2,293 research outputs found
Confucian Principles: A Study of Chinese Americansā Interpersonal Relationships in Selected Childrenās Picturebooks
[[abstract]]There has not been enough critical analysis of childrenās literature by and about Chinese Americans, especially when compared to other minority groups in the United States. In particular, Chinese American historical books lack extensive analysis. It is important to reflect cultural accuracy in literature and to help children develop clear concepts of self and others by providing precise cultural and physical characteristics of people. While cultural authenticity allows children the opportunity to see a reflection of real experiences within a book instead of seeing stereotypes or misrepresentations, obtaining correct information about a certain time period can help children to see images of immigration accurately represented in literature. Using the Confucian delineation of interpersonal relationships as the major criterion of cultural authenticity, this article examines three currently available childrenās picturebooks set in the historical period between 1848 and 1885. In addition to exploring how Chinese Americansā interpersonal relationships are portrayed in these childrenās historical books, this article argues for more proactive inclusion of the diversity in selection of picturebooks.[[notice]]č£ę£å®
When Anomaly Mediation is UV Sensitive
Despite its successes---such as solving the supersymmetric flavor
problem---anomaly mediated supersymmetry breaking is untenable because of its
prediction of tachyonic sleptons. An appealing solution to this problem was
proposed by Pomarol and Rattazzi where a threshold controlled by a light field
deflects the anomaly mediated supersymmetry breaking trajectory, thus evading
tachyonic sleptons. In this paper we examine an alternate class of deflection
models where the non-supersymmetric threshold is accompanied by a heavy,
instead of light, singlet. The low energy form of this model is the so-called
extended anomaly mediation proposed by Nelson and Weiner, but with potential
for a much higher deflection threshold. The existence of this high deflection
threshold implies that the space of anomaly mediated supersymmetry breaking
deflecting models is larger than previously thought.Comment: 14 pages, 1 figure (version to appear in JHEP
Regular monitoring and targeted removals can control lionfish in Mediterranean Marine Protected Areas
An adaptive seamless assist-as-needed control scheme for lower extremity rehabilitation robots
Most control methods deployed in lower extremity rehabilitation robots cannot automatically adjust to different gait cycle stages and different rehabilitation training modes for different impairment subjects. This article presents a continuous seamless assist-as-needed control method based on sliding mode adaptive control. A forgetting factor is introduced, and a small trajectory deviation from reference normal gait trajectory is used to learn the rehabilitation level of a human subject in real time. The assistance torque needed to complete the reference normal gait trajectory is learned through radial basis function neural networks, so that the rehabilitation robot can adaptively provide the assistance torque according to subjectās needs. The performance and efficiency of this adaptive seamless assist-as-needed control scheme are tested and validated by 12 volunteers on a rehabilitation robot prototype. The results show that the proposed control scheme could adaptively reduce the robotic assistance according to subjectās rehabilitation level, and the robotic assistance torque depends on the forgetting factor and the active participation level of subjects
Synthetic Lethality of Chk1 Inhibition Combined with p53 and/or p21 Loss During a DNA Damage Response in Normal and Tumor Cells
Cell cycle checkpoints ensure genome integrity and are frequently compromised in human cancers. A therapeutic strategy being explored takes advantage of checkpoint defects in p53-deficient tumors in order to sensitize them to DNA-damaging agents by eliminating Chk1-mediated checkpoint responses. Using mouse models, we demonstrated that p21 is a key determinant of how cells respond to the combination of DNA damage and Chk1 inhibition (combination therapy) in normal cells as well as in tumors. Loss of p21 sensitized normal cells to the combination therapy much more than did p53 loss and the enhanced lethality was partially blocked by CDK inhibition. In addition, basal pools of p21 (p53 independent) provided p53 null cells with protection from the combination therapy. Our results uncover a novel p53-independent function for p21 in protecting cells from the lethal effects of DNA damage followed by Chk1 inhibition. As p21 levels are low in a significant fraction of colorectal tumors, they are predicted to be particularly sensitive to the combination therapy. Results reported in this study support this prediction
Influence of Dopamine on Precursor Cell Proliferation and Differentiation in the Embryonic Mouse Telencephalon
Conflicting interests and growing importance of nonāindigenous species in commercial and recreational fisheries of the Mediterranean Sea
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