Head-up displays in action video games: the effects of physical and semantic characteristics on player performance and experience

International audienceThis study aimed to investigate how different characteristics of head-up displays (HUDs) can impact the performance and subjective experience of players in action video games. HUDs are a very common way to display contextual information. However, very few studies have empirically investigated the influence of HUD design on player performance and experience from a human information processing perspective. Four experiments were conducted in which players of different levels of expertise played commercial action video games. The physical characteristics of HUD, i.e. the physical appearance of the information on screen such as size and color (Experiments 1-2), and the semantic characteristics, i.e. the composition (nature and content) of the information (Experiments 3-4), were manipulated. Player performance and subjective experience were systematically assessed. The results showed that players’ performance and experience were impacted when the semantic characteristics of the HUD elements were manipulated and when their nature was relevant to the main task players have to perform within the game. The performance of more experienced players was particularly affected in this case. In contrast, the results did not show that altering physical or semantic characteristics that were less relevant to the game main task would affect players’ performance and subjective experience

A Keratin 7 and E-Cadherin Signature Is Highly Predictive of Tubo-Ovarian High-Grade Serous Carcinoma Prognosis

During tubo-ovarian high-grade serous carcinoma (HGSC) progression, tumoral cells undergo phenotypic changes in their epithelial marker profiles, which are essential for dissemination processes. Here, we set out to determine whether standard epithelial markers can predict HGSC patient prognosis. Levels of E-CADH, KRT7, KRT18, KRT19 were quantified in 18 HGSC cell lines by Western blot and in a Discovery cohort tissue microarray (TMA) (n = 101 patients) using immunofluorescence. E-CADH and KRT7 levels were subsequently analyzed in the TMA of the Canadian Ovarian Experimental Unified Resource cohort (COEUR, n = 1158 patients) and in public datasets. Epithelial marker expression was highly variable in HGSC cell lines and tissues. In the Discovery cohort, high levels of KRT7 and KRT19 were associated with an unfavorable prognosis, whereas high E-CADH expression indicated a better outcome. Expression of KRT7 and E-CADH gave a robust combination to predict overall survival (OS, p = 0.004) and progression free survival (PFS, p = 5.5 × 10−4) by Kaplan–Meier analysis. In the COEUR cohort, the E-CADH-KRT7 signature was a strong independent prognostic biomarker (OS, HR = 1.6, p = 2.9 × 10−4; PFS, HR = 1.3, p = 0.008) and predicted a poor patient response to chemotherapy (p = 1.3 × 10−4). Our results identify a combination of two epithelial markers as highly significant indicators of HGSC patient prognosis and treatment response

SI TRACEABLE HIGH PRECISION SPECTROSCOPY OF OZONE USING A QUANTUM CASCADE LASER AT 9.5 MICROMETER

International audienceFor subDoppler ozone spectroscopy, we have implemented a QCL laser stabilisation scheme based on an optical frequency comb (OFC) referenced to the international system of units (SI) via an optical fiber which links to the REFIMEVE network [6]. To compare the QCL at 31 THz to a reference laser frequency comb at 193 THz (SI traceable), a sum frequency generation (SFG) scheme between the QCL and an OFC at 162 THz in an oriented patterned GaAs crystal is implemented

SI TRACEABLE HIGH PRECISION SPECTROSCOPY OF OZONE USING A QUANTUM CASCADE LASER AT 9.5 MICROMETER

International audienceFor subDoppler ozone spectroscopy, we have implemented a QCL laser stabilisation scheme based on an optical frequency comb (OFC) referenced to the international system of units (SI) via an optical fiber which links to the REFIMEVE network [6]. To compare the QCL at 31 THz to a reference laser frequency comb at 193 THz (SI traceable), a sum frequency generation (SFG) scheme between the QCL and an OFC at 162 THz in an oriented patterned GaAs crystal is implemented

Si Traceable High Precision Spectroscopy Of Ozone Using A Quantum Cascade Laser At 9.5 Micrometer

International audienceFor subDoppler ozone spectroscopy, we have implemented a QCL laser stabilisation scheme based on an optical frequency comb (OFC) referenced to the international system of units (SI) via an optical fiber which links to the REFIMEVE network [6]. To compare the QCL at 31 THz to a reference laser frequency comb at 193 THz (SI traceable), a sum frequency generation (SFG) scheme between the QCL and an OFC at 162 THz in an oriented patterned GaAs crystal is implemented