Lesão Erosiva do Mamilo

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Metástases Tardias de Melanoma Maligno Cutâneo Primário Fino

Cutaneous malignant melanoma is the third most common type of skin cancer, and its incidence has been rising. Its mortality rate is considerable, due to an aggressive phenotype and great ability of dissemination, mainly in the first years of follow- -up. Late recurrences, those presenting more than 10 years after diagnosis, are rare. The main prognostic factor of cutaneous malignant melanoma is tumor thickness, which also guides management. Thin tumors often have a good prognosis. We report a case of a 66-year-old woman with a history of excision of a thin primary cutaneous malignant melanoma of the dorsum, presenting 16 years later with an unexpected, rapidly progressing and lethal recurrence.O melanoma maligno cutâneo é o terceiro tipo mais comum de cancro de pele, e a sua incidência tem aumentado. A taxa de mortalidade associada é considerável, devido ao seu fenótipo agressivo e grande capacidade de metastização, principalmente nos primeiros anos de seguimento. As recidivas tardias, mais de 10 anos após o diagnóstico, são raras. O principal fator de prognóstico do melanoma maligno cutâneo é a espessura tumoral, que também determina o tipo de abordagem. Os tumores finos, geralmente, têm bom prognóstico. Reportamos o caso de uma mulher de 66 anos com antecedentes de excisão de um melanoma maligno cutâneo primário fino, localizado no dorso, que se apresentou 16 anos mais tarde com uma inesperada recidiva, rapidamente progressiva e letal

Meyerson Nevus Mimicking Malignant Melanoma

Meyerson nevus represents an uncommon clinical and histological variation of melanocytic lesions that is characterized by an eczematous halo surrounding a melanocytic nevus.1 It was first reported by Meyerson and it typically clears spontaneously or resolves with topical corticotherapy.2 We report the case of an atypical Meyerson nevus in which, despite intense pruritus, both an eczematous eruption and dermoscopic patterns imputable to a melanocytic lesion were lacking. 1. Balato A, Lembo S, Cirillo T, Megna M, Napolitano M, Balat N. Meyerson phenomenon around naevi: resolution after sun exposure? Acta Dermato-Venereol. 2011; 91:352-3. doi: 10.2340/00015555-1059. 2. Gabbi TV, Omar ED, Criado PR, Valente NY, Martins JE. Clinical, dermoscopic and histopathological evaluation of the Meyerson nevus: case report. An Bras Dermatol. 2010;85:681-3

Anatomical study of the sphenopalatine foramen

As variações anatômicas do forame esfenopalatino podem corresponder às alterações na entrada da irrigação nasal arterial, condição relevante para o tratamento das epistaxes graves através da ligadura da artéria esfenopalatina. OBJETIVO: Estudar o forame esfenopalatino quanto à sua variação numérica e sua localização na parede lateral nasal em relação à crista etmoidal óssea do osso palatino. Material e Método: Os estudos anatômicos foram realizados em 54 hemicrânios. RESULTADOS: O forame esfenopalatino apresentou a seguinte variação numérica: único (87,0% ou 47 peças), duplo (11,1% ou 6 peças) e triplo (1,9% ou uma peça); foi localizado no meato nasal superior em 81,5% ou 44 peças, 14,8% (8 peças) entre os meatos nasais médio e superior e no meato nasal médio apenas em um caso (1,9%). CONCLUSÃO: Foi demonstrada a variação numérica do FEP, a sua relação com a crista etmoidal óssea, e sua localização nos meatos nasais superior, médio e em ambos.Anatomical variations of the sphenopalatine foramen may correspond to alterations at the arterial nasal irrigation input, which is a relevant condition to treat severe epistaxis through ligation of the sphenopalatine artery. AIM: To study the sphenopalatine foramen in terms of its numeric variation and its location on the lateral nasal wall in relation to the bony ethmoidal crest of the palatine bone. MATERIALS AND METHODS: The anatomical studies were carried out in 54 hemifaces. RESULTS: the sphenopalatine foramen presented the following numeric variation: single (87%, or 47 specimens), double (11,1%, or 6 specimens), and triple (1.9% or one specimen); it was located at the superior nasal meatus in 81.5%, or 44 specimens; 14.8% (8 specimens) between the middle and superior nasal meatus and in the middle nasal meatus in only one case (1.9%). CONCLUSION: We have been able to show a numeric variation of the SPF, its relation with the bony ethmoidal crest and its location in the superior meatus, middle meatus, and in both

Tomographic study of Jaw bone changes in patients with bisphosphonate-related osteonecrosis

Bisphosphonates (BP) are synthetic pyrophosphate-like substances with antiresorptive properties and specifically affect osteoclastic activity. In 2007, the American Association of Oral and Maxillofacial Surgeons (AAOMS) defined diagnostic criteria for Osteonecrosis of the Jaws Associated with Bisphosponates (BRONJ). BRONJ is mainly diagnosed by clinical features, but the detection of early bone changes by imaging may help prevent and better understand the disease. The objective of this study was to evaluate maxillary changes in CBCT in patients using BP. All included patients were diagnosed with osteonecrosis and received bisphosphonate drugs in the last ten years. All imaging examinations were obtained by I-CAT and 3D Accuitomo. The multiplanar reconstructions were analyzed by an examiner without knowledge of the clinical aspects and location of the lesions. The study sample consisted of 21 patients, the majority of the sample represented patients with cancer (76.2%), the other patients had osteoporosis (23.8%). Only four patients (19.04%) received alendronate, while intravenous bisphosphonates, such as zoledronate and pamidronate, represented the treatment of most of our sample. Most of our patients presented stage 1 and 2 MRONJ (85.7%), whose lesions were mainly observed in the mandible (52.4%). Fifty-seven percent of the patients had at least one bone change. In BRONJ, bone changes vary between exposed and non-exposed areas and one aspect of the study was: persistent extraction cavities in the BRONJ lesion region and high frequency of periodontal ligament space widening in areas that are not involved in BRONJ lesions. This reflects the very important role of dental and periodontal diseases in the pathophysiology of BRONJ. Thus, preventive measures should be prioritized for patients exposed to anti-resorptive drugs

Spectroscopic characterization of schiff base-copper complexes immobilized in smectite clays

Herein, the immobilization of some Schiff base-copper(II) complexes in smectite clays is described as a strategy for the heterogenization of homogeneous catalysts. The obtained materials were characterized by spectroscopic techniques, mostly UV/Vis, EPR, XANES and luminescence spectroscopy. SWy-2 and synthetic Laponite clays were used for the immobilization of two different complexes that have previously shown catalytic activity in the dismutation of superoxide radicals, and disproportionation of hydrogen peroxide. The obtained results indicated the occurrence of an intriguing intramolecular redox process involving copper and the imine ligand at the surface of the clays. These studies are supported by computational calculations