51 research outputs found
Effect of gender difference on platelet reactivity
Background Previous studies have suggested that women do not accrue equal therapeutic benefit from antiplatelet medication as compared with men. The physiological mechanism and clinical implications behind this gender disparity have yet to be established. Methods On-treatment platelet reactivity was determined in 717 men and 234 women on dual antiplatelet therapy, undergoing elective coronary stent implantation. Platelet function testing was performed using arachidonic acid and adenosine diphosphate-induced light transmittance aggregometry (LTA) and the VerifyNow P2Y12 and Aspirin assays. Also the incidence of all-cause death, non-fatal acute myocardial infarction, stent thrombosis and ischaemic stroke was evaluated. Results Women had higher baseline platelet counts than men. Women exhibited a higher magnitude of on-aspirin platelet reactivity using LTA, but not using the VerifyNow Aspirin assay. The magnitude of on-clopidogrel platelet reactivity was significantly higher in women as compared with men with both tests used. The cut-off value to identify patients at risk as well as the incidence of clinical endpoints was similar between women and men (16/234[6.8%] vs. 62/717[8.6%], p=0.38). Conclusion Although the magnitude of platelet reactivity was higher in women, the absolute difference between genders was small and both the cut-off value to identify patients at risk and the incidence of the composite endpoint were similar between genders. Thus, it is unlikely that the difference in platelet reactivity accounts for a worse prognosis in women
Can postoperative mean transprosthetic pressure gradient predict survival after aortic valve replacement?
Cardiac autonomic function in patients with acute exacerbation of chronic obstructive pulmonary disease with and without ventricular tachycardia
A retrospective case-control study evaluating thiazide-induced hyponatraemia-related hospitalisation among older Singaporeans
Intraprocedural reduction of the veno-arterial norepinephrine gradient correlates with blood pressure response after renal denervation
Influence of non-cardiac comorbidities on outcome after percutaneous mitral valve repair: results from the German transcatheter mitral valve interventions (TRAMI) registry
From SYMPLICITY HTN-3 to the Renal Denervation Global Registry: where do we stand and where should we go?
Ethnicity and sympathetic tone: predictors of the blood-pressure response to renal denervation?
Ethnicity and sympathetic tone: predictors of the blood pressure response to renal denervation?
Platelet surface expression of SDF-1 is associated with clinical outcomes in the patients with cardiovascular disease
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