Creativity and cross-institutional collaboration in the DigiDex Community of Practice

Responding to industry need, the Council of Australian University Librarians (CAUL) sector-wide approach to developing digital dexterity established a unique practitioner-led network and Community of Practice (CoP). This paper focuses on how a core-group (Digital Dexterity Champions) within the cross-institutional CoP has self-formed a flourishing learning culture that fosters creativity. We explore aspects underpinning the creative collaboration evident within the Champions culture. In sharing stories of creative library practice, we highlight the generative power of initiatives that nurture a sharing culture. We argue for the value of supporting cross-boundary spaces that enable individuals to work creatively together

Predicting the birth of a spoken word

Children learn words through an accumulation of interactions grounded in context. Although many factors in the learning environment have been shown to contribute to word learning in individual studies, no empirical synthesis connects across factors. We introduce a new ultradense corpus of audio and video recordings of a single child’s life that allows us to measure the child’s experience of each word in his vocabulary. This corpus provides the first direct comparison, to our knowledge, between different predictors of the child’s production of individual words. We develop a series of new measures of the distinctiveness of the spatial, temporal, and linguistic contexts in which a word appears, and show that these measures are stronger predictors of learning than frequency of use and that, unlike frequency, they play a consistent role across different syntactic categories. Our findings provide a concrete instantiation of classic ideas about the role of coherent activities in word learning and demonstrate the value of multimodal data in understanding children’s language acquisition

Modelling size-fractionated primary production in the Atlantic Ocean from remote sensing

This is the author accepted manuscript. The final version is available from Elsevier via the DOI in this recordMarine primary production influences the transfer of carbon dioxide between the ocean and atmosphere, and the availability of energy for the pelagic food web. Both the rate and the fate of organic carbon from primary production are dependent on phytoplankton size. A key aim of the Atlantic Meridional Transect (AMT) programme has been to quantify biological carbon cycling in the Atlantic Ocean and measurements of total primary production have been routinely made on AMT cruises, as well as additional measurements of size-fractionated primary production on some cruises. Measurements of total primary production collected on the AMT have been used to evaluate remote-sensing techniques capable of producing basin-scale estimates of primary production. Though models exist to estimate size-fractionated primary production from satellite data, these have not been well validated in the Atlantic Ocean, and have been parameterised using measurements of phytoplankton pigments rather than direct measurements of phytoplankton size structure. Here, we re-tune a remote-sensing primary production model to estimate production in three size fractions of phytoplankton (10 μm) in the Atlantic Ocean, using measurements of size-fractionated chlorophyll and size-fractionated photosynthesis-irradiance experiments conducted on AMT 22 and 23 using sequential filtration-based methods. The performance of the remote-sensing technique was evaluated using: (i) independent estimates of size-fractionated primary production collected on a number of AMT cruises using 14C on-deck incubation experiments and (ii) Monte Carlo simulations. Considering uncertainty in the satellite inputs and model parameters, we estimate an average model error of between 0.27 and 0.63 for log10-transformed size-fractionated production, with lower errors for the small size class (10 μm), and errors generally higher in oligotrophic waters. Application to satellite data in 2007 suggests the contribution of cells 2 μm to total primary production is approximately equal in the Atlantic Ocean.UK National Centre for Earth ObservationNatural Environment Research Council (NERC)Plymouth Marine Laborator

Post-exposure intranasal IFNα suppresses replication and neuroinvasion of Venezuelan Equine Encephalitis virus within olfactory sensory neurons

BACKGROUND: Venezuelan Equine Encephalitis virus (VEEV) may enter the central nervous system (CNS) within olfactory sensory neurons (OSN) that originate in the nasal cavity after intranasal exposure. While it is known that VEEV has evolved several mechanisms to inhibit type I interferon (IFN) signaling within infected cells, whether this inhibits virologic control during neuroinvasion along OSN has not been studied. METHODS: We utilized an established murine model of intranasal infection with VEEV and a repository of scRNAseq data from IFN-treated OSN to assess the cellular targets and IFN signaling responses after VEEV exposure. RESULTS: We found that immature OSN, which express higher levels of the VEEV receptor LDLRAD3 than mature OSN, are the first cells infected by VEEV. Despite rapid VEEV neuroinvasion after intranasal exposure, olfactory neuroepithelium (ONE) and olfactory bulb (OB) IFN responses, as assessed by evaluation of expression of interferon signaling genes (ISG), are delayed for up to 48 h during VEEV neuroinvasion, representing a potential therapeutic window. Indeed, a single intranasal dose of recombinant IFNα triggers early ISG expression in both the nasal cavity and OB. When administered at the time of or early after infection, IFNα treatment delayed onset of sequelae associated with encephalitis and extended survival by several days. VEEV replication after IFN treatment was also transiently suppressed in the ONE, which inhibited subsequent invasion into the CNS. CONCLUSIONS: Our results demonstrate a critical and promising first evaluation of intranasal IFNα for the treatment of human encephalitic alphavirus exposures

The Politics of Commerce : The Congress of Chambers of Commerce of the Empire, 1886-1914

Peer reviewedPublisher PD

Archival ethics: The truth of the matter

This essay explores the question of whether records professionals are as aware of the ethical dimensions of their work as they should be. It consider first the historical and professional context of archival ethics, then examines a recent case about business archives involving the author that suggests the need for renewed attention to professional ethics, and concludes with a discussion about how archivists might reconsider the ethical dimensions of their work

A Comparative Study of Cellular Diversity between the Xenopus Pronephric and Mouse Metanephric Nephron

The kidney is an essential organ that ensures bodily fluid homeostasis and removes soluble waste products from the organism. Nephrons, the functional units of the kidney, comprise a blood filter, the glomerulus or glomus, and an epithelial tubule that processes the filtrate from the blood or coelom and selectively reabsorbs solutes, such as sugars, proteins, ions, and water, leaving waste products to be eliminated in the urine. Genes coding for transporters are segmentally expressed, enabling the nephron to sequentially process the filtrate. The Xenopus embryonic kidney, the pronephros, which consists of a single large nephron, has served as a valuable model to identify genes involved in nephron formation and patterning. Therefore, the developmental patterning program that generates these segments is of great interest. Prior work has defined the gene expression profiles of Xenopus nephron segments via in situ hybridization strategies, but a comprehensive understanding of the cellular makeup of the pronephric kidney remains incomplete. Here, we carried out single-cell mRNA sequencing of the functional Xenopus pronephric nephron and evaluated its cellular composition through comparative analyses with previous Xenopus studies and single-cell mRNA sequencing of the adult mouse kidney. This study reconstructs the cellular makeup of the pronephric kidney and identifies conserved cells, segments, and associated gene expression profiles. Thus, our data highlight significant conservation in podocytes, proximal and distal tubule cells, and divergence in cellular composition underlying the capacity of each nephron to remove wastes in the form of urine, while emphasizing the Xenopus pronephros as a model for physiology and disease

Influence diagnostics for the proportional hazards model

Influence diagnostics based on Cook's curvature diagnostic (1986) are developed for the proportional hazards model. Three perturbation schemes are considered: perturbation of the likelihood, perturbation of the censoring information and perturbation of covariate values.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/28377/1/0000142.pd

Altered processing of procholecystokinin in carboxypeptidase E‐deficient fat mice: differential synthesis in neurons and endocrine cells

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/116993/1/feb2s0014579398010990.pd

Assessing school-aged children’s inference making:the effect of test story format in listening comprehension

Background. Comprehension is critical for classroom learning and educational success. Inferences are integral to good comprehension: Successful comprehension requires the listener to generate local coherence inferences, which involve integrating information between clauses, and global coherence inferences, which involve integrating textual information with background knowledge to infer motivations, themes, etc. A central priority for the diagnosis of comprehension difficulties and our understanding of why these difficulties arise is the development of valid assessment instruments.Aims. We explored typically developing children’s ability to make local and global coherence inferences using a novel assessment of listening comprehension. Our aims were to determine whether children were more likely to make the target inferences when these were asked during story presentation vs. after presentation of the story, and whether there were any age differences between conditions.Methods & Procedures. Children in Years 3 (n=29) and 5 (n=31) listened to short stories presented either in a segmented format, in which questions to assess local and global coherence inferences were asked at specific points during story presentation, or in a whole format, when all of the questions were asked after the story had been presented.Outcomes & Results. There was developmental progression between age groups for both types of inference question. Children also scored higher on the global coherence inference questions than the local coherence inference questions. There was a benefit of the segmented format for younger children, particularly for the local inference questions. Conclusions & Implications. The results suggest that children are more likely to make target inferences if prompted during presentation of the story, and that this format is particularly facilitative for younger children and for local coherence inferences. This has implications for the design of comprehension assessments as well as for supporting children with comprehension difficulties in the classroom