Hemostasis biomarkers and incident cognitive impairment: the REGARDS study

Essentials Cognitive disorders are increasing and vascular risk factors play a role in this. We performed a nested case control study of hemostasis biomarkers and cognitive impairment (CI). Higher baseline fibrinogen, factor VIII and D-dimer were related to incident CI over 3.5 years. Adjusted for other risk factors, 2+ abnormal markers (but not single ones) led to higher risk. SUMMARY: Background Vascular risk factors are associated with cognitive impairment, a condition that imposes a substantial public health burden. We hypothesized that hemostasis biomarkers related to vascular disease would be associated with the risk of incident cognitive impairment. Methods We performed a nested case-control study including 1082 participants with 3.5 years of follow-up in the Reasons for Geographic and Racial Differences in Stroke (REGARDS) study, a longitudinal cohort study of 30 239 black and white Americans aged ≥ 45 years. Participants were free of stroke or cognitive impairment at baseline. Baseline D-dimer, fibrinogen, factor VIII and protein C levels were measured in 495 cases who developed cognitive impairment during follow-up (based on abnormal scores on two or more of three cognitive tests) and 587 controls. Results Unadjusted odds ratios (ORs) for incident cognitive impairment were 1.32 (95% confidence interval [CI] 1.02-1.70) for D-dimer > 0.50 μg mL-1 , 1.83 (95% CI 1.24-2.71) for fibrinogen > 90th percentile, 1.63 (95% CI 1.11-2.38) for FVIII > 90th percentile, and 1.10 (95% CI 0.73-1.65) for protein C < 10th percentile. There were no differences in associations by race or region. Adjustment for demographic, vascular and health behavior risk factors attenuated these associations. However, having at least two elevated biomarkers was associated with incident cognitive impairment, with an adjusted OR of 1.73 (95% CI 1.10-2.69). Conclusion Elevated D-dimer, fibrinogen and FVIII levels were not associated with the occurrence of cognitive impairment after multivariable adjustment; however, having at least two abnormal biomarkers was associated with the occurrence of cognitive impairment, suggesting that the burden of these biomarkers is relevant

Correspondences, an exhibition of installations : Peter Burgess et al

Correspondences, an exhibition of installations : Peter Burgess et al Catalogue of Exhibition held at the Tasmanian School of Art, University of Tasmania 4 July-20 July, 1984 Works by Peter Burgess, Peter Callas, Adrian Hall, Maryrose Sinn, Gregory Smith, Neil Stevenson, Alain Viguier, John Youn

Association of Urine Findings with Metabolic Syndrome Traits in a Population of Patients with Nephrolithiasis

Background The odds of nephrolithiasis increase with more metabolic syndrome (MetS) traits. We evaluated associations of metabolic and dietary factors from urine studies and stone composition with MetS traits in a large cohort of stone-forming patients. Methods Patients .18 years old who were evaluated for stones with 24-hour urine collections between July 2009 and December 2018 had their records reviewed retrospectively. Patient factors, laboratory values, and diagnoses were identified within 6 months of urine collection and stone composition within 1 year. Four groups with none, one, two, and three or four MetS traits (hypertension, obesity, dyslipidemia, and diabetes) were evaluated. Trends across groups were tested using linear contrasts in analysis of variance and analysis of covariance. Results A total of 1473 patients met the inclusion criteria (835 with stone composition). MetS groups were 684 with no traits, 425 with one trait, 211 with two traits, and 153 with three or four traits. There were no differences among groups for urine volume, calcium, or ammonium excretion. There was a significant trend (P,0.001) for more MetS traits being associated with decreasing urine pH, increasing age, calculated dietary protein, urine uric acid (UA), oxalate, citrate, titratable acid phosphate, net acid excretion, and UA supersaturation. The ratio of ammonium to net acid excretion did not differ among the groups. After adjustment for protein intake, the fall in urine pH remained strong, while the upward trend in acid excretion was lost. Calcium oxalate stones were most common, but there was a trend for more UA (P,0.001) and fewer calcium phosphate (P50.09) and calcium oxalate stones (P50.01) with more MetS traits. Conclusions Stone-forming patients with MetS have a defined pattern of metabolic and dietary risk factors that contribute to an increased risk of stone formation, including higher acid excretion, largely the result of greater protein intake, and lower urine pH

Bugs in our Pockets: The Risks of Client-Side Scanning

Our increasing reliance on digital technology for personal, economic, and government affairs has made it essential to secure the communications and devices of private citizens, businesses, and governments. This has led to pervasive use of cryptography across society. Despite its evident advantages, law enforcement and national security agencies have argued that the spread of cryptography has hindered access to evidence and intelligence. Some in industry and government now advocate a new technology to access targeted data: client-side scanning (CSS). Instead of weakening encryption or providing law enforcement with backdoor keys to decrypt communications, CSS would enable on-device analysis of data in the clear. If targeted information were detected, its existence and, potentially, its source, would be revealed to the agencies; otherwise, little or no information would leave the client device. Its proponents claim that CSS is a solution to the encryption versus public safety debate: it offers privacy -- in the sense of unimpeded end-to-end encryption -- and the ability to successfully investigate serious crime. In this report, we argue that CSS neither guarantees efficacious crime prevention nor prevents surveillance. Indeed, the effect is the opposite. CSS by its nature creates serious security and privacy risks for all society while the assistance it can provide for law enforcement is at best problematic. There are multiple ways in which client-side scanning can fail, can be evaded, and can be abused.Comment: 46 pages, 3 figure

Two-dimensional gravitation and Sine-Gordon-Solitons

Some aspects of two-dimensional gravity coupled to matter fields, especially to the Sine-Gordon-model are examined. General properties and boundary conditions of possible soliton-solutions are considered. Analytic soliton-solutions are discovered and the structure of the induced space-time geometry is discussed. These solutions have interesting features and may serve as a starting point for further investigations.Comment: 23 pages, latex, references added, to appear in Phys.Rev.

Search for Neutrino Oscillations at the Brookhaven AGS

We report on a search for neutrino oscillations of the type nu/sub ..mu../ ..-->.. nu/sub e/ in a detector located an effective distance of 96m from the neutrino source in the wide band neutrino beam at the Brookhaven AGS. No excess of electron events was observed. The resulting upper limit on the strength of the mixing between nu/sub ..mu../ and nu/sub e/ in the case of large mass difference ..delta..m/sup 2/ = absolute value m/sub 1//sup 2/ - m/sub 2//sup 2/ between the neutrino mass eigenstates m/sub 1/ and m/sub 2/ is sin/sup 2/2..cap alpha.. less than or equal to 3.4 x 10/sup -3/ at 90% CL. The corresponding upper limit for small mass difference is ..delta..m/sup 2/sin2..cap alpha.. < 0.43 eV/sup 2/. 9 refs