Adaptation and integration of migrants in russia: experience of migration centers and organizations in sverdlovsk oblast

В связи с недавними изменениями российского законодательства, посвященного адаптации и интеграции мигрантов, исполнением новых правил и стандартов занимаются государственные и общественные институты. Однако по сообщениям средств массовой информации при реализации нового закона возникают проблемы. Используя полуструктурированные интервью с сотрудниками центров и организаций, работающих над темой миграции, автор рассматривает опыт таких учреждений в Свердловской области. При помощи информации, полученной в ходе опросов, удалось проанализировать местную ситуацию и сформулировать выводы о роли таких институтов в процессах адаптации и интеграции мигрантов.In connection with recent changes in Russian law on the adaptation and integration of migrants, governmental and civil society institutions have been engaging in the execution of these new rules and standards. However, according to media sources, problems have arose in the implementation of the new law. Using semi-structured interviews with staff of centers and organizations working on the topic of migration, the author considers the experience of such establishments in the Sverdlovsk region. With the help of information collected from the interviews, the local situation is analyzed, and conclusions are formulated on the role of such institutions in the adaptation and integration of migrants

Role of problem interpretations in understanding the development of everyday problem solving

Journal ArticleImagine the following conversation between an 11-year-old and a 14-year-old. The two are fighting over how best to solve a problem that the 14-year-old experienced while working on a project at school. The problem involved completing the project so that it would be competitive for the class prize. The project partner no longer wishes to work with the 14-year-old as the partner thought the student was too bossy. The 11-year-old indicates that buckling down and doing the things that are needed to finish the project and win the prize is the best course of action. The 14-year-old, however, states that the best way to solve the problem is to talk with the project partner and convince the partner that you will be less bossy

There is a short gamma-ray burst prompt phase at the beginning of each long one

We compare the prompt intrinsic spectral properties of a sample of short Gamma--ray Burst (GRB) with the first 0.3 seconds (rest frame) of long GRBs observed by Fermi/GBM. We find that short GRBs and the first part of long GRBs lie on the same E_p--E_iso correlation, that is parallel to the relation for the time averaged spectra of long GRBs. Moreover, they are indistinguishable in the E_p--L_iso plane. This suggests that the emission mechanism is the same for short and for the beginning of long events, and both short and long GRBs are very similar phenomena, occurring on different timescales. If the central engine of a long GRB would stop after ~0.3 * (1+z) seconds the resulting event would be spectrally indistinguishable from a short GRB.Comment: 14 pages, 6 figures, MNRAS accepte

Dissolved CO2 in natural waters: development of an automated monitoring system and first application to Stromboli volcano (Italy)

The study of geochemical parameters applied to natural systems has provided improved knowledge of geochemical mechanisms of gas/rock dissolution in natural waters that are linked to gas–water and/or water– rock interaction processes. Here we present the results of our studies focused on the development of an automated monitoring system for measuring the amount of dissolved CO2 in natural waters. The system is based on the principle of a dynamic equilibrium between water and the air as the host gas. The PCO2 measurements were carried out every four hours, and the equilibration time was around 20 minutes. Moreover, application to the thermal aquifer of Stromboli volcano during the 2009-2010 period is shown and analyzed. The data highlight a clear correlation between the changes in the PCO2 in the thermal aquifer and the changes in volcanic activity

IBA57 recruits ISCA2 to form a [2Fe-2S] cluster-mediated complex

The maturation of mitochondrial iron-sulfur proteins requires a complex protein machinery. Human IBA57 protein was proposed to act in a late phase of this machinery, along with GLRX5, ISCA1, and ISCA2. However, a molecular picture on how these proteins cooperate is not defined yet. We show here that IBA57 forms a heterodimeric complex with ISCA2 by bridging a [2Fe-2S] cluster, that [2Fe-2S] cluster binding is absolutely required to promote the complex formation, and that the cysteine of the conserved motif characterizing IBA57 protein family and the three conserved cysteines of the ISCA protein family act as cluster ligands. The [2Fe-2S] heterodimeric complex is the final product when IBA57 is either exposed to [2Fe-2S] ISCA2 or in the presence of [2Fe-2S] GLRX5 and apo ISCA2. We also find that the [2Fe-2S] ISCA2-IBA57 complex is resistant to highly oxidative environments and is capable of reactivating apo aconitase in vitro. Collectively, our data delinate a [2Fe-2S] cluster transfer pathway involving three partner proteins of the mitochondrial ISC machinery, that is, GLRX5, ISCA2 and IBA57, which leads to the formation of a [2Fe-2S] ISCA2-IBA57 complex

A structure-based proposal for the catalytic mechanism of the bacterial acid phosphatase AphA belonging to the DDDD superfamily of phosphohydrolases

The Escherichia coli gene aphA codes for a periplasmic acid phosphatase called AphA, belonging to class B bacterial phosphatases, which is part of the DDDD superfamily of phosphohydrolases. After our first report about its crystal structure, we have started a series of crystallographic studies aimed at understanding of the catalytic mechanism of the enzyme. Here, we report three crystal structures of the AphA enzyme in complex with the hydrolysis products of nucleoside monophosphate substrates and a fourth with a proposed intermediate analogue that appears to be covalently bound to the enzyme. Comparison with the native enzyme structure and with the available X-ray structures of different phosphatases provides clues about the enzyme chemistry and allows us to propose a catalytic mechanism for AphA, and to discuss it with respect to the mechanism of other bacterial and human phosphatases. (c) 2005 Elsevier Ltd. All rights reserved

SARS-CoV-2 Mproinhibition by a zinc ion: structural features and hints for drug design

The first structure of the SARS-CoV-2 main protease in complex with an isolated zinc ion provides solid ground for the design of potent and selective metal-conjugated inhibitors

Strain and Magnetic Fabric in Santa Catalina and Pinaleno Mountains Metamorphic- Core-Complexes Mylonite Zones, Arizona

Anisotropy of magnetic susceptibility (AMS) is capable of recording finite strain in weakly magnetized rocks. AMS was measured for 228 samples from 20 sites in two mylonite zones with the same deformational history. AMS measurements were compared with finite strains determined from dike rotations and from foliation orientations. In one zone (the Santa Catalina Mountains) the orientations of susceptibility and finite strain ellipsoids are in excellent agreement, and there is a logarithmic relationship between susceptibility difference (ΔKi = [Ki-K]/K) and finite strain magnitude. In the second zone (the Pinaleno Mountains) minimum susceptibility is perpendicular to the finite flattening plane, but the maximum susceptibility does not parallel the maximum extension direction, and there is no systematic relationship between susceptibility magnitude and strain magnitude. Oriented polished thin sections indicate that magnetite in the protolith of the Santa Catalina mylonite occurs as randomly oriented, elongate grains. With subsequent deformation, the long axes are rotated into the maximum extension direction. In the Pinaleno mylonites, both equant and elongate magnetite grains are present. With deformation, the elongate magnetite grains are rotated into the maximum flattening plane but show no preferred orientation within this plane. AMS in the two mylonite zones appears to be predominantly controlled by the orientation of elongate magnetite grains with respect to the megascopic fabric. The final orientation of the elongate grains is a function of their initial orientation as well as the finite strain. Therefore, despite similar deformational histories, the two zones display different AMS patterns due to the differences in occurrence, initial orientation, and shape of ferromagnetic grains

Memantine prodrug as a new agent for alzheimer’s disease

Hydrogen sulphide has recently drawn much attention due to its potent anti-inflammatory and neuroprotective roles in brain functions. The purpose of the current study was to exploit these beneficial properties of H 2 S to design a new agent for the treatment of Alzheimer’s disease (AD). To pursue our aims, we replaced the free amine group of memantine with an isothiocyanate functionality as a putative H 2 S-donor moiety. The new chemical entity, named memit, was then tested in vitro to determine whether it retains the pharmacological profile of the “native drug”, while also providing a source of H 2 S in the CNS. Indeed, Memit showed the ability to release H 2 S through a cysteine-mediated mechanism, thus generating memantine. Moreover, the new hybrid molecule exerts protective effects against neuronal inflammation and induces a drastic fall in ROS production. In addition, memit was also able to reduce the Aβ(1-42) self-induced aggregation and exerted cytoprotective effect against Aβ oligomers-induced damage in both human neurons and rat microglia cells. Finally, similarly to memantine, the new compound promotes autophagy, a complex process required for cellular homeostasis in cell survival that results to be altered in neurodegenerative diseases. In conclusion, our study revealed that memit is a prodrug of memantine. Further in vivo studies will be necessary to fully investigate the synergic or cumulative effects due to the H 2 S-releasing moiety and the native drug

Continuous SO2 flux measurements for Vulcano Island, Italy

The La Fossa cone of Vulcano Island (Aeolian Archipelago, Italy) is a closed conduit volcano. Today, Vulcano Island is characterized by sulfataric activity, with a large fumarolic field that is mainly located in the summit area. A scanning differential optical absorption spectroscopy instrument designed by the Optical Sensing Group of Chalmers University of Technology in Göteborg, Sweden, was installed in the framework of the European project "Network for Observation of Volcanic and Atmospheric Change", in March 2008. This study presents the first dataset of SO2 plume fluxes recorded for a closed volcanic system. Between 2008 and 2010, the SO2 fluxes recorded showed average values of 12 t.d—1 during the normal sulfataric activity of Vulcano Island, with one exceptional event of strong degassing that occurred between September and December, 2009, when the SO2 emissions reached up to 100 t.d—1