Building an immune-mediated coagulopathy consensus: early recognition and evaluation to enhance post-surgical patient safety

Topical hemostats, fibrin sealants, and surgical adhesives are regularly used in a variety of surgical procedures involving multiple disciplines. Generally, these adjuncts to surgical hemostasis are valuable means for improving wound visualization, reducing blood loss or adding tissue adherence; however, some of these agents are responsible for under-recognized adverse reactions and outcomes. Bovine thrombin, for example, is a topical hemostat with a long history of clinical application that is widely used alone or in combination with other hemostatic agents. Hematologists and coagulation experts are aware that these agents can lead to development of an immune-mediated coagulopathy (IMC). A paucity of data on the incidence of IMC contributes to under-recognition and leaves many surgeons unaware that this clinical entity, originating from normal immune responses to foreign antigen exposure, requires enhanced post-operative vigilance and judicious clinical judgment to achieve best outcomes

The Dutch modals, a paradigm?

This paper addresses the question how to define the notion of a "paradigm", as a cognitively real phenomenon. The discussion is based on the case of a set of forms from a linguistic class that is not part of the traditional domain of "paradigmhood" (i.e. inflectional morphology): the modal auxiliaries in Dutch. The paper presents the results of a few studies into the diachronic evolution of these forms, grammatically and semantically, showing how a subset of them has gradually accumulated shared features and developed an internal division of labor, thus displaying active group behavior

The Dutch modals, a paradigm?

This paper addresses the question how to define the notion of a "paradigm", as a cognitively real phenomenon. The discussion is based on the case of a set of forms from a linguistic class that is not part of the traditional domain of "paradigmhood" (i.e. inflectional morphology): the modal auxiliaries in Dutch. The paper presents the results of a few studies into the diachronic evolution of these forms, grammatically and semantically, showing how a subset of them has gradually accumulated shared features and developed an internal division of labor, thus displaying active group behavior

Ion exchange chromatographic behavior of ninhydrin positive substances

The elution positions of 92 ninhydrin positive compounds on a single column amino acid analyzer using Efron's buffer gradient are presented. © 1971, Taylor & Francis Group, LLC. All rights reserved.SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Single-cell proteomics and transcriptomics capture eosinophil development and identify the role of IL-5 in their lineage transit amplification

The activities, ontogeny, and mechanisms of lineage expansion of eosinophils are less well resolved than those of other immune cells, despite the use of biological therapies targeting the eosinophilia-promoting cytokine interleukin (IL)-5 or its receptor, IL-5Rα. We combined single-cell proteomics and transcriptomics and generated transgenic IL-5Rα reporter mice to revisit eosinophilopoiesis. We reconciled human and murine eosinophilopoiesis and provided extensive cell-surface immunophenotyping and transcriptomes at different stages along the continuum of eosinophil maturation. We used these resources to show that IL-5 promoted eosinophil-lineage expansion via transit amplification, while its deletion or neutralization did not compromise eosinophil maturation. Informed from our resources, we also showed that interferon response factor-8, considered an essential promoter of myelopoiesis, was not intrinsically required for eosinophilopoiesis. This work hence provides resources, methods, and insights for understanding eosinophil ontogeny, the effects of current precision therapeutics, and the regulation of eosinophil development and numbers in health and disease.</p

Paradigms regained: Theoretical and empirical arguments for the reassessment of the notion of paradigm

The volume discusses the breadth of applications for an extended notion of paradigm. Paradigms in this sense are not only tools of morphological description but constitute the inherent structure of grammar. Grammatical paradigms are structural sets forming holistic, semiotic structures with an informational value of their own. We argue that as such, paradigms are a part of speaker knowledge and provide necessary structuring for grammaticalization processes. The papers discuss theoretical as well as conceptual questions and explore different domains of grammatical phenomena, ranging from grammaticalization, morphology, and cognitive semantics to modality, aiming to illustrate what the concept of grammatical paradigms can and cannot (yet) explain

Paradigms regained: Theoretical and empirical arguments for the reassessment of the notion of paradigm

The volume discusses the breadth of applications for an extended notion of paradigm. Paradigms in this sense are not only tools of morphological description but constitute the inherent structure of grammar. Grammatical paradigms are structural sets forming holistic, semiotic structures with an informational value of their own. We argue that as such, paradigms are a part of speaker knowledge and provide necessary structuring for grammaticalization processes. The papers discuss theoretical as well as conceptual questions and explore different domains of grammatical phenomena, ranging from grammaticalization, morphology, and cognitive semantics to modality, aiming to illustrate what the concept of grammatical paradigms can and cannot (yet) explain

Paradigms regained: Theoretical and empirical arguments for the reassessment of the notion of paradigm

The volume discusses the breadth of applications for an extended notion of paradigm. Paradigms in this sense are not only tools of morphological description but constitute the inherent structure of grammar. Grammatical paradigms are structural sets forming holistic, semiotic structures with an informational value of their own. We argue that as such, paradigms are a part of speaker knowledge and provide necessary structuring for grammaticalization processes. The papers discuss theoretical as well as conceptual questions and explore different domains of grammatical phenomena, ranging from grammaticalization, morphology, and cognitive semantics to modality, aiming to illustrate what the concept of grammatical paradigms can and cannot (yet) explain