13 research outputs found

    Induction of protective immunity against experimental infection with malaria using synthetic peptides

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    Synthetic peptides are potential vaccine candidates because they may be able to induce high antibody titres and specific cellular immune responses against native proteins and thus the whole invading organism. In a previous study we showed that immunization with molecules of relative molecular mass (Mr) 155,000 (155K) 83K, 55K and 35K, specific for the late schizont and merozoite stages of Plasmodium falciparum, could elicit either partial or total protection in Aotus trivirgatus monkeys experimentally infected with P. falciparum. Here we have chemically synthesized 18 peptides corresponding to different fragments of these proteins to immunize Aotus trivirgatus monkeys. Some peptides gave partial protection from challenge with P. falciparum parasites, but none provided complete protection individually. A combination of three partially protective peptides gave complete or almost complete protection, however, suggesting that this particular combination of peptides is a good candidate for a malaria vaccine

    Bibliometric analyses of physical and occupational therapy faculty across Canada indicate productivity and impact of rehabilitation research

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    © 2015, University of Toronto Press Inc. All rights reserved. Purpose: This study examines physical and occupational therapy faculty across Canada, using bibliometrics and federal funding as indicators of academic impact, and considers the validity of various bibliometric indices. Methods: Faculty members were identified and their rank, professional designation, and department obtained from faculty Web sites. Bibliometric indicators were determined using Publish or Perish software. An independent author (not a faculty member) inspected the data to remove any incorrectly attributed publications. The h-index, citation years, g-index, and total number of citations for each faculty member were retrieved. The Canadian Institutes of Health Research (CIHR) funding database was used to determine the amount of research funding provided to each faculty member as a principal investigator (PI) and his or her total CIHR funding received. Mean faculty indicators by university, rank, gender, and profession were determined. Analysis of variance (ANOVA) was used to detect differences by rank and gender, and measures of association (Pearson correlation coefficients and multiple regression) were used to identify factors that affected h-index and PI funding received. Results: A total of 347 physical and occupational therapy faculty were identified. The median h-index was 5 (inter-quartile range [IQR] 2–8) for assistant professors, 11 (IQR 7– 15) for associate professors, and 18 (IQR 12–26) for full professors. ANOVA indicated no significant differences between male and female faculty in terms of h-index or funding received. Regression analysis indicated that 58% of h-index variance could be explained by gender (p = 0.039), appointment within a department that provides a (rehabilitation science) PhD programme (p \u3c 0.001), rank (p \u3c 0.001), CIHR PI funding (p = 0.001), or total CIHR funding (p \u3c 0.001). Significant predictors of the amount of CIHR funding received as a PI included h-index (p \u3c 0.001) and total number of citations (p = 0.023), which together explained 27% of the variation in funding received. Conclusion: The h-index, although not without flaws, provides a useful metric that indicates that physical and occupational faculty in Canada are productive scientists having a measurable impact and that this impact increases with rank and greater funding

    The relationship between people and lizards in Patagonia

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    Abstract: Understanding how human beings perceive and interact with the local herpetofauna is fundamental for its conservation. In this chapter, we propose looking forward to the local ecological knowledge (LEK) of the Patagonian lizards, especially the "matuasto". The preliminary analysis of ethnohistorical sources points out the relevant role of "matuastos" in the cosmologies of the original people from Patagonia, often considered as immortal, selfish and harmful beings. Field reports agree on the warning not to disturb these territorial lizards, otherwise they would react aggressively with bites. The recorded stories account for frequent biting events on sheep. The local perception on "matuastos" as harmful beings would provoke an attitude of caution and rejection towards them. This work provides a first overview on the relationship of lizards and the people from Patagonia while constituting an initial step for future research.Fil: Aigo, Juana del Carmen. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto de Diversidad y Evolución Austral; ArgentinaFil: Ladio, Ana Haydee. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte. Instituto de Investigaciones en Biodiversidad y Medioambiente. Universidad Nacional del Comahue. Centro Regional Universidad Bariloche. Instituto de Investigaciones en Biodiversidad y Medioambiente; ArgentinaFil: Boretto, Jorgelina Mariela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte. Instituto de Investigaciones en Biodiversidad y Medioambiente. Universidad Nacional del Comahue. Centro Regional Universidad Bariloche. Instituto de Investigaciones en Biodiversidad y Medioambiente; ArgentinaFil: Cabezas Cartes, Facundo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte. Instituto de Investigaciones en Biodiversidad y Medioambiente. Universidad Nacional del Comahue. Centro Regional Universidad Bariloche. Instituto de Investigaciones en Biodiversidad y Medioambiente; ArgentinaFil: Ibarguengoytía, Nora. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte. Instituto de Investigaciones en Biodiversidad y Medioambiente. Universidad Nacional del Comahue. Centro Regional Universidad Bariloche. Instituto de Investigaciones en Biodiversidad y Medioambiente; Argentin

    Women and Editorial Leadership of Scientific and Academic Journals: An Explorative Study

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    The gender balance/imbalance in the governance of academic journals tied to the different scientific areas (i.e., the editorial board composition) represents a rather under investigated topic among the literature stream on diversity in top academic positions. Starting from this premise, the work aims to detect the gender (im)balance within the most prestigious international journals of Accounting. After having traced the theoretical background, the research design includes the empirical investigation focused on the Accounting journals ranked in the list proposed by the Association of Business Schools (ABS) in 2015 and included in the Italian ANVUR list (2017). Results confirm the underrepresentation of women in the editorial team and leadership positions of Accounting journals, as it happens in other fields included among the STEMs (such as Medicine or Math) or non-STEM disciplines (i.e., Management and Marketing). The work has scientific implications since it points out the limited potential of women scholars in covering governing roles and gaining worldwide visibility. Editorial board membership is in fact both a professional honour in recognition of achievements and an opportunity for professional advancement. Under an operational and political perspective, it contributes to nurturing the debate on the presence of an insidious discrimination that is often not easily recognized
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