5 research outputs found
Physalis angulata L. (Solanaceae): a potential host-plant of stink bugs Edessa meditabunda F. (Hemiptera, Pentatomidae)
Anxiolytic-like effects observed in rats exposed to the elevated zero-maze following treatment with 5-HT<sub>2</sub>/5-HT<sub>3</sub>/5-HT<sub>4</sub> ligands
The present study examined the effects of administering selective 5-HT antagonists and agonists to rats tested in the elevated zero-maze (EZM) model of anxiety. The EZM paradigm has advantages over the elevated plus-maze (EPM) paradigm with respect to measuring anxiety, yet has been utilized less frequently. Three experiments were conducted each with a diazepam control (0.25, 0.5 and 0.75鈥卪g/kg). In the first experiment, we administered the 5-HT(2C) antagonist RS 102221 (0.5, 1.0, and 2.0鈥卪g/kg) and 5-HT(2C) agonist MK-212 (0.25, 0.5 and 0.75鈥卪g/kg); in the second experiment, we administered the 5-HT(3) antagonist Y-25130 (0.1, 1.0 and 3.0鈥卪g/kg) and 5-HT(3) agonist SR 57227A (0.1, 1.0 and 3.0鈥卪g/kg), and in the third experiment, we administered the 5-HT(4) antagonist RS 39604 (0.01, 0.1, 1.0鈥卪g/kg) and 5-HT(4) agonist RS 67333 (0.01, 0.1 and 0.5鈥卪g/kg). The administration of 5-HT(2/3/4) subtype antagonists all generated behavioral profiles indicative of anxiolytic-like effects in the EZM, which was apparent from examination of both traditional and ethological measures. While little effect was observed from 5-HT(2) and 5-HT(3) agonists, the 5-HT(4) agonist RS 67333 was found to produce a paradoxical anxiolytic-like effect similar to that produced by the 5-HT(4) antagonist RS 39604. We conclude by discussing the implications of these findings