used to OCR the text and also for the merging and conversion to the final presentation PDF-format

Antibody response of guinea-pigs and cattle to a Campylobacter fetus oil emulsion vaccine

A method is described for the mass production of Campylobacter fetus oil emulsion vaccine, using 2 strains of C. fetus ss intestinalis and a strain of C. fetus ss intermedius as a substitute for C. fetus ss venerialis. Heifers, given 2 injections of the vaccine, developed serum antibody titres comparable with the response induced by a commercial product.The articles have been scanned in colour with a HP Scanjet 5590; 600dpi. Adobe Acrobat XI Pro was used to OCR the text and also for the merging and conversion to the final presentation PDF-format

Antiphagocytic activity of Staphylococcus aureus antigens

Systematic fractionation of a capsulated strain of Staphylococcus aureus has led to the isolation of two antigens which would specifically absorb opsonizing antibody from immune rabbit serum. One of these antigens was shown to be serologically identical to teichoic acid. Teichoic acid is considered to be an important antigen for mediating phagocytosis and killing of staphylococci, but other antigens may also play a role in immunity depending on the strain involved, the route of infection, and possible deleterious effects of hypersensitivity reactions.The articles have been scanned in colour with a HP Scanjet 5590; 300dpi. Adobe Acrobat XI Pro was used to OCR the text and also for the merging and conversion to the final presentation PDF-format

The immunizing properties of a Staphylococcus aureus variant possessing surface antigen

A Staphylococcus aureus variant was produced from a typical pathogenic strain by passage in semi-synthetic broth. It possesses surface antigen serologically identical to Smith surface antigen, but the variant differs from typical Smith strains in that it is bound coagulase positive, forms compact colonies in soft serum agar and is avirulent for mice. The surface antigen is immunogenic, but immunity experiments stressed the importance of the protective properties of somatic antigens.The journals have been scanned in colour with a HP 5590 scanner; 600 dpi. Adobe Acrobat v.11 was used to OCR the text and also for the merging and conversion to the final presentation PDF-format

The significance of the endotoxin and pyogenic factor of Corynebacterium pseudotuberculosis in immunity

Two fluid media and methods for the cultivation of C. pseudotuberculosis are described. An average yield of 1·3747 and 0·8566 gm of dry cells per litre was obtained in the respective media. An erythrogenic endotoxin and a pyogenic factor, occurring only in cells grown on blood tryptose agar, have been demonstrated. The endotoxin is inactivated by formalin, but not by phenol, while the reverse is true for the pyogenic factor. Immunity tests in guinea-pigs have shown that cells containing these antigens have appreciably greater immunizing power than those without. This immunogenicity is reduced to a marked degree when the cells are killed by beta-propiolactone, but not by formalin or phenol.The articles have been scanned in colour with a HP scanjet 5590; 300dpi. Adobe Acrobat XI Pro was used to OCR the text and also for the merging and conversion to final presentation PDF-Format

Immunization of mice against Corynebacterium pseudotuberculosis infection

Mice were immunized with vaccines containing whole dry bacteria and adjuvant. They were challenged by the intravenous injection of living bacteria. The degree of immunity obtained was best expressed in terms of the difference in the Tangens values of the cumulative death rates between the immunized and control animals.The articles have been scanned in colour with a HP Scanjet 5590; 300dpi. Adobe Acrobat XI Pro was used to OCR the text and also for the merging and conversion to the final presentation PDF-format

Failure to induce in rabbits effective immunity to a mixed infection of Fusobacterium necrophorum and Corynebacterium pyogenes with a combined bacterin

Rabbits were immunized with alum-precipitated, oil adjuvant and an untreated bacterin composed of F. necrophorum and C. pyogenes. Immunized rabbits were challenged intradermally with a mixture of F. necrophorum and C. pyogenes. Initially a low level of initial transient resistance could be demonstrated but a solid immunity could not be established.The articles have been scanned in colour with a HP Scanjet 5590; 300dpi. Adobe Acrobat XI Pro was used to OCR the text and also for the merging and conversion to the final presentation PDF-format