7 research outputs found
Stress hematopoiesis reveals abnormal control of self-renewal, lineage bias, and myeloid differentiation in Mll partial tandem duplication (Mll-PTD) hematopoietic stem/progenitor cells
10.1182/blood-2012-02-412379Blood12051118-1129BLOO
Prognostic gene mutations and distinct gene- and microRNA-expression signatures in acute myeloid leukemia with a sole trisomy 8
Trisomy 8 (+8) is the most frequent numerical chromosome aberration in acute myeloid leukemia (AML), occurring in ~9% of adult patients.1 In one-third of such patients, +8 is the sole cytogenetic abnormality.1 These patients are mostly classified as having an intermediate prognosis.1, 2 The few available studies suggest that sole +8 AML is molecularly heterogeneous,3, 4, 5 but the clinical impact of mutations remains to be established. Moreover, although the biologic features of sole +8 AML have been investigated using genome-wide gene-6, 7 or microRNA-expression8 analyses, these studies included small numbers of patients
Linseed essential oil - source of lipids as active ingredients for pharmaceuticals and nutraceuticals
Linseed - also known as flaxseed - is known for its beneficial effects on animal
health attributed to its composition. Linseed comprises linoleic and ?-linolenic fatty acids,
various dietary fibers and lignans, which are beneficial to health because they reduce the risk
of cardiovascular diseases, as well as cancer, decreasing the levels of cholesterol and relaxing
the smooth muscle cells in arteries increasing the blood flow. Essential fatty acids from flax
participate in several metabolic processes of the cell, not only as structuring components of
the cell membrane but also as storage lipids. Flax, being considered a functional food, can be
consumed in a variety of ways, including seeds, oil or flour, contributing to basic nutrition.
Several formulations containing flax are available on the market in the form of e.g. capsules
and microencapsulated powders having potential as nutraceuticals. This paper revises the different
lipid classes found in flaxseeds and their genomics. It also discusses the beneficial effects
of flax and flaxseed oil and their biological advantages as ingredients in pharmaceuticals
and in nutraceuticals products.The authors wish to acknowledge the financial support from the Portuguese Science and Technology Foundation, Ministry of Science and Education (FCT/MEC) through national funds, and co-financed by FEDER, under the Partnership Agreement PT2020 for the project M-ERA-NET/0004/2015-PAIRED.info:eu-repo/semantics/publishedVersio