Diabetic foot infections: a team-oriented review of medical and surgical management

As the domestic and international incidence of diabetes and metabolic syndrome continues to rise, health care providers need to continue improving management of the long-term complications of the disease. Emergency department visits and hospital admissions for diabetic foot infections are increasingly commonplace, and a like-minded multidisciplinary team approach is needed to optimize patient care. Early recognition of severe infections, medical stabilization, appropriate antibiotic selection, early surgical intervention, and strategic plans for delayed reconstruction are crucial components of managing diabetic foot infections. The authors review initial medical and surgical management and staged surgical reconstruction of diabetic foot infections in the inpatient setting

Three dimensional electron microscopy reveals changing axonal and myelin morphology along normal and partially injured optic nerves

Following injury to the central nervous system, axons and myelin distinct from the initial injury site undergo changes associated with compromised function. Quantifying such changes is important to understanding the pathophysiology of neurotrauma; however, most studies to date used 2 dimensional (D) electron microscopy to analyse single sections, thereby failing to capture changes along individual axons. We used serial block face scanning electron microscopy (SBF SEM) to undertake 3D reconstruction of axons and myelin, analysing optic nerves from normal uninjured female rats and following partial optic nerve transection. Measures of axon and myelin dimensions were generated by examining 2D images at 5 µm intervals along the 100 µm segments. In both normal and injured animals, changes in axonal diameter, myelin thickness, fiber diameter, G-ratio and percentage myelin decompaction were apparent along the lengths of axons to varying degrees. The range of values for axon diameter along individual reconstructed axons in 3D was similar to the range from 2D datasets, encompassing reported variation in axonal diameter attributed to retinal ganglion cell diversity. 3D electron microscopy analyses have provided the means to demonstrate substantial variability in ultrastructure along the length of individual axons and to improve understanding of the pathophysiology of neurotrauma

Domestication potential and marketing of Canarium indicum nuts in the Pacific: 1. A literature review

Canarium indicum is an indigenous tree of the lowland forests of Melanesia (Papua New Guinea, Solomon Islands, Vanuatu) and parts of Indonesia producing edible nuts, commercial timber and some minor products. For thousands of years the nuts have been culturally important and a traditional food. Since the early 1990s there have been a number of projects aimed at the wider commercialization of the species, with mixed success. This review evaluates the biophysical and socio-economic literature and suggests how the domestication and commercialization processes could be taken forwards to improve the livelihoods of rural households in Melanesia. Many of the issues facing the domestication and commercialization of C. indicum nuts as an Agroforestry Tree Product (AFTP) are similar to those that will be important for the development of other AFTPs. Thus there are lessons that can be learnt from this species which make it a model for other agroforestry tree species