Sobre el Ordenamiento de Zamora, 1274

The so-called Ordenamiento de Zamora of 1274 has received scant critical attention, but it prompts several questions: (1) is the extant text an official Ordenamiento of the royal court; (2) was the date affixed by the royal chancery; (3) was it enacted in the Cortes at Zamora; (4) what is the substance of the text? The Ordenamiento is incomplete as it lacks the proper introduction characteristic of authentic royal documents and the customary chancery dating formula. Apart from the inscription, no other document speaks of the Cortes of Zamora and the text makes no reference to the Cortes or to the presence of representatives of municipalities ordinarily summoned to the Cortes. In order to facilitate the prompt resolution of lawsuits, the Ordenamiento focused on four topics: 1. Advocates; 2. Judges; 3. Scribes; and 4. The King. It also listed the casos de corte that belonged exclusively to royal jurisdiction.El llamado Ordenamiento de Zamora de 1274 ha recibido escasa atención crítica, pero plantea varias preguntas: (1) ¿es el texto existente un ordenamiento oficial de la corte real? (2) ¿fue la fecha fijada por la cancillería real? (3) ¿fue decretado en las Cortes de Zamora? (4) ¿cuál es la sustancia del texto? El Ordenamiento es incompleto ya que carece de la introducción característica de los auténticos documentos reales y de la fórmula acostumbrada empleada por la cancillería para fechar tales documentos. Aparte de la inscripción, ningún otro documento habla de las Cortes de Zamora y el texto no hace referencia a las Cortes ni a la presencia de representantes de los concejos ordinariamente convocados a las Cortes. Con el fin de facilitar la pronta resolución de los pleitos, el Ordenamiento se centró en cuatro temas: 1. Abogados; 2. Alcaldes; 3. Escribanos; y 4. El Rey. También enumeró los casos de corte que pertenecían exclusivamente a la jurisdicción real

Impact of Accounting for Logical and Physical Processes on Market Capitalization Measures

This paper puts forth a framework for classifying organizations according to the relative importance of logical processes associated with their knowledge infrastructures. Drawing on financial and accounting valuation methods, differences in market-to-book value of equity are hypothesized due to under-valuation of logical processes per accounting conventions. This paper has implications for finance and accounting valuation of logical processes and hence knowledge-intensive processes

Global patterns and predictors of avian population density

Agencia de Innovación y Desarrollo de Andalucía, Grant/Award Number: EMERGIA20_00252; H2020 Marie Skłodowska- Curie Actions, Grant/ Award Number: 891052; Ministero dell'Istruzione, dell'Università e della Ricerca, Grant/Award Number: Rita Levi Montalcini programAim: How population density varies across animal species in the context of environ- mental gradients, and associated migratory strategies, remains poorly understood. The recent influx of avian trait data and population density estimates allows these patterns to be described and explored in unprecedented detail. This study aims to identify the main macroecological drivers of population density in birds. Location: Global. Time period: 1970–2021. Major taxa studied: Birds (Aves). Methods: We collated a dataset of 5072 local population density estimates for 1853 species and modelled population density as a function of trait and environmental predictors in a Bayesian framework accounting for phylogenetic and spatial autocor- relation. We explored the influence of body mass, diet, primary lifestyle, mating sys- tem, nesting behaviour, territoriality, and migratory behaviour on population density, accounting for a range of environmental variables, including preferred habitat type, primary productivity, precipitation and temperature. Based on this empirical baseline, we then predicted the mean population density for 9089 species of birds and esti- mated global geographic patterns of bird population density. Results: Population density was lower in species with larger body mass and higher trophic levels, and also declined in territorial species, migratory species, brood para- sites and species inhabiting resource-poor habitat types (e.g., deserts). Conversely, population density increased in cooperative breeders. Environmental drivers were most influential for migratory birds, with precipitation and temperature both associ- ated with higher population density. Overall, bird population densities were higher at lower latitudes. Main conclusions: Our results support previous findings on the role of body mass, diet and environmental gradients, but also reveal novel species-specific drivers of avian densities related to reproduction, migration and resource- holding behaviour. Substantial fine-scale variation remains unexplained. We provide a global dataset of population density predictions for use in macroecological analyses and conservation assessments.Agencia de Innovacion y Desarrollo de Andalucia EMERGIA20_00252H2020 Marie Sklodowska-Curie Actions 891052Ministry of Education, Universities and Research (MIUR

Combination Therapy with Radiation and PARP Inhibition Enhances Responsiveness to Anti-PD-1 Therapy in Colorectal Tumor Models.

PURPOSE: The majority of colorectal cancers are resistant to cancer immune checkpoint inhibitors. Ionizing radiation (IR) and several radiosensitizers, including PARP inhibitors, can enhance responsiveness to immune checkpoint inhibitors by potentially complementary mechanisms of action. We assessed the ability of radiation and PARP inhibition to induce proimmunogenic changes in tumor cells and enhance their in vivo responsiveness to anti-PD-1 antibodies. METHODS AND MATERIALS: We performed a candidate drug screen and used flow cytometry to assess effects of the PARP inhibitor veliparib on IR-mediated changes in MHC-1 antigen presentation and surface localization of immune-modulating proteins including PD-L1 and calreticulin in colorectal cancer tumor models. Reverse transcription polymerase chain reaction was used to assess the effects of veliparib and radiation on the expression of proinflammatory and immunosuppressive cytokines. The ability of concurrent PARP inhibition and subablative doses of radiation therapy to enhance in vivo responsiveness to anti-PD-1 antibodies was assessed using unilateral flank-tumor models with or without T-cell depletion. RESULTS: Veliparib was a potent radiosensitizer in both cell lines. Radiation increased surface localization of MHC-1 and PD-L1 in a dose-dependent manner, and veliparib pretreatment significantly enhanced these effects with high (8 Gy) but not with lower radiation doses. Enhancement of MHC-1 and PD-L1 surface localization by IR and IR+ veliparib remained significant 1, 3, and 7 days after treatment. IR significantly increased delayed tumoral expression of proinflammatory cytokines interferon-Ƴ and CXCL10 but had no significant effect on the expression of IL-6 or TGF-β. Concurrent administration of veliparib and subablative radiation therapy (8 Gy × 2) significantly prolonged anti-PD-1-mediated in vivo tumor growth delay and survival in both tumor models. Moreover, these effects were more pronounced in the microsatellite instability-mutated MC38 tumor model. Enhancement of anti-PD-1 mediated tumor growth delay with veliparib and IR was attenuated by CD8+ T-cell depletion. CONCLUSIONS: We provide preclinical evidence for a novel therapeutic strategy to enhance responsiveness of colorectal tumors to immune checkpoint inhibitors

Random walk with barriers: Diffusion restricted by permeable membranes

Restrictions to molecular motion by barriers (membranes) are ubiquitous in biological tissues, porous media and composite materials. A major challenge is to characterize the microstructure of a material or an organism nondestructively using a bulk transport measurement. Here we demonstrate how the long-range structural correlations introduced by permeable membranes give rise to distinct features of transport. We consider Brownian motion restricted by randomly placed and oriented permeable membranes and focus on the disorder-averaged diffusion propagator using a scattering approach. The renormalization group solution reveals a scaling behavior of the diffusion coefficient for large times, with a characteristically slow inverse square root time dependence. The predicted time dependence of the diffusion coefficient agrees well with Monte Carlo simulations in two dimensions. Our results can be used to identify permeable membranes as restrictions to transport in disordered materials and in biological tissues, and to quantify their permeability and surface area.Comment: 8 pages, 3 figures; origin of dispersion clarified, refs adde

Final report on project SP1210: Lowland peatland systems in England and Wales – evaluating greenhouse gas fluxes and carbon balances

Lowland peatlands represent one of the most carbon-rich ecosystems in the UK. As a result of widespread habitat modification and drainage to support agriculture and peat extraction, they have been converted from natural carbon sinks into major carbon sources, and are now amongst the largest sources of greenhouse gas (GHG) emissions from the UK land-use sector. Despite this, they have previously received relatively little policy attention, and measures to reduce GHG emissions either through re-wetting and restoration or improved management of agricultural land remain at a relatively early stage. In part, this has stemmed from a lack of reliable measurements on the carbon and GHG balance of UK lowland peatlands. This project aimed to address this evidence gap via an unprecedented programme of consistent, multi year field measurements at a total of 15 lowland peatland sites in England and Wales, ranging from conservation managed ‘near-natural’ ecosystems to intensively managed agricultural and extraction sites. The use of standardised measurement and data analysis protocols allowed the magnitude of GHG emissions and removals by peatlands to be quantified across this heterogeneous data set, and for controlling factors to be identified. The network of seven flux towers established during the project is believed to be unique on peatlands globally, and has provided new insights into the processes the control GHG fluxes in lowland peatlands. The work undertaken is intended to support the future development and implementation of agricultural management and restoration measures aimed at reducing the contribution of these important ecosystems to UK GHG emissions