On the driver of relativistic effects strength in Seyfert galaxies

Spectroscopy of X-ray emission lines emitted in accretion discs around supermassive black holes is one of the most powerful probes of the accretion flow physics and geometry, while also providing in principle observational constraints on the black hole spin.[...] We aim at determining the ultimate physical driver of the strength of this relativistic reprocessing feature. We first extend the hard X-ray flux-limited sample of Seyfert galaxies studied so far (FERO, de la Calle Perez et al. 2010) to obscured objects up to a column density N_H=6x10^23 atoms/cm/cm. We verify that none of the line properties depends on the AGN optical classification, as expected from the Seyfert unification scenarios. There is also no correlation between the accretion disc inclination, as derived from formal fits of the line profiles, and the optical type or host galaxy aspect angle, suggesting that the innermost regions of the accretion disc and the host galaxy plane are not aligned. [...]. Data are not sensitive enough to the detailed ionisation state of the line-emitting disc. However, the lack of dependency of the line EW on either the luminosity or the rest-frame centroid energy rules out that disc ionisation plays an important role on the EW dynamical range in Seyferts. The dynamical range of the relativistically broadened K-alpha iron line EW in nearby Seyferts appears to be mainly determined by the properties of the innermost accretion flow. We discuss several mechanisms (disc ionisation, disc truncation, aberration due to a mildly relativistic outflowing corona) which can explain this. [...] Observational data are still not in contradiction with scenarios invoking different mechanisms for the spectral complexity around the iron line, most notably the "partial covering" absorption scenario. (abridged).Comment: Accepted for publication on Astronomy & Astrophysics. 14 pages, 9 figure

Elevated Serum Sorbitol and not Fructose in Type 2 Diabetic Patients

Reductions in fasting serum fructose or erythrocyte sorbitol have been proposed as markers for early proof of mechanism in clinical development of aldose reductase (AR) inhibitors. However fructose is significantly impacted by meals and evaluation of erythrocyte sorbitol poses technical challenges. To more accurately assess the performance of these markers in biological samples, a gas chromatography-mass spectrometry assay was modified and validated. Serum was collected on three consecutive days from 13 healthy volunteers (HV) and 14 patients with type 2 diabetes mellitus (T2DM), and assayed for sorbitol and fructose using this assay. Serum fructose and sorbitol were relatively constant across the three days. Fasting fructose levels were comparable between the two groups (T2DM: 1.48 ± 0.49 mg/L; HV: 1.39 ± 0.38 mg/L, mean ± standard deviation, P = 0.61), but fasting sorbitol levels were significantly higher in diabetics (T2DM: 0.280 ± 0.163 mg/L; HV: 0.164 ± 0.044 mg/L, P = 0.02). Feeding resulted in a 5–6 fold increase in serum fructose levels, but only a 5%–10% increase in sorbitol. Only sorbitol remained significantly elevated pre- and post feeding in T2DM patients relative to HV. These data suggest that serum sorbitol may be a robust proof of mechanism biomarker and facilitate dose selection for clinical development of AR inhibitors

Nucleon-Nucleon interaction, charge symmetry breaking and renormalization

We study the interplay between charge symmetry breaking and renormalization in the NN system for s-waves. We find a set of universality relations which disentangle explicitly the known long distance dynamics from low energy parameters and extend them to the Coulomb case. We analyze within such an approach the One-Boson-Exchange potential and the theoretical conditions which allow to relate the proton-neutron, proton-proton and neutron-neutron scattering observables without the introduction of extra new parameters and providing good phenomenological success.Comment: 15 pages, 6 figure