Non-Valvuler Atriyal Fibrilasyonu Olan Hastalarda Kanama Risk Sınıflandırılmasında Platelet-Lenfosit Oranının Yeni Kullanımları: Pilot Çalışma

Objective: The primary aim of this study was to investigate the role of platelet-lymphocyte ratio (PLR) to predict bleeding risk in nonvalvular atrial fibrillation (NVAF). Secondary aim was to determine the possible relation between PLR and thromboembolic and bleeding risk scores. Tertiary aim was to evaluate the predictive value of PLR for the patients in the therapeutic international normalized ratio (INR) range. Method: PLR was calculated from the complete blood count of 228 patients who were under warfarin management for NVAF. The patients were called and it was questioned whether they had experienced the bleeding event within six months after measurement of the PLR values. Correspondence/Yazışma Adresi: Kahraman Cosansu, Deparment of Cardiology, Sakarya University, Education and Research Hospital Sakarya, Turkey, 54100 e-mail: [email protected] DOI: 10.5798/dicletip.705814 Results: Bleeding event was observed in 48 patients after the PLR was calculated. It was found significantly correlation between PLR and CHA2DVAS2C (p165,9 was determined significant indicator for bleeding (p 165,9 değeri kanama için önemli bir gösterge olarak belirlendi (p <0.001) ve 12 kattan fazla kanama riski olduğunu gösterdi (12.27, [5.74-26.21]). Sonuç: Bu çalışmanın sonuçları PLR'nin kanama riskini saptamak için yararlı bir parametre olabileceğini göstermektedir. Bildiğimiz kadarıyla, bu PLR'nin hem CHA2DS2-VASc hem de HAS-BLED risk skorları ile korelasyonunu gösteren ilk çalışmadır. PLR ayrıca terapötik INR aralığındaki hastaları da öngörebilir