10 research outputs found
Prevalence and evolution of Mycobacterium tuberculosis infection in tuberculosis case contacts
PrevalĂȘncia de resistĂȘncia primĂĄria em pacientes com tuberculose pulmonar sem fatores de risco conhecidos para resistĂȘncia primĂĄria
Yield of close contact tracing using two different programmatic approaches from tuberculosis index cases: a retrospective quasi-experimental study
Infecção latente por tuberculose entre pessoas com HIV/AIDS, fatores associados e progressĂŁo para doença ativa em municĂpio no Sul do Brasil
Rate of tuberculosis infection in children and adolescents with household contact with adults with active pulmonary tuberculosis as assessed by tuberculin skin test and interferon-gamma release assays
Tuberculosis incidence among contacts of active pulmonary tuberculosis
BACKGROUND: Treatment of latent tuberculosis (TB) infection (LTBI) in Brazil is recommended only in the case of contacts of pulmonary smear-positive TB patients aged <= 15 years with a tuberculin skin test (TST) >= 10 mm and no previous bacille Calmette-Guerin (BCG) vaccination or with a TST >= 15 mm regardless of previous BCG vaccination. OBJECTIVE: To evaluate the 2-year incidence and predictors of TB among contacts who did not meet the Brazilian criteria for LTBI treatment. DESIGN: Retrospective cohort study. Contacts aged between 12 and 15 years and those aged >15 years who did not meet the Brazilian criteria for LTBI treatment were enrolled in the study. RESULTS: TB incidence was 3.2% (22/667), with an estimated TB rate of 1649 per 100000 population. Risk of TB was greater among the 349 contacts with TST >= 5 mm (5.4%) compared to the 318 contacts with TST <5 mm, (0.9%; RR 6.04, 95%CI 1.7-20.6). CONCLUSION: The high incidence of TB among contacts who did not meet the Brazilian criteria for LTBI treatment strongly suggests that these criteria should be reviewed. Furthermore, even among BCG-vaccinated contacts, TST induration >= 5 mm, was the only variable that predicted the development of TB disease within 2 years.CNPq Conselho Nacional de Desenvolvimento Cientifico e Tecnologico[350543/2003-8